ID PMK_ARATH Reviewed; 505 AA. AC Q9C6T1; Q681V6; Q682Q9; DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 25-OCT-2017, entry version 132. DE RecName: Full=Phosphomevalonate kinase, peroxisomal {ECO:0000305}; DE EC=2.7.4.2 {ECO:0000305}; DE AltName: Full=5-phosphomevalonate kinase {ECO:0000303|PubMed:21655959}; DE Short=AtPMK {ECO:0000303|PubMed:21655959}; GN Name=PMK {ECO:0000303|PubMed:21655959}; GN OrderedLocusNames=At1g31910 {ECO:0000312|Araport:AT1G31910}; GN ORFNames=F5M6.9 {ECO:0000312|EMBL:AAG50716.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=11130712; DOI=10.1038/35048500; RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., RA White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., RA Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., RA Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., RA Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., RA Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., RA Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., RA Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., RA Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., RA Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., RA Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., RA Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., RA Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., RA Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., RA Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.; RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis RT thaliana."; RL Nature 408:816-820(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RG The Arabidopsis Information Portal (Araport); RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC STRAIN=cv. Columbia; RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K., RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., RA Hayashizaki Y., Shinozaki K.; RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."; RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP SUBCELLULAR LOCATION. RX PubMed=21655959; DOI=10.1007/s00425-011-1444-6; RA Simkin A.J., Guirimand G., Papon N., Courdavault V., Thabet I., RA Ginis O., Bouzid S., Giglioli-Guivarc'h N., Clastre M.; RT "Peroxisomal localisation of the final steps of the mevalonic acid RT pathway in planta."; RL Planta 234:903-914(2011). RN [5] RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22223895; DOI=10.1074/mcp.M111.015131; RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., RA Meinnel T., Giglione C.; RT "Comparative large-scale characterisation of plant vs. mammal proteins RT reveals similar and idiosyncratic N-alpha acetylation features."; RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012). CC -!- CATALYTIC ACTIVITY: ATP + (R)-5-phosphomevalonate = ADP + (R)-5- CC diphosphomevalonate. {ECO:0000305}. CC -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate CC biosynthesis via mevalonate pathway; isopentenyl diphosphate from CC (R)-mevalonate: step 2/3. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:21655959}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9C6T1-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9C6T1-2; Sequence=VSP_058117, VSP_058118; CC Note=No experimental confirmation available. {ECO:0000305}; CC -!