ID   KRA94_HUMAN             Reviewed;         154 AA.
AC   Q9BYQ2; Q0VAE3;
DT   14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   24-JUL-2013, entry version 78.
DE   RecName: Full=Keratin-associated protein 9-4;
DE   AltName: Full=Keratin-associated protein 9.4;
DE   AltName: Full=Ultrahigh sulfur keratin-associated protein 9.4;
GN   Name=KRTAP9-4; Synonyms=KAP9.4, KRTAP9.4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT TYR-146.
RC   TISSUE=Scalp;
RX   PubMed=11279113; DOI=10.1074/jbc.M100657200;
RA   Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA   Schweizer J.;
RT   "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT   associated protein genes embedded in the type I keratin gene domain on
RT   chromosome 17q12-21.";
RL   J. Biol. Chem. 276:19440-19451(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TYR-146.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments
CC       are embedded in an interfilamentous matrix, consisting of hair
CC       keratin-associated proteins (KRTAP), which are essential for the
CC       formation of a rigid and resistant hair shaft through their
CC       extensive disulfide bond cross-linking with abundant cysteine
CC       residues of hair keratins. The matrix proteins include the high-
CC       sulfur and high-glycine-tyrosine keratins.
CC   -!- SUBUNIT: Interacts with hair keratins.
CC   -!- SIMILARITY: Belongs to the KRTAP type 9 family.
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DR   EMBL; AJ406948; CAC27587.1; -; mRNA.
DR   EMBL; AC006070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC121094; AAI21095.1; -; mRNA.
DR   IPI; IPI00260814; -.
DR   RefSeq; NP_149461.2; NM_033191.2.
DR   UniGene; Hs.528700; -.
DR   ProteinModelPortal; Q9BYQ2; -.
DR   STRING; 9606.ENSP00000334922; -.
DR   DMDM; 296434558; -.
DR   PaxDb; Q9BYQ2; -.
DR   Ensembl; ENST00000334109; ENSP00000334922; ENSG00000241595.
DR   Ensembl; ENST00000570861; ENSP00000461634; ENSG00000262896.
DR   Ensembl; ENST00000575341; ENSP00000461584; ENSG00000262512.
DR   GeneID; 85280; -.
DR   KEGG; hsa:85280; -.
DR   UCSC; uc002hwi.3; human.
DR   CTD; 85280; -.
DR   GeneCards; GC17P039405; -.
DR   HGNC; HGNC:18902; KRTAP9-4.
DR   neXtProt; NX_Q9BYQ2; -.
DR   PharmGKB; PA38750; -.
DR   eggNOG; NOG293592; -.
DR   HOGENOM; HOG000234030; -.
DR   HOVERGEN; HBG096080; -.
DR   InParanoid; Q9BYQ2; -.
DR   OMA; CKPCCSP; -.
DR   OrthoDB; EOG4MKNJ2; -.
DR   GenomeRNAi; 85280; -.
DR   NextBio; 75716; -.
DR   Bgee; Q9BYQ2; -.
DR   CleanEx; HS_KRTAP9-4; -.
DR   Genevestigator; Q9BYQ2; -.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR002494; Keratin-assoc.
DR   PANTHER; PTHR23262; PTHR23262; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Keratin; Polymorphism; Reference proteome; Repeat.
FT   CHAIN         1    154       Keratin-associated protein 9-4.
FT                                /FTId=PRO_0000185190.
FT   REPEAT        8     12       1.
FT   REPEAT       13     17       2.
FT   REPEAT       18     22       3.
FT   REPEAT       37     41       4.
FT   REPEAT       42     46       5.
FT   REPEAT       51     55       6.
FT   REPEAT       56     60       7.
FT   REPEAT       61     65       8.
FT   REPEAT       70     74       9.
FT   REPEAT       75     79       10.
FT   REPEAT       80     84       11.
FT   REPEAT       85     89       12.
FT   REPEAT      129    133       13.
FT   REPEAT      134    138       14.
FT   REPEAT      148    152       15.
FT   REGION        8    152       15 X 5 AA repeats of C-C-[RQVGE]-[SPTN]-
FT                                [TASPF].
FT   VARIANT     146    146       S -> Y (in dbSNP:rs62065349).
FT                                /FTId=VAR_060242.
SQ   SEQUENCE   154 AA;  16378 MW;  260D862E16165105 CRC64;
     MTHCCSPCCQ PTCCRTTCCR TTCWKPTTVT TCSSTPCCQP SCCVSSCCQP CCRPTCCQNT
     CCQPTCVTSC CQPSCCSTPC CQPTCCGSSC DQSSSCAPVY CRRTCYYPTT VCLPGCLNQS
     CGSNCCQPCC RPACCETTCF QPTCVSSCCQ PFCC
//