ID KRA31_HUMAN Reviewed; 98 AA. AC Q9BYR8; Q14DM4; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 02-OCT-2024, entry version 139. DE RecName: Full=Keratin-associated protein 3-1; DE AltName: Full=High sulfur keratin-associated protein 3.1; DE AltName: Full=Keratin-associated protein 3.1; GN Name=KRTAP3-1; Synonyms=KAP3.1, KRTAP3.1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Scalp; RX PubMed=11279113; DOI=10.1074/jbc.m100657200; RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B., RA Schweizer J.; RT "Characterization of a cluster of human high/ultrahigh sulfur keratin- RT associated protein genes embedded in the type I keratin gene domain on RT chromosome 17q12-21."; RL J. Biol. Chem. 276:19440-19451(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are CC embedded in an interfilamentous matrix, consisting of hair keratin- CC associated proteins (KRTAP), which are essential for the formation of a CC rigid and resistant hair shaft through their extensive disulfide bond CC cross-linking with abundant cysteine residues of hair keratins. The CC matrix proteins include the high-sulfur and high-glycine-tyrosine CC keratins. CC -!- SUBUNIT: Interacts with hair keratins. CC -!- INTERACTION: CC Q9BYR8; O43184-4: ADAM12; NbExp=5; IntAct=EBI-9996449, EBI-12006944; CC Q9BYR8; P21549: AGXT; NbExp=3; IntAct=EBI-9996449, EBI-727098; CC Q9BYR8; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-9996449, EBI-12224467; CC Q9BYR8; P18075: BMP7; NbExp=3; IntAct=EBI-9996449, EBI-1035195; CC Q9BYR8; P38936: CDKN1A; NbExp=3; IntAct=EBI-9996449, EBI-375077; CC Q9BYR8; P08218: CELA2B; NbExp=3; IntAct=EBI-9996449, EBI-11478642; CC Q9BYR8; Q8TCT0: CERK; NbExp=3; IntAct=EBI-9996449, EBI-10274247; CC Q9BYR8; P27918: CFP; NbExp=3; IntAct=EBI-9996449, EBI-9038570; CC Q9BYR8; Q9H1P6: CIMIP1; NbExp=3; IntAct=EBI-9996449, EBI-12155483; CC Q9BYR8; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-9996449, EBI-741032; CC Q9BYR8; Q02930-3: CREB5; NbExp=3; IntAct=EBI-9996449, EBI-10192698; CC Q9BYR8; Q99895: CTRC; NbExp=3; IntAct=EBI-9996449, EBI-10295404; CC Q9BYR8; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-9996449, EBI-3867333; CC Q9BYR8; Q9NQL9: DMRT3; NbExp=5; IntAct=EBI-9996449, EBI-9679045; CC Q9BYR8; Q92608: DOCK2; NbExp=3; IntAct=EBI-9996449, EBI-448771; CC Q9BYR8; Q92567-2: FAM168A; NbExp=3; IntAct=EBI-9996449, EBI-11978259; CC Q9BYR8; Q8WU58: FAM222B; NbExp=3; IntAct=EBI-9996449, EBI-2807642; CC Q9BYR8; O75593: FOXH1; NbExp=3; IntAct=EBI-9996449, EBI-1759806; CC Q9BYR8; O43559: FRS3; NbExp=3; IntAct=EBI-9996449, EBI-725515; CC Q9BYR8; P23769: GATA2; NbExp=3; IntAct=EBI-9996449, EBI-2806671; CC Q9BYR8; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-9996449, EBI-11975289; CC Q9BYR8; Q13227: GPS2; NbExp=3; IntAct=EBI-9996449, EBI-713355; CC Q9BYR8; P09211: GSTP1; NbExp=3; IntAct=EBI-9996449, EBI-353467; CC Q9BYR8; P08631-2: HCK; NbExp=3; IntAct=EBI-9996449, EBI-9834454; CC Q9BYR8; Q9UBP5: HEY2; NbExp=3; IntAct=EBI-9996449, EBI-750630; CC Q9BYR8; Q5SUL5: HLA-A; NbExp=3; IntAct=EBI-9996449, EBI-8561769; CC Q9BYR8; P17482: HOXB9; NbExp=3; IntAct=EBI-9996449, EBI-745290; CC Q9BYR8; O43593: HR; NbExp=3; IntAct=EBI-9996449, EBI-2880706; CC Q9BYR8; Q9ULV5-2: HSF4; NbExp=3; IntAct=EBI-9996449, EBI-12056251; CC Q9BYR8; Q14005-2: IL16; NbExp=3; IntAct=EBI-9996449, EBI-17178971; CC Q9BYR8; P16144-2: ITGB4; NbExp=3; IntAct=EBI-9996449, EBI-11051601; CC Q9BYR8; Q92993: KAT5; NbExp=3; IntAct=EBI-9996449, EBI-399080; CC