- SIMILARITY: Belongs to the GHMP kinase family. Mevalonate kinase CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC079041; AAG50716.1; -; Genomic_DNA. DR EMBL; CP002684; AEE31414.1; -; Genomic_DNA. DR EMBL; CP002684; AEE31415.1; -; Genomic_DNA. DR EMBL; AK175299; BAD43062.1; -; mRNA. DR EMBL; AK175308; BAD43071.1; -; mRNA. DR EMBL; AK175511; BAD43274.1; -; mRNA. DR EMBL; AK176723; BAD44486.1; -; mRNA. DR EMBL; AK176889; BAD44652.1; -; mRNA. DR EMBL; AK221797; BAD93949.1; -; mRNA. DR PIR; C86443; C86443. DR RefSeq; NP_001185124.1; NM_001198195.1. [Q9C6T1-2] DR RefSeq; NP_174473.1; NM_102927.3. [Q9C6T1-1] DR UniGene; At.17280; -. DR ProteinModelPortal; Q9C6T1; -. DR STRING; 3702.AT1G31910.1; -. DR iPTMnet; Q9C6T1; -. DR PaxDb; Q9C6T1; -. DR EnsemblPlants; AT1G31910.1; AT1G31910.1; AT1G31910. [Q9C6T1-1] DR EnsemblPlants; AT1G31910.2; AT1G31910.2; AT1G31910. [Q9C6T1-2] DR GeneID; 840081; -. DR Gramene; AT1G31910.1; AT1G31910.1; AT1G31910. DR Gramene; AT1G31910.2; AT1G31910.2; AT1G31910. DR KEGG; ath:AT1G31910; -. DR Araport; AT1G31910; -. DR TAIR; locus:2034466; AT1G31910. DR eggNOG; KOG4519; Eukaryota. DR eggNOG; COG3890; LUCA. DR KO; K00938; -. DR OMA; RMCDVDC; -. DR OrthoDB; EOG09360943; -. DR PhylomeDB; Q9C6T1; -. DR BioCyc; ARA:AT1G31910-MONOMER; -. DR UniPathway; UPA00057; UER00099. DR PRO; PR:Q9C6T1; -. DR Proteomes; UP000006548; Chromosome 1. DR GO; GO:0005777; C:peroxisome; IDA:UniProtKB. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004631; F:phosphomevalonate kinase activity; IEA:UniProtKB-EC. DR GO; GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IEA:UniProtKB-UniPathway. DR GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. DR Gene3D; 3.30.230.10; -; 1. DR Gene3D; 3.30.70.890; -; 1. DR InterPro; IPR016005; Erg8. DR InterPro; IPR013750; GHMP_kinase_C_dom. DR InterPro; IPR036554; GHMP_kinase_C_sf. DR InterPro; IPR006204; GHMP_kinase_N_dom. DR InterPro; IPR035102; Phosphomevalonate_kinase. DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold. DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr. DR PANTHER; PTHR31814; PTHR31814; 1. DR Pfam; PF08544; GHMP_kinases_C; 1. DR Pfam; PF00288; GHMP_kinases_N; 1. DR PIRSF; PIRSF017288; PMK_GHMP_euk; 1. DR SUPFAM; SSF54211; SSF54211; 1. DR TIGRFAMs; TIGR01219; Pmev_kin_ERG8; 1. PE 1: Evidence at protein level; KW Acetylation; Alternative splicing; ATP-binding; Complete proteome; KW Kinase; Lipid biosynthesis; Lipid metabolism; Nucleotide-binding; KW Peroxisome; Reference proteome; Steroid biosynthesis; KW Steroid metabolism; Sterol biosynthesis; Sterol metabolism; KW Transferase. FT INIT_MET 1 1 Removed. {ECO:0000244|PubMed:22223895}. FT CHAIN 2 505 Phosphomevalonate kinase, peroxisomal. FT /FTId=PRO_0000435609. FT NP_BIND 177 187 ATP. {ECO:0000255}. FT MOTIF 57 65 Peroxisomal targeting signal PTS2. FT {ECO:0000305|PubMed:21655959}. FT MOD_RES 2 2 N-acetylalanine. FT {ECO:0000244|PubMed:22223895}. FT VAR_SEQ 418 450 IEPESQTQLLDSTMSAEGVLLAGVPGAGGFDAI -> NLNS FT IHDIRVPQIPHLEQIDFIIIDLEGPWNCR (in isoform FT 2). FT /FTId=VSP_058117. FT VAR_SEQ 451 505 Missing (in isoform 2). FT /FTId=VSP_058118. FT CONFLICT 44 44 E -> G (in Ref. 3; BAD43274). FT {ECO:0000305}. FT CONFLICT 54 54 K -> N (in Ref. 3; BAD43274). FT {ECO:0000305}. SQ SEQUENCE 505 AA; 54409 MW; B1CBA6CA338B3D63 CRC64; MAVVASAPGK VLMTGGYLVL EKPNAGLVLS TNARFYAIVK PINEEVKPES WAWKWTDVKL TSPQLSRESM YKLSLNHLTL QSVSASDSRN PFVEHAIQYA IAAAHLATEK DKESLHKLLL QGLDITILGS NDFYSYRNQI ESAGLPLTPE SLGTLAPFAS ITFNAAESNG ANSKPEVAKT GLGSSAAMTT AVVAALLHYL GVVDLSDPCK EGKFGCSDLD VIHMIAQTSH CLAQGKVGSG FDVSCAVYGS QRYVRFSPEV LSFAQVAVTG LPLNEVIGTI LKGKWDNKRT EFSLPPLMNL FLGEPGSGGS STPSMVGAVK KWQMSDPEKA RENWQNLSDA NLELETKLND LSKLAKDHWD VYLRVIKSCS VLTSEKWVLH ATEPINEAII KELLEAREAM LRIRILMRQM GEAASVPIEP ESQTQLLDST MSAEGVLLAG VPGAGGFDAI FAITLGDSGT KLTQAWSSHN VLALLVREDP HGVCLESGDP RTTCITSGVS SIHLE //