ID   CC106_HUMAN             Reviewed;         280 AA.
AC   Q9BWC9; B3KUF9; D3K183; Q99786;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   12-AUG-2020, entry version 130.
DE   RecName: Full=Coiled-coil domain-containing protein 106;
GN   Name=CCDC106;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION
RP   WITH TP53.
RX   PubMed=20159018; DOI=10.1016/j.febslet.2010.02.031;
RA   Zhou J., Qiao X., Xiao L., Sun W., Wang L., Li H., Wu Y., Ding X., Hu X.,
RA   Zhou C., Zhang J.;
RT   "Identification and characterization of the novel protein CCDC106 that
RT   interacts with p53 and promotes its degradation.";
RL   FEBS Lett. 584:1085-1090(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=9110174; DOI=10.1101/gr.7.4.353;
RA   Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W.,
RA   Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.;
RT   "Large-scale concatenation cDNA sequencing.";
RL   Genome Res. 7:353-358(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-153.
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: Promotes the degradation of p53/TP53 protein and inhibits its
CC       transactivity. {ECO:0000269|PubMed:20159018}.
CC   -!- SUBUNIT: Interacts with p53/TP53. {ECO:0000269|PubMed:20159018}.
CC   -!- INTERACTION:
CC       Q9BWC9; P18848: ATF4; NbExp=14; IntAct=EBI-711501, EBI-492498;
CC       Q9BWC9; Q13698: CACNA1S; NbExp=3; IntAct=EBI-711501, EBI-5329490;
CC       Q9BWC9; Q96LK0: CEP19; NbExp=3; IntAct=EBI-711501, EBI-741885;
CC       Q9BWC9; Q8N9N8: EIF1AD; NbExp=3; IntAct=EBI-711501, EBI-750700;
CC       Q9BWC9; Q8IZU0: FAM9B; NbExp=8; IntAct=EBI-711501, EBI-10175124;
CC       Q9BWC9; Q8WVZ9: KBTBD7; NbExp=3; IntAct=EBI-711501, EBI-473695;
CC       Q9BWC9; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-711501, EBI-739909;
CC       Q9BWC9; P43364: MAGEA11; NbExp=3; IntAct=EBI-711501, EBI-739552;
CC       Q9BWC9; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-711501, EBI-746778;
CC       Q9BWC9; P41227: NAA10; NbExp=3; IntAct=EBI-711501, EBI-747693;
CC       Q9BWC9; Q6ZUT1: NKAPD1; NbExp=5; IntAct=EBI-711501, EBI-3920396;
CC       Q9BWC9; P61970: NUTF2; NbExp=3; IntAct=EBI-711501, EBI-591778;
CC       Q9BWC9; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-711501, EBI-1567797;
CC       Q9BWC9; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-711501, EBI-1504830;
CC       Q9BWC9; O00560: SDCBP; NbExp=3; IntAct=EBI-711501, EBI-727004;
CC       Q9BWC9; P04637: TP53; NbExp=3; IntAct=EBI-711501, EBI-366083;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20159018}.
CC       Note=Colocalizes with p53/TP53.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB50227.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; GU354321; ADC34060.1; -; mRNA.
DR   EMBL; GU354322; ADC34061.1; -; mRNA.
DR   EMBL; GU354323; ADC34062.1; -; mRNA.
DR   EMBL; U79303; AAB50227.1; ALT_SEQ; mRNA.
DR   EMBL; AK097095; BAG53421.1; -; mRNA.
DR   EMBL; BC000412; AAH00412.1; -; mRNA.
DR   EMBL; BC008956; AAH08956.1; -; mRNA.
DR   EMBL; CR450308; CAG29304.1; -; mRNA.
DR   CCDS; CCDS33118.1; -.
DR   RefSeq; NP_037433.2; NM_013301.2.
DR   RefSeq; XP_005258884.1; XM_005258827.2.
DR   RefSeq; XP_005258885.1; XM_005258828.2.
DR   SMR; Q9BWC9; -.
DR   BioGRID; 118952; 21.