Q9BYR8; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-9996449, EBI-10171774; CC Q9BYR8; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-9996449, EBI-11953846; CC Q9BYR8; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-9996449, EBI-10241252; CC Q9BYR8; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-9996449, EBI-11992140; CC Q9BYR8; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-9996449, EBI-3957672; CC Q9BYR8; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-9996449, EBI-10302392; CC Q9BYR8; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-9996449, EBI-739863; CC Q9BYR8; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-9996449, EBI-12111050; CC Q9BYR8; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-9996449, EBI-1043191; CC Q9BYR8; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-9996449, EBI-11958364; CC Q9BYR8; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-9996449, EBI-10245913; CC Q9BYR8; O14633: LCE2B; NbExp=3; IntAct=EBI-9996449, EBI-11478468; CC Q9BYR8; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-9996449, EBI-9394625; CC Q9BYR8; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-9996449, EBI-6658837; CC Q9BYR8; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-9996449, EBI-10246358; CC Q9BYR8; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-9996449, EBI-11955689; CC Q9BYR8; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-9996449, EBI-11742507; CC Q9BYR8; P61968: LMO4; NbExp=3; IntAct=EBI-9996449, EBI-2798728; CC Q9BYR8; Q15345: LRRC41; NbExp=3; IntAct=EBI-9996449, EBI-721408; CC Q9BYR8; O60336: MAPKBP1; NbExp=3; IntAct=EBI-9996449, EBI-947402; CC Q9BYR8; Q9NQ50: MRPL40; NbExp=3; IntAct=EBI-9996449, EBI-1053902; CC Q9BYR8; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-9996449, EBI-2858213; CC Q9BYR8; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-9996449, EBI-945833; CC Q9BYR8; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-9996449, EBI-741158; CC Q9BYR8; P32242: OTX1; NbExp=3; IntAct=EBI-9996449, EBI-740446; CC Q9BYR8; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-9996449, EBI-11022007; CC Q9BYR8; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-9996449, EBI-11956269; CC Q9BYR8; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-9996449, EBI-14084211; CC Q9BYR8; Q9C010-2: PKIB; NbExp=3; IntAct=EBI-9996449, EBI-12886396; CC Q9BYR8; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-9996449, EBI-769257; CC Q9BYR8; O15160: POLR1C; NbExp=3; IntAct=EBI-9996449, EBI-1055079; CC Q9BYR8; P17252: PRKCA; NbExp=3; IntAct=EBI-9996449, EBI-1383528; CC Q9BYR8; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-9996449, EBI-7199479; CC Q9BYR8; P15151: PVR; NbExp=3; IntAct=EBI-9996449, EBI-3919694; CC Q9BYR8; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-9996449, EBI-740343; CC Q9BYR8; Q6P9E2: RECK; NbExp=3; IntAct=EBI-9996449, EBI-10253121; CC Q9BYR8; Q96HR9-2: REEP6; NbExp=3; IntAct=EBI-9996449, EBI-14065960; CC Q9BYR8; Q7L0R7: RNF44; NbExp=3; IntAct=EBI-9996449, EBI-2845060; CC Q9BYR8; Q7Z3H4: SAMD7; NbExp=3; IntAct=EBI-9996449, EBI-12148649; CC Q9BYR8; Q7Z5V6-2: SAXO4; NbExp=3; IntAct=EBI-9996449, EBI-12000762; CC Q9BYR8; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-9996449, EBI-9090795; CC Q9BYR8; Q92922: SMARCC1; NbExp=3; IntAct=EBI-9996449, EBI-355653; CC Q9BYR8; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-9996449, EBI-11959123; CC Q9BYR8; Q96LM6: