ID CI016_HUMAN Reviewed; 83 AA. AC Q9BUW7; Q5SYV8; Q9Y3F7; DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 22-APR-2020, entry version 137. DE RecName: Full=UPF0184 protein C9orf16; GN Name=C9orf16; ORFNames=EST00098; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Thymus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., RA Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Muscle; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-83. RX PubMed=10369878; DOI=10.1093/hmg/8.7.1313; RA Gilley J., Fried M.; RT "Extensive gene order differences within regions of conserved synteny RT between the Fugu and human genomes: implications for chromosomal evolution RT and the cloning of disease genes."; RL Hum. Mol. Genet. 8:1313-1320(1999). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=16964243; DOI=10.1038/nbt1240; RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; RT "A probability-based approach for high-throughput protein phosphorylation RT analysis and site localization."; RL Nat. Biotechnol. 24:1285-1292(2006). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a RT refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [11] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). CC -!- INTERACTION: CC Q9BUW7; Q6PJ05: ATP6V1D; NbExp=5; IntAct=EBI-752084, EBI-10253919; CC Q9BUW7; Q9Y5K8: ATP6V1D; NbExp=5; IntAct=EBI-752084, EBI-2684998; CC Q9BUW7; Q96A05: ATP6V1E2; NbExp=3; IntAct=EBI-752084, EBI-8650380; CC Q9BUW7; O15078-2: CEP290; NbExp=6; IntAct=EBI-752084, EBI-10182072; CC Q9BUW7; Q49A55: FGD4; NbExp=3; IntAct=EBI-752084, EBI-12186431; CC Q9BUW7; Q70UQ0: IKBIP; NbExp=3; IntAct=EBI-752084, EBI-2557212; CC Q9BUW7; P35900: KRT20; NbExp=9; IntAct=EBI-752084, EBI-742094; CC -!- SIMILARITY: Belongs to the UPF0184 (EST00098) family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK315753; BAG38107.1; -; mRNA. DR EMBL; AL590708; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471090; EAW87751.1; -; Genomic_DNA. DR EMBL; BC001857; AAH01857.1; -; mRNA. DR EMBL; BC008887; AAH08887.1; -; mRNA. DR EMBL; Y17450; CAB44344.1; -; Genomic_DNA. DR CCDS; CCDS6893.1; -. DR RefSeq; NP_077017.1; NM_024112.3. DR BioGrid; 122542; 16. DR DIP; DIP-29481N; -. DR IntAct; Q9BUW7; 17. DR STRING; 9606.ENSP00000362085; -. DR iPTMnet; Q9BUW7; -. DR PhosphoSitePlus; Q9BUW7; -. DR BioMuta; C9orf16; -. DR DMDM; 20137930; -. DR EPD; Q9BUW7; -. DR jPOST; Q9BUW7; -. DR MassIVE; Q9BUW7; -. DR MaxQB; Q9BUW7; -. DR PaxDb; Q9BUW7; -. DR PeptideAtlas; Q9BUW7; -. DR PRIDE; Q9BUW7; -. DR ProteomicsDB; 79140; -. DR Antibodypedia; 17364; 76 antibodies. DR Ensembl; ENST00000372994; ENSP00000362085; ENSG00000171159. DR GeneID; 79095; -. DR KEGG; hsa:79095; -. DR UCSC; uc004btp.1; human. DR CTD; 79095; -. DR GeneCards; C9orf16; -. DR HGNC; HGNC:17823; C9orf16. DR HPA; ENSG00000171159; Tissue enhanced (brain). DR neXtProt; NX_Q9BUW7; -. DR OpenTargets; ENSG00000171159; -. DR PharmGKB; PA25973; -. DR eggNOG; ENOG410J0R0; Eukaryota. DR eggNOG; ENOG410XU8R; LUCA. DR GeneTree; ENSGT00390000001761; -. DR HOGENOM; CLU_167244_0_0_1; -. DR InParanoid; Q9BUW7; -. DR OMA; EKNDRLH; -. DR OrthoDB; 1545221at2759; -. DR PhylomeDB; Q9BUW7; -. DR TreeFam; TF324640; -. DR GenomeRNAi; 79095; -. DR Pharos; Q9BUW7; Tdark. DR PRO; PR:Q9BUW7; -. DR Proteomes; UP000005640; Chromosome 9. DR RNAct; Q9BUW7; protein. DR Bgee; ENSG00000171159; Expressed in Ammon's horn and 225 other tissues. DR Genevisible; Q9BUW7; HS. DR InterPro; IPR005374; UPF0184_eukaryota. DR PANTHER; PTHR34344; PTHR34344; 1. PE 1: Evidence at protein level; KW Coiled coil; Phosphoprotein; Reference proteome. FT CHAIN 1..83 FT /note="UPF0184 protein C9orf16" FT /id="PRO_0000195161" FT COILED 25..74 FT /evidence="ECO:0000255" FT MOD_RES 82 FT /note="Phosphoserine" FT /evidence="ECO:0000244|PubMed:16964243, FT ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:19690332, FT ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:21406692" FT CONFLICT 35 FT /note="L -> V (in Ref. 5; CAB44344)" FT /evidence="ECO:0000305" SQ SEQUENCE 83 AA; 9054 MW; EBE1D0AFAAD6DABB CRC64; MSGPNGDLGM PVEAGAEGEE DGFGEAEYAA INSMLDQINS CLDHLEEKND HLHARLQELL ESNRQTRLEF QQQLGEAPSD ASP //