ID Q9CT28_MOUSE Unreviewed; 209 AA. AC Q9CT28; DT 01-JUN-2001, integrated into UniProtKB/TrEMBL. DT 01-JUN-2001, sequence version 1. DT 24-JUL-2013, entry version 72. DE SubName: Full=Putative uncharacterized protein; DE Flags: Fragment; GN Name=Kmt2b; Synonyms=Wbp7; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Whole body; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Whole body; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Whole body; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Whole body; RA Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., RA Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., RA Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., RA Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., RA Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., RA Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., RA Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., RA Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., RA Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., RA Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., RA Muramatsu M., Hayashizaki Y.; RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Whole body; RG The RIKEN Genome Exploration Research Group Phase II Team and the RG FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Whole body; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group RG Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Whole body; RG The FANTOM Consortium, Riken Genome Exploration Research Group and RG Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Whole body; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group RG (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = CC S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. CC -!- SIMILARITY: Contains 1 SET domain. CC -!- SIMILARITY: Contains 1 post-SET domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK011392; BAB27589.1; -; mRNA. DR IPI; IPI00881005; -. DR UniGene; Mm.168688; -. DR ProteinModelPortal; Q9CT28; -. DR STRING; 10090.ENSMUSP00000006470; -. DR MGI; MGI:109565; Kmt2b. DR HOVERGEN; HBG102562; -. DR InParanoid; Q9CT28; -. DR Genevestigator; Q9CT28; -. DR GO; GO:0035097; C:histone methyltransferase complex; ISO:MGI. DR GO; GO:0042800; F:histone methyltransferase activity (H3-K4 specific); ISO:MGI. DR GO; GO:0016458; P:gene silencing; IMP:MGI. DR GO; GO:0080182; P:histone H3-K4 trimethylation; IMP:MGI. DR GO; GO:0009994; P:oocyte differentiation; IMP:MGI. DR GO; GO:0001541; P:ovarian follicle development; IMP:MGI. DR GO; GO:0030728; P:ovulation; IMP:MGI. DR GO; GO:0051569; P:regulation of histone H3-K4 methylation; IMP:MGI. DR InterPro; IPR015722; Histone-lysine_MeTfrase. DR InterPro; IPR003616; Post-SET_dom. DR InterPro; IPR001214; SET_dom. DR PANTHER; PTHR22884:SF10; PTHR22884:SF10; 1. DR Pfam; PF00856; SET; 1. DR SMART; SM00508; PostSET; 1. DR SMART; SM00317; SET; 1. DR PROSITE; PS50868; POST_SET; 1. DR PROSITE; PS50280; SET; 1. PE 2: Evidence at transcript level; KW Methyltransferase; Nucleus; Transferase. FT NON_TER 1 1 SQ SEQUENCE 209 AA; 24102 MW; F2D084A8C0CC77F7 CRC64; HGAARAEVYL RKCTFDMFNF LASQHRVLPE GATCDEEEDE VQLRSTRRAT SLELPMAMRF RHLKKTSKEA VGVYRSAIHG RGLFCKRNID AGEMVIEYSG IVIRSVLTDK REKFYDGKGI GCYMFRMDDF DVVDATMHGN AARFINHSCE PNCFSRVIHV EGQKHIVIFA LRRILRGEEL TYDYKFPIED ASNKLPCNCG AKRCRRFFN //