SPMIP9; NbExp=3; IntAct=EBI-9996449, EBI-743976; CC Q9BYR8; Q9BXF9: TEKT3; NbExp=3; IntAct=EBI-9996449, EBI-8644516; CC Q9BYR8; O43711: TLX3; NbExp=3; IntAct=EBI-9996449, EBI-3939165; CC Q9BYR8; Q6EMK4: VASN; NbExp=5; IntAct=EBI-9996449, EBI-10249550; CC Q9BYR8; O95231: VENTX; NbExp=3; IntAct=EBI-9996449, EBI-10191303; CC Q9BYR8; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-9996449, EBI-11957216; CC Q9BYR8; Q64LD2-2: WDR25; NbExp=3; IntAct=EBI-9996449, EBI-12032042; CC Q9BYR8; P61981: YWHAG; NbExp=3; IntAct=EBI-9996449, EBI-359832; CC Q9BYR8; A2RRC6: ZFHX2; NbExp=3; IntAct=EBI-9996449, EBI-11994144; CC Q9BYR8; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-9996449, EBI-744257; CC Q9BYR8; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-9996449, EBI-740232; CC -!- SIMILARITY: Belongs to the KRTAP type 3 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ406931; CAC27570.1; -; mRNA. DR EMBL; BC113077; AAI13078.1; -; mRNA. DR EMBL; BC113078; AAI13079.1; -; mRNA. DR CCDS; CCDS32645.1; -. DR RefSeq; NP_114164.1; NM_031958.1. DR AlphaFoldDB; Q9BYR8; -. DR BioGRID; 123807; 84. DR IntAct; Q9BYR8; 88. DR STRING; 9606.ENSP00000375430; -. DR SwissPalm; Q9BYR8; -. DR BioMuta; KRTAP3-1; -. DR DMDM; 38372629; -. DR MassIVE; Q9BYR8; -. DR PaxDb; 9606-ENSP00000375430; -. DR PeptideAtlas; Q9BYR8; -. DR ProteomicsDB; 79697; -. DR Antibodypedia; 76771; 28 antibodies from 5 providers. DR DNASU; 83896; -. DR Ensembl; ENST00000391588.3; ENSP00000375430.1; ENSG00000212901.4. DR Ensembl; ENST00000571440.2; ENSP00000459883.1; ENSG00000262068.3. DR GeneID; 83896; -. DR KEGG; hsa:83896; -. DR MANE-Select; ENST00000391588.3; ENSP00000375430.1; NM_031958.2; NP_114164.1. DR UCSC; uc002hvt.2; human. DR AGR; HGNC:16778; -. DR CTD; 83896; -. DR GeneCards; KRTAP3-1; -. DR HGNC; HGNC:16778; KRTAP3-1. DR HPA; ENSG00000212901; Tissue enriched (skin). DR neXtProt; NX_Q9BYR8; -. DR OpenTargets; ENSG00000212901; -. DR PharmGKB; PA38418; -. DR VEuPathDB; HostDB:ENSG00000212901; -. DR eggNOG; KOG4726; Eukaryota. DR GeneTree; ENSGT00390000001157; -. DR HOGENOM; CLU_2359185_0_0_1; -. DR InParanoid; Q9BYR8; -. DR OMA; TCPHDIS; -. DR OrthoDB; 4637758at2759; -. DR PhylomeDB; Q9BYR8; -. DR TreeFam; TF338042; -. DR PathwayCommons; Q9BYR8; -. DR Reactome; R-HSA-6805567; Keratinization. DR SignaLink; Q9BYR8; -. DR BioGRID-ORCS; 83896; 10 hits in 1138 CRISPR screens. DR GenomeRNAi; 83896; -. DR Pharos; Q9BYR8; Tdark. DR PRO; PR:Q9BYR8; -. DR Proteomes; UP000005640; Chromosome 17. DR RNAct; Q9BYR8; protein. DR Bgee; ENSG00000212901; Expressed in skin of abdomen and 61 other cell types or tissues. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0045095; C:keratin filament; IEA:InterPro. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR InterPro; IPR007659; Keratin_matx. DR PANTHER; PTHR23260; KERATIN ASSOCIATED PROTEIN 3-3-RELATED; 1. DR PANTHER; PTHR23260:SF3; KERATIN-ASSOCIATED PROTEIN 3-1; 1. DR Pfam; PF04579; Keratin_matx; 1. PE 1: Evidence at protein level; KW Keratin; Proteomics identification; Reference proteome; Repeat. FT CHAIN 1..98 FT /note="Keratin-associated protein 3-1" FT /id="PRO_0000185163" FT REPEAT 3..7 FT /note="1" FT REPEAT 8..12 FT /note="2" FT REPEAT 47..51 FT /note="3" FT REPEAT 55..59 FT /note="4" FT REGION 3..59 FT /note="4 X 5 AA repeats of C-C-X(3)" SQ SEQUENCE 98 AA; 10539 MW; 59934FD69880C797 CRC64; MYCCALRSCS VPTGPATTFC SFDKSCRCGV CLPSTCPHEI SLLQPICCDT CPPPCCKPDT YVPTCWLLNN CHPTPGLSGI NLTTYVQPGC ESPCEPRC //