ID GPR81_HUMAN Reviewed; 346 AA. AC Q9BXC0; Q3Y5J3; Q6NXU5; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 12-DEC-2006, entry version 41. DE Probable G-protein coupled receptor 81 (G-protein coupled receptor DE 104). GN Name=GPR81; Synonyms=GPR104; ORFNames=FKSG80; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY. RX MEDLINE=21458557; PubMed=11574155; DOI=10.1016/S0378-1119(01)00651-5; RA Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., RA Lewis T., Evans J.F., George S.R., O'Dowd B.F.; RT "Discovery and mapping of ten novel G protein-coupled receptor RT genes."; RL Gene 275:83-91(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=22040266; PubMed=12044878; DOI=10.1016/S0014-5793(02)02775-8; RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; RT "Identification of G protein-coupled receptor genes from the human RT genome sequence."; RL FEBS Lett. 520:97-101(2002). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Wang Y.-G., Gong L.; RT "Molecular cloning of FKSG80, a novel gene encoding a putative RT chemokine receptor."; RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney; RA King M.M., Aronstam R.S., Sharma S.V.; RT "cDNA clones of human proteins involved in signal transduction RT sequenced by the Guthrie cDNA resource center (www.cdna.org)."; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLN-43 AND GLU-253. RA Rieder M.J., Johanson E.J., da Ponte S.H., Hastings N.C., Ahearn M.O., RA Bertucci C.B., Wong M.W., Yi Q., Nickerson D.A.; RT "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW- RT FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in pituitary tissue. Not detected in CC frontal, temporal and occipital lobes of the cortex, basal CC forebrain, caudate nucleus, nucleus accumbens, and hippocampus. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF411110; AAL26481.1; -; Genomic_DNA. DR EMBL; AB083631; BAB89344.1; -; Genomic_DNA. DR EMBL; AF345568; AAK29071.1; -; mRNA. DR EMBL; AB065866; BAC06084.1; -; Genomic_DNA. DR EMBL; AY507143; AAR92485.1; -; mRNA. DR EMBL; DQ157221; AAZ67915.1; -; Genomic_DNA. DR EMBL; BC066881; AAH66881.1; -; mRNA. DR EMBL; BC066882; AAH66882.1; -; mRNA. DR EMBL; BC066883; AAH66883.1; -; mRNA. DR EMBL; BC067484; AAH67484.1; -; mRNA. DR UniGene; Hs.524811; -. DR GermOnline; ENSG00000196917; Homo sapiens. DR Ensembl; ENSG00000196917; Homo sapiens. DR KEGG; hsa:27198; -. DR HGNC; HGNC:4532; GPR81. DR MIM; 606923; gene. DR LinkHub; Q9BXC0; -. DR ArrayExpress; Q9BXC0; -. DR RZPD-ProtExp; IOH28374; -. DR RZPD-ProtExp; W1197; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 346 Probable G-protein coupled receptor 81. FT /FTId=PRO_0000069586. FT TOPO_DOM 1 21 Extracellular (Potential). FT TRANSMEM 22 42 1 (Potential). FT TOPO_DOM 43 49 Cytoplasmic (Potential). FT TRANSMEM 50 70 2 (Potential). FT TOPO_DOM 71 89 Extracellular (Potential). FT TRANSMEM 90 110 3 (Potential). FT TOPO_DOM 111 130 Cytoplasmic (Potential). FT TRANSMEM 131 151 4 (Potential). FT TOPO_DOM 152 182 Extracellular (Potential). FT TRANSMEM 183 203 5 (Potential). FT TOPO_DOM 204 220 Cytoplasmic (Potential). FT TRANSMEM 221 241 6 (Potential). FT TOPO_DOM 242 261 Extracellular (Potential). FT TRANSMEM 262 281 7 (Potential). FT TOPO_DOM 282 346 Cytoplasmic (Potential). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT DISULFID 88 165 By similarity. FT VARIANT 43 43 H -> Q. FT /FTId=VAR_025151. FT VARIANT 253 253 D -> E. FT /FTId=VAR_025152. FT CONFLICT 113 113 R -> K (in Ref. 7; AAH66883). SQ SEQUENCE 346 AA; 39295 MW; E0DB114EEB3A47A5 CRC64; MYNGSCCRIE GDTISQVMPP LLIVAFVLGA LGNGVALCGF CFHMKTWKPS TVYLFNLAVA DFLLMICLPF RTDYYLRRRH WAFGDIPCRV GLFTLAMNRA GSIVFLTVVA ADRYFKVVHP HHAVNTISTR VAAGIVCTLW ALVILGTVYL LLENHLCVQE TAVSCESFIM ESANGWHDIM FQLEFFMPLG IILFCSFKIV WSLRRRQQLA RQARMKKATR FIMVVAIVFI TCYLPSVSAR LYFLWTVPSS ACDPSVHGAL HITLSFTYMN SMLDPLVYYF SSPSFPKFYN KLKICSLKPK QPGHSKTQRP EEMPISNLGR RSCISVANSF QSQSDGQWDP HIVEWH //