DR   IntAct; Q9BWC9; 34.
DR   MINT; Q9BWC9; -.
DR   STRING; 9606.ENSP00000465757; -.
DR   iPTMnet; Q9BWC9; -.
DR   PhosphoSitePlus; Q9BWC9; -.
DR   BioMuta; CCDC106; -.
DR   DMDM; 74733424; -.
DR   MassIVE; Q9BWC9; -.
DR   MaxQB; Q9BWC9; -.
DR   PaxDb; Q9BWC9; -.
DR   PeptideAtlas; Q9BWC9; -.
DR   PRIDE; Q9BWC9; -.
DR   ProteomicsDB; 79267; -.
DR   Antibodypedia; 33135; 189 antibodies.
DR   DNASU; 29903; -.
DR   Ensembl; ENST00000308964; ENSP00000309681; ENSG00000173581.
DR   Ensembl; ENST00000586790; ENSP00000465757; ENSG00000173581.
DR   Ensembl; ENST00000588740; ENSP00000468539; ENSG00000173581.
DR   Ensembl; ENST00000591578; ENSP00000466870; ENSG00000173581.
DR   GeneID; 29903; -.
DR   KEGG; hsa:29903; -.
DR   UCSC; uc002qlr.4; human.
DR   CTD; 29903; -.
DR   DisGeNET; 29903; -.
DR   EuPathDB; HostDB:ENSG00000173581.7; -.
DR   GeneCards; CCDC106; -.
DR   HGNC; HGNC:30181; CCDC106.
DR   HPA; ENSG00000173581; Low tissue specificity.
DR   MIM; 613478; gene.
DR   neXtProt; NX_Q9BWC9; -.
DR   OpenTargets; ENSG00000173581; -.
DR   PharmGKB; PA145008652; -.
DR   eggNOG; ENOG502RTFM; Eukaryota.
DR   GeneTree; ENSGT00390000013183; -.
DR   InParanoid; Q9BWC9; -.
DR   OMA; MVPSKNH; -.
DR   OrthoDB; 827808at2759; -.
DR   PhylomeDB; Q9BWC9; -.
DR   TreeFam; TF331729; -.
DR   PathwayCommons; Q9BWC9; -.
DR   BioGRID-ORCS; 29903; 39 hits in 872 CRISPR screens.
DR   ChiTaRS; CCDC106; human.
DR   GenomeRNAi; 29903; -.
DR   Pharos; Q9BWC9; Tdark.
DR   PRO; PR:Q9BWC9; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q9BWC9; protein.
DR   Bgee; ENSG00000173581; Expressed in nucleus accumbens and 179 other tissues.
DR   ExpressionAtlas; Q9BWC9; baseline and differential.
DR   Genevisible; Q9BWC9; HS.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   InterPro; IPR031591; CCDC106.
DR   PANTHER; PTHR16477; PTHR16477; 1.
DR   Pfam; PF15794; CCDC106; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..280
FT                   /note="Coiled-coil domain-containing protein 106"
FT                   /id="PRO_0000274343"
FT   COILED          63..101
FT                   /evidence="ECO:0000255"
FT   MOTIF           151..164
FT                   /note="Bipartite nuclear localization signal"
FT   MOD_RES         130
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
SQ   SEQUENCE   280 AA;  32032 MW;  8A380144441AEA33 CRC64;
     MNDRSSRRRT MKDDETFEIS IPFDEAPHLD PQIFYSLSPS RRNFEEPPEA ASSALALMNS
     VKTQLHMALE RNSWLQKRIE DLEEERDFLR CQLDKFISSA RMEAEDHCRM KPGPRRMEGD
     SRGGAGGEAS DPESAASSLS GASEEGSASE RRRQKQKGGA SRRRFGKPKA RERQRVKDAD
     GVLCRYKKIL GTFQKLKSMS RAFEHHRVDR NTVALTTPIA ELLIVAPEKL AEVGEFDPSK
     ERLLEYSRRC FLALDDETLK KVQALKKSKL LLPITYRFKR
//