ID Q9CR49_MOUSE Unreviewed; 147 AA. AC Q9CR49; DT 01-JUN-2001, integrated into UniProtKB/TrEMBL. DT 01-JUN-2001, sequence version 1. DT 23-MAY-2018, entry version 147. DE SubName: Full=Globin b1 {ECO:0000313|EMBL:SAI82195.1}; DE SubName: Full=Hemoglobin Y, beta-like embryonic chain {ECO:0000313|EMBL:AAH57014.1}; DE SubName: Full=Hemoglobin subunit epsilon-Y2 {ECO:0000313|Ensembl:ENSMUSP00000033229}; GN Name=Hbb-y {ECO:0000313|EMBL:AAH57014.1, GN ECO:0000313|Ensembl:ENSMUSP00000033229, ECO:0000313|MGI:MGI:96027}; GN Synonyms=Glnb1 {ECO:0000313|EMBL:SAI82195.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAB28541.1}; RN [1] {ECO:0000313|EMBL:BAB28541.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB28541.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAB28541.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAB28541.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB28541.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAB28541.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAB28541.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB28541.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAB28541.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAB28541.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB28541.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAB28541.1}; RA Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., RA Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., RA Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., RA Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., RA Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., RA Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., RA Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., RA Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., RA Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., RA Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., RA Muramatsu M., Hayashizaki Y.; RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:BAB28541.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB28541.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAB28541.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [6] {ECO:0000313|EMBL:BAB28541.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB28541.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAB28541.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [7] {ECO:0000313|EMBL:AAH57014.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH57014.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAH57014.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] {ECO:0000313|EMBL:BAB28541.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB28541.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAB28541.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [9] {ECO:0000313|EMBL:BAB28541.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB28541.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:BAB28541.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [10] {ECO:0000313|Ensembl:ENSMUSP00000033229, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000033229, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [11] {ECO:0000313|Ensembl:ENSMUSP00000033229} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000033229}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [12] {ECO:0000313|EMBL:SAI82195.1} RP NUCLEOTIDE SEQUENCE. RX DOI=10.1016/j.genrep.2016.10.009; RA Premzl M.; RT "Comparative genomic analysis of eutherian globin genes."; RL Gene Rep 5:163-166(2016). CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000256|PROSITE- CC ProRule:PRU00238, ECO:0000256|RuleBase:RU000356, CC ECO:0000256|SAAS:SAAS00776669}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC131116; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC057014; AAH57014.1; -; mRNA. DR EMBL; AK012501; BAB28284.1; -; mRNA. DR EMBL; AK012897; BAB28541.1; -; mRNA. DR EMBL; LT548151; SAI82195.1; -; Genomic_DNA. DR RefSeq; NP_032247.1; NM_008221.4. DR UniGene; Mm.440164; -. DR IntAct; Q9CR49; 1. DR Ensembl; ENSMUST00000033229; ENSMUSP00000033229; ENSMUSG00000052187. DR GeneID; 15135; -. DR KEGG; mmu:15135; -. DR UCSC; uc009iut.1; mouse. DR CTD; 15135; -. DR MGI; MGI:96027; Hbb-y. DR eggNOG; KOG3378; Eukaryota. DR eggNOG; COG1018; LUCA. DR GeneTree; ENSGT00760000119197; -. DR HOVERGEN; HBG009709; -. DR KO; K13825; -. DR OMA; PTAIIGN; -. DR OrthoDB; EOG091G0R7W; -. DR TreeFam; TF333268; -. DR Reactome; R-MMU-983231; Factors involved in megakaryocyte development and platelet production. DR ChiTaRS; Hbb-y; mouse. DR Proteomes; UP000000589; Chromosome 7. DR Bgee; ENSMUSG00000052187; -. DR GO; GO:0005833; C:hemoglobin complex; IEA:Ensembl. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0031721; F:hemoglobin alpha binding; IEA:Ensembl. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0019825; F:oxygen binding; IEA:InterPro. DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW. DR GO; GO:0051291; P:protein heterooligomerization; IEA:Ensembl. DR GO; GO:0014070; P:response to organic cyclic compound; IEA:Ensembl. DR CDD; cd08925; Hb-beta_like; 1. DR Gene3D; 1.10.490.10; -; 1. DR InterPro; IPR000971; Globin. DR InterPro; IPR009050; Globin-like_sf. DR InterPro; IPR012292; Globin/Proto. DR InterPro; IPR002337; Haemoglobin_b. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00814; BETAHAEM. DR SUPFAM; SSF46458; SSF46458; 1. DR PROSITE; PS01033; GLOBIN; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Heme {ECO:0000256|PROSITE-ProRule:PRU00238, KW ECO:0000256|RuleBase:RU000356, ECO:0000256|SAAS:SAAS00776668}; KW Iron {ECO:0000256|PROSITE-ProRule:PRU00238, KW ECO:0000256|SAAS:SAAS00776671}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00238, KW ECO:0000256|SAAS:SAAS00776667}; KW Oxygen transport {ECO:0000256|PROSITE-ProRule:PRU00238, KW ECO:0000256|RuleBase:RU000356, ECO:0000256|SAAS:SAAS00776666}; KW Proteomics identification {ECO:0000213|MaxQB:Q9CR49, KW ECO:0000213|PeptideAtlas:Q9CR49}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transport {ECO:0000256|PROSITE-ProRule:PRU00238, KW ECO:0000256|RuleBase:RU000356, ECO:0000256|SAAS:SAAS00776670}. FT DOMAIN 4 147 GLOBIN. {ECO:0000259|PROSITE:PS01033}. FT METAL 64 64 Iron (heme distal ligand). FT {ECO:0000256|PROSITE-ProRule:PRU00238}. FT METAL 93 93 Iron (heme proximal ligand). FT {ECO:0000256|PROSITE-ProRule:PRU00238}. SQ SEQUENCE 147 AA; 16146 MW; 21D6767F697583B4 CRC64; MVNFTAEEKT LINGLWSKVN VEEVGGEALG RLLVVYPWTH RFFDSFGNLS SASAIMGNPR VKAHGKKVLT AFGESIKNLD NLKSALAKLS ELHCDKLHVD PENFKLLGNV LVIVLASHFG NEFTAEMQAA WQKLVAGVAT ALSHKYH //