ID TR112_MOUSE Reviewed; 125 AA. AC Q9DCG9; Q91YP8; Q9D1N6; DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 13-JUN-2012, entry version 71. DE RecName: Full=tRNA methyltransferase 112 homolog; DE AltName: Full=TRM112-like protein; GN Name=Trmt112; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Embryo, and Kidney; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Participates both in methylation of protein and tRNA CC species. The heterodimer with HEMK2/N6AMT1 catalyzes N5- CC methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as CC methyl donor. The heterodimer with ALKBH8 catalyzes the CC methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl CC uridine at the wobble position of the anticodon loop in target CC tRNA species (By similarity). CC -!- SUBUNIT: Interacts with ALKBH8 and HEMK2/N6AMT1 (By similarity). CC -!- SIMILARITY: Belongs to the TRM112 family. CC -!- SIMILARITY: Contains 1 TRM112 domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK002791; BAB22361.1; -; mRNA. DR EMBL; AK003292; BAB22695.1; -; mRNA. DR EMBL; BC016191; AAH16191.1; -; mRNA. DR IPI; IPI00120871; -. DR RefSeq; NP_001159842.1; NM_001166370.1. DR RefSeq; NP_080582.3; NM_026306.3. DR UniGene; Mm.318804; -. DR UniGene; Mm.371597; -. DR ProteinModelPortal; Q9DCG9; -. DR SMR; Q9DCG9; 1-124. DR STRING; Q9DCG9; -. DR PhosphoSite; Q9DCG9; -. DR PRIDE; Q9DCG9; -. DR Ensembl; ENSMUST00000088257; ENSMUSP00000085591; ENSMUSG00000038812. DR Ensembl; ENSMUST00000116551; ENSMUSP00000112250; ENSMUSG00000038812. DR GeneID; 67674; -. DR KEGG; mmu:67674; -. DR UCSC; uc008gjd.2; mouse. DR CTD; 51504; -. DR MGI; MGI:1914924; Trmt112. DR eggNOG; NOG241447; -. DR GeneTree; ENSGT00390000009268; -. DR HOGENOM; HOG000181652; -. DR HOVERGEN; HBG056590; -. DR InParanoid; Q9DCG9; -. DR OMA; RLLTHNM; -. DR OrthoDB; EOG4WQ140; -. DR NextBio; 420118; -. DR ArrayExpress; Q9DCG9; -. DR Bgee; Q9DCG9; -. DR CleanEx; MM_0610038D11RIK; -. DR Genevestigator; Q9DCG9; -. DR GermOnline; ENSMUSG00000038812; Mus musculus. DR GermOnline; ENSMUSG00000070572; Mus musculus. DR InterPro; IPR005651; UPF0434/Trm112. DR Pfam; PF03966; Trm112p; 1. PE 2: Evidence at transcript level; KW Complete proteome; Reference proteome. FT CHAIN 1 125 tRNA methyltransferase 112 homolog. FT /FTId=PRO_0000215798. FT DOMAIN 2 119 TRM112. FT CONFLICT 85 85 H -> Q (in Ref. 1; BAB22695). FT CONFLICT 122 122 Missing (in Ref. 2; AAH16191). SQ SEQUENCE 125 AA; 14141 MW; A749605B3982A6F6 CRC64; MKLLTHNLLS SHVRGVGTRG FPLRLQATEV RINPVEFNPE FVARMIPKVE WAALVQAADT LNLAEVPKEP TEGYEHDETF LRKMHHVLLE VDVLEGTLQC PESGRLFPIS RGIPNMLLND EETET //