ID CUL5_MOUSE Reviewed; 779 AA. AC Q9D5V5; Q8BMQ6; Q8BV53; Q8C098; DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot. DT 19-SEP-2006, sequence version 2. DT 28-NOV-2006, entry version 39. DE Cullin-5 (CUL-5). GN Name=Cul5; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; RC TISSUE=Brain, Medulla oblongata, Ovary, Testis, and Uterus; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Olfactory epithelium; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Component of E3 ubiquitin ligase complexes, which CC mediate the ubiquitination and subsequent proteasomal degradation CC of target proteins (By similarity). CC -!- PATHWAY: Ubiquitin conjugation; third step. CC -!- SUBUNIT: Part of E3 ubiquitin ligase complexes with elongin BC CC complex (TCEB1 and TCEB2), RBX1 and a substrate adapter protein CC that can be either MUF1, SOCS1, TCEB3, VHL or WSB1 (By CC similarity). CC -!- PTM: Neddylated. Deneddylated via its interaction with the COP9 CC signalosome (CSN) complex (By similarity). CC -!- SIMILARITY: Belongs to the cullin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK014894; BAB29609.1; -; mRNA. DR EMBL; AK030306; BAC26889.1; -; mRNA. DR EMBL; AK031955; BAC27621.1; -; mRNA. DR EMBL; AK046030; BAC32575.1; -; mRNA. DR EMBL; AK080305; BAC37872.1; -; mRNA. DR EMBL; BC075710; AAH75710.1; -; mRNA. DR UniGene; Mm.218910; -. DR UniGene; Mm.390160; -. DR UniGene; Mm.394328; -. DR Ensembl; ENSMUSG00000032030; Mus musculus. DR MGI; MGI:1922967; Cul5. DR ArrayExpress; Q9D5V5; -. DR GO; GO:0005515; F:protein binding; IPI:MGI. DR InterPro; IPR001373; Cullin. DR PANTHER; PTHR11932; PTHR11932; 1. DR Pfam; PF00888; Cullin; 1. DR SMART; SM00182; CULLIN; 1. DR PROSITE; PS01256; CULLIN_1; 1. DR PROSITE; PS50069; CULLIN_2; 1. KW Ubl conjugation; Ubl conjugation pathway. FT INIT_MET 0 0 By similarity. FT CHAIN 1 779 Cullin-5. FT /FTId=PRO_0000119798. FT CROSSLNK 723 723 Glycyl lysine isopeptide (Lys-Gly) FT (interchain with G-Cter in NEDD8) (By FT similarity). FT CONFLICT 572 572 W -> C (in Ref. 1; BAC27621). SQ SEQUENCE 779 AA; 90843 MW; FCEB6E517224CA7F CRC64; ATSNLLKNKG SLQFEDKWDF MHPIVLKLLR QESVTKQQWF DLFSDVHAVC LWDDKGSSKI HQALKEDILE FIKQAQARVL SHQDDTALLK AYIVEWRKFF TQCDILPKPF CQLEVTLLGK QSSNKKSNME DSIVRKLMLD TWNESIFSNI KNRLQDSAMK LVHAERLGEA FDSQLVIGVR ESYVNLCSNP EDKLQIYRDN FEKAYLDSTE RFYRTQAPSY LQQNGVQNYM KYADAKLKEE EKRALRYLET RRECNSVEAL MECCVNALVT SFKETILAEC QGMIKRNETE KLHLMFSLMD KVPNGIEPML KDLEEHIISA GLADMVAAAE TITTDSEKYV EQLLTLFNRF SKLVKEAFQD DPRFLTARDK AYKAVVNDAT IFKLELPLKQ KGVGLKTQPE SKCPELLANY CDMLLRKTPL SKKLTSEEIE AKLKEVLLVL KYVQNKDVFM RYHKAHLTRR LILDISADSE IEENMVEWLR EVGMPADYVN KLARMFQDIK VSEDLNQAFK EMHKNNKLAL PADSVNIKIL NAGAWSRSSE KVFVSLPTEL EDLIPEVEEF YKKNHSGRKL HWHHLMSNGI ITFKNEVGQY DLEVTTFQLA VLFAWNQRPR EKISFENLKL ATELPDAELR RTLWSLVAFP KLKRQVLLYD PQVNSPKDFT EGTLFSVNQD FSLIKNAKVQ KRGKINLIGR LQLTTERMRE EENEGIVQLR ILRTQEAIIQ IMKMRKKISN AQLQTELVEI LKNMFLPQKK MIKEQMEWLI EHRYIRRDEA DINTFIYMA //