ID Q9D8I4_MOUSE Unreviewed; 101 AA. AC Q9D8I4; DT 01-JUN-2001, integrated into UniProtKB/TrEMBL. DT 01-JUN-2001, sequence version 1. DT 10-FEB-2021, entry version 111. DE SubName: Full=Thioredoxin reductase 2, mitochondrial {ECO:0000313|Ensembl:ENSMUSP00000145730}; GN Name=Txnrd2 {ECO:0000313|Ensembl:ENSMUSP00000145730, GN ECO:0000313|MGI:MGI:1347023}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAB25403.1}; RN [1] {ECO:0000313|EMBL:BAB25403.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB25403.1}; RC TISSUE=Small intestine {ECO:0000313|EMBL:BAB25403.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAB25403.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB25403.1}; RC TISSUE=Small intestine {ECO:0000313|EMBL:BAB25403.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAB25403.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB25403.1}; RC TISSUE=Small intestine {ECO:0000313|EMBL:BAB25403.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAB25403.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB25403.1}; RC TISSUE=Small intestine {ECO:0000313|EMBL:BAB25403.1}; RA Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., RA Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., RA Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., Imotani K., RA Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., RA Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., RA Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., RA Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., RA Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., RA Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., RA Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.; RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:BAB25403.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB25403.1}; RC TISSUE=Small intestine {ECO:0000313|EMBL:BAB25403.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [6] {ECO:0000313|EMBL:BAB25403.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB25403.1}; RC TISSUE=Small intestine {ECO:0000313|EMBL:BAB25403.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [7] {ECO:0000313|EMBL:BAB25403.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB25403.1}; RC TISSUE=Small intestine {ECO:0000313|EMBL:BAB25403.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAB25403.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB25403.1}; RC TISSUE=Small intestine {ECO:0000313|EMBL:BAB25403.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [9] {ECO:0000313|Ensembl:ENSMUSP00000145730, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000145730, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [10] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [11] {ECO:0000213|PubMed:23806337} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001; RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.; RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic RT pathways."; RL Mol. Cell 50:919-930(2013). RN [12] {ECO:0000313|Ensembl:ENSMUSP00000145730} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000145730}; RG Ensembl; RL Submitted (DEC-2015) to UniProtKB. CC -!- COFACTOR: CC Name=FAD; Xref=ChEBI:CHEBI:57692; CC Evidence={ECO:0000256|ARBA:ARBA00001974}; CC -!- SIMILARITY: Belongs to the class-I pyridine nucleotide-disulfide CC oxidoreductase family. {ECO:0000256|ARBA:ARBA00007532}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC133487; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AK008004; BAB25403.1; -; mRNA. DR SMR; Q9D8I4; -. DR Antibodypedia; 230; 244 antibodies. DR Ensembl; ENSMUST00000126778; ENSMUSP00000145730; ENSMUSG00000075704. DR UCSC; uc007ynz.1; mouse. DR MGI; MGI:1347023; Txnrd2. DR GeneTree; ENSGT00940000158832; -. DR ChiTaRS; Txnrd2; mouse. DR Proteomes; UP000000589; Chromosome 16. DR Bgee; ENSMUSG00000075704; Expressed in blood and 283 other tissues. DR ExpressionAtlas; Q9D8I4; baseline and differential. DR GO; GO:0016668; F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor; IEA:InterPro. DR Gene3D; 3.50.50.60; -; 1. DR InterPro; IPR036188; FAD/NAD-bd_sf. DR InterPro; IPR023753; FAD/NAD-binding_dom. DR InterPro; IPR012999; Pyr_OxRdtase_I_AS. DR Pfam; PF07992; Pyr_redox_2; 1. DR SUPFAM; SSF51905; SSF51905; 1. DR PROSITE; PS00076; PYRIDINE_REDOX_1; 1. PE 1: Evidence at protein level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW FAD {ECO:0000256|ARBA:ARBA00022827}; KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630}; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}; KW Proteomics identification {ECO:0000213|EPD:Q9D8I4, KW ECO:0000213|MaxQB:Q9D8I4, ECO:0000213|PeptideAtlas:Q9D8I4}; KW Redox-active center {ECO:0000256|ARBA:ARBA00023284}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 16..77 FT /note="Pyr_redox_2" FT /evidence="ECO:0000259|Pfam:PF07992" SQ SEQUENCE 101 AA; 10805 MW; A345599AB2A4DFCA CRC64; MSCGQKDRPK HRQQSFDLLV IGGGSGGLAC AKEAAQLGKK VAVADYVEPS PRGTKWGLGG TCVNVGCIPK KLMHQAALLG GMIRDAHHYG WEVAQPVQHN W //