ID GP81_HUMAN STANDARD; PRT; 346 AA. AC Q9BXC0; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Probable G protein-coupled receptor GPR81 (FKSG80 protein). GN Name=GPR81; Synonyms=FKSG80; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A., AND TISSUE SPECIFICITY. RX MEDLINE=21458557; PubMed=11574155; DOI=10.1016/S0378-1119(01)00651-5; RA Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O., RA Lewis T., Evans J.F., George S.R., O'Dowd B.F.; RT "Discovery and mapping of ten novel G protein-coupled receptor RT genes."; RL Gene 275:83-91(2001). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=22040266; PubMed=12044878; RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.; RT "Identification of G protein-coupled receptor genes from the human RT genome sequence."; RL FEBS Lett. 520:97-101(2002). RN [3] RP SEQUENCE FROM N.A. RA Wang Y.-G., Gong L.; RT "Molecular cloning of FKSG80, a novel gene encoding a putative RT chemokine receptor."; RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. RN [4] RP SEQUENCE FROM N.A. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in pituitary tissue. Not detected in CC frontal, temporal and occipital lobes of the cortex, basal CC forebrain, caudate nucleus, nucleus accumbens, and hippocampus. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF411110; AAL26481.1; -. DR EMBL; AB083631; BAB89344.1; -. DR EMBL; AF345568; AAK29071.1; -. DR EMBL; AB065866; BAC06084.1; -. DR Genew; HGNC:4532; GPR81. DR MIM; 606923; -. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Glycoprotein; Transmembrane. FT DOMAIN 1 21 Extracellular (Potential). FT TRANSMEM 22 42 1 (Potential). FT DOMAIN 43 49 Cytoplasmic (Potential). FT TRANSMEM 50 70 2 (Potential). FT DOMAIN 71 89 Extracellular (Potential). FT TRANSMEM 90 110 3 (Potential). FT DOMAIN 111 130 Cytoplasmic (Potential). FT TRANSMEM 131 151 4 (Potential). FT DOMAIN 152 182 Extracellular (Potential). FT TRANSMEM 183 203 5 (Potential). FT DOMAIN 204 220 Cytoplasmic (Potential). FT TRANSMEM 221 241 6 (Potential). FT DOMAIN 242 261 Extracellular (Potential). FT TRANSMEM 262 281 7 (Potential). FT DOMAIN 282 346 Cytoplasmic (Potential). FT DISULFID 88 165 By similarity. FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 346 AA; 39295 MW; E0DB114EEB3A47A5 CRC64; MYNGSCCRIE GDTISQVMPP LLIVAFVLGA LGNGVALCGF CFHMKTWKPS TVYLFNLAVA DFLLMICLPF RTDYYLRRRH WAFGDIPCRV GLFTLAMNRA GSIVFLTVVA ADRYFKVVHP HHAVNTISTR VAAGIVCTLW ALVILGTVYL LLENHLCVQE TAVSCESFIM ESANGWHDIM FQLEFFMPLG IILFCSFKIV WSLRRRQQLA RQARMKKATR FIMVVAIVFI TCYLPSVSAR LYFLWTVPSS ACDPSVHGAL HITLSFTYMN SMLDPLVYYF SSPSFPKFYN KLKICSLKPK QPGHSKTQRP EEMPISNLGR RSCISVANSF QSQSDGQWDP HIVEWH //