ID TRYD_HUMAN STANDARD; PRT; 235 AA. AC Q9BZJ3; Q9H2Y6; O95824; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 15-JUN-2002 (Rel. 41, Last annotation update) DE Putative tryptase delta precursor (EC 3.4.21.-) (Mast cell mMCP-7- DE like) (HmMCP-3-like tryptase III). GN TPSD1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=99121069; PubMed=9920877; RA Pallaoro M., Fejzo M.S., Shayesteh L., Blount J.L., Caughey G.H.; RT "Characterization of genes encoding known and novel human mast cell RT tryptases on chromosome 16p13.3."; RL J. Biol. Chem. 274:3355-3362(1999). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21101554; PubMed=11174199; RA Min H.K., Kambe N., Schwartz L.B.; RT "Human mouse mast cell protease 7-like tryptase genes are RT pseudogenes."; RL J. Allergy Clin. Immunol. 107:315-321(2001). RN [3] RP SEQUENCE OF 46-235 FROM N.A. RA Wang H.W., McNeil H.P., Thomas P.S., Murphy B.N., Webster M.J., RA Hettiaratchi A., King G., Heywood G.J., Huang C., Stevens R.L., RA Hunt J.E.; RT "Molecular cloning and characterization of novel human tryptase cDNAs RT and splicing variants."; RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This seems to be the product of a pseudogene, it is CC probably not expressed. CC -!- SIMILARITY: BELONGS TO PEPTIDASE FAMILY S1. TRYPTASE SUBFAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF098327; AAD17845.1; ALT_INIT. DR EMBL; AF318074; AAK12909.1; -. DR EMBL; AF206664; AAG35694.1; -. DR HSSP; P20231; 1AAO. DR MEROPS; S01.054; -. DR InterPro; IPR001314; Chymotrypsin. DR InterPro; IPR001254; Ser_protease_Try. DR Pfam; PF00089; trypsin; 1. DR PRINTS; PR00722; CHYMOTRYPSIN. DR SMART; SM00020; Tryp_SPc; 1. DR PROSITE; PS50240; TRYPSIN_DOM; 1. DR PROSITE; PS00134; TRYPSIN_HIS; 1. DR PROSITE; PS00135; TRYPSIN_SER; 1. KW Hypothetical protein; Hydrolase; Serine protease; Signal; KW Zymogen. FT SIGNAL 1 18 POTENTIAL. FT PROPEP 19 30 ACTIVATION PEPTIDE (BY SIMILARITY). FT CHAIN 31 235 PUTATIVE TRYPTASE DELTA. FT ACT_SITE 74 74 CHARGE RELAY SYSTEM (BY SIMILARITY). FT ACT_SITE 121 121 CHARGE RELAY SYSTEM (BY SIMILARITY). FT ACT_SITE 224 224 CHARGE RELAY SYSTEM (BY SIMILARITY). FT DISULFID 59 75 BY SIMILARITY. FT DISULFID 155 230 BY SIMILARITY. FT DISULFID 188 211 BY SIMILARITY. FT CARBOHYD 132 132 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 235 AA; 25816 MW; B1FFB6C2A8006B22 CRC64; MLSLLLLALP VLASPAYVAP APGQALQQTG IVGGQEAPRS KWPWQVSLRV RGPYWMHFCG GSLIHPQWVL TAAHCVEPDI KDLAALRVQL REQHLYYQDQ LLPVSRIIVH PQFYIIQTGA DIALLELEEP VNISSHIHTV TLPPASETFP PGMPCWVTGW GDVDNNVHLP PPYPLKEVEV PVVENHLCNA EYHTGLHTGH SFQIVRDDML CAGSENHDSC QGDSGGPLVC KVNGT //