ID SODC_CRYGA Reviewed; 154 AA. AC Q9C0N4; DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 12-JUN-2007, entry version 30. DE Superoxide dismutase [Cu-Zn] (EC 1.15.1.1). GN Name=SOD1; OS Cryptococcus gattii (Filobasidiella gattii) (Cryptococcus OS bacillisporus). OC Eukaryota; Fungi; Basidiomycota; Hymenomycetes; Heterobasidiomycetes; OC Tremellomycetidae; Filobasidiales; mitosporic Filobasidiales; OC Cryptococcus. OX NCBI_TaxID=292817; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. RC STRAIN=NYS 155B, and wm 780-C; RX MEDLINE=21261961; PubMed=11368899; DOI=10.1016/S0378-1119(01)00408-5; RA Chaturvedi S., Hamilton A.J., Hobby P., Zhu G., Lowry C.V., RA Chaturvedi V.; RT "Molecular cloning, phylogenetic analysis and three-dimensional RT modeling of Cu,Zn superoxide dismutase (CnSOD1) from three varieties RT of Cryptococcus neoformans."; RL Gene 268:41-51(2001). CC -!- FUNCTION: Destroys radicals which are normally produced within the CC cells and which are toxic to biological systems (By similarity). CC -!- CATALYTIC ACTIVITY: 2 superoxide + 2 H(+) = O(2) + H(2)O(2). CC -!- COFACTOR: Binds 1 copper ion per subunit (By similarity). CC -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity). CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the Cu-Zn superoxide dismutase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF248049; AAK31918.1; -; mRNA. DR EMBL; AF248050; AAK31919.1; -; Genomic_DNA. DR EMBL; AF248051; AAK31920.1; -; Genomic_DNA. DR HSSP; P00441; 1OZU. DR InterPro; IPR001424; SOD_Cu_Zn. DR Gene3D; G3DSA:2.60.40.200; SOD_Cu_Zn; 1. DR PRINTS; PR00068; CUZNDISMTASE. DR ProDom; PD000469; SOD_CU_ZN; 1. DR PROSITE; PS00087; SOD_CU_ZN_1; 1. DR PROSITE; PS00332; SOD_CU_ZN_2; 1. KW Antioxidant; Copper; Metal-binding; Oxidoreductase; Zinc. FT INIT_MET 1 1 Removed (By similarity). FT CHAIN 2 154 Superoxide dismutase [Cu-Zn]. FT /FTId=PRO_0000164117. FT METAL 47 47 Copper (By similarity). FT METAL 49 49 Copper (By similarity). FT METAL 64 64 Copper (By similarity). FT METAL 64 64 Zinc (By similarity). FT METAL 72 72 Zinc (By similarity). FT METAL 81 81 Zinc (By similarity). FT METAL 84 84 Zinc (By similarity). FT METAL 121 121 Copper (By similarity). FT DISULFID 58 147 By similarity. SQ SEQUENCE 154 AA; 15637 MW; CA4C2B4BA8F43FE4 CRC64; MVKAVAVLKG DSPVTGVITF TQEKEGAPVT VSGDIKNLDA NAERGFHVHE FGDNTNGCTS AGPHFNPHGK NHGAPSDSER HVGDLGNVKT DGNGVASVNI SDKSLSLFGP YSIIGRTIVV HAGTDDFGKG GNAESLKTGN AGARAACGVI GISN //