ID   CENPO_HUMAN             Reviewed;         300 AA.
AC   Q9BU64; B2RDC0; D6W536; Q53T55; Q96JV3;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   05-FEB-2025, entry version 169.
DE   RecName: Full=Centromere protein O;
DE            Short=CENP-O;
DE   AltName: Full=Interphase centromere complex protein 36;
GN   Name=CENPO; Synonyms=ICEN36, MCM21R;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   ARG-34.
RC   TISSUE=Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=16932742; DOI=10.1038/sj.emboj.7601293;
RA   McAinsh A.D., Meraldi P., Draviam V.M., Toso A., Sorger P.K.;
RT   "The human kinetochore proteins Nnf1R and Mcm21R are required for accurate
RT   chromosome segregation.";
RL   EMBO J. 25:4033-4049(2006).
RN   [6]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=16716197; DOI=10.1111/j.1365-2443.2006.00969.x;
RA   Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y.,
RA   Goshima N., Nomura F., Nomura N., Yoda K.;
RT   "Comprehensive analysis of the ICEN (Interphase Centromere Complex)
RT   components enriched in the CENP-A chromatin of human cells.";
RL   Genes Cells 11:673-684(2006).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH
RP   CENPH; CENPI; CENPK; CENPN; CENPP; CENPQ; CENPR AND CENPU, FUNCTION, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=16622420; DOI=10.1038/ncb1396;
RA   Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III,
RA   Desai A., Fukagawa T.;
RT   "The CENP-H-I complex is required for the efficient incorporation of newly
RT   synthesized CENP-A into centromeres.";
RL   Nat. Cell Biol. 8:446-457(2006).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE CENPA-CAD
RP   COMPLEX WITH CENPI; CENPK; CENPL; CENPP; CENPQ; CENPR AND CENPS.
RX   PubMed=16622419; DOI=10.1038/ncb1397;
RA   Foltz D.R., Jansen L.E.T., Black B.E., Bailey A.O., Yates J.R. III,
RA   Cleveland D.W.;
RT   "The human CENP-A centromeric nucleosome-associated complex.";
RL   Nat. Cell Biol. 8:458-469(2006).
RN   [9]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=18007590; DOI=10.1038/sj.emboj.7601927;
RA   McClelland S.E., Borusu S., Amaro A.C., Winter J.R., Belwal M.,
RA   McAinsh A.D., Meraldi P.;
RT   "The CENP-A NAC/CAD kinetochore complex controls chromosome congression and
RT   spindle bipolarity.";
RL   EMBO J. 26:5033-5047(2007).
RN   [10]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a
CC       complex recruited to centromeres which is involved in assembly of
CC       kinetochore proteins, mitotic progression and chromosome segregation.
CC       May be involved in incorporation of newly synthesized CENPA into
CC       centromeres via its interaction with the CENPA-NAC complex. Modulates
CC       the kinetochore-bound levels of NDC80 complex.
CC       {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197,
CC       ECO:0000269|PubMed:16932742, ECO:0000269|PubMed:18007590}.
CC   -!- SUBUNIT: Component of the CENPA-CAD complex, composed of CENPI, CENPK,
CC       CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex
CC       interacts with the CENPA-NAC complex, at least composed of CENPA,
CC       CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.
CC       {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16622420}.
CC   -!- INTERACTION:
CC       Q9BU64; Q6IPU0: CENPP; NbExp=13; IntAct=EBI-745954, EBI-10250303;
CC       Q9BU64; Q96L14: CEP170P1; NbExp=5; IntAct=EBI-745954, EBI-743488;
CC       Q9BU64; Q9UHG0: DCDC2; NbExp=3; IntAct=EBI-745954, EBI-10303987;
CC       Q9BU64; Q6FG41: FOS; NbExp=3; IntAct=EBI-745954, EBI-10198738;
CC       Q9BU64; P53539: FOSB; NbExp=3; IntAct=EBI-745954, EBI-2806743;
CC       Q9BU64; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-745954, EBI-10172876;
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere. Chromosome,
CC       centromere, kinetochore. Note=The CENPA-CAD complex is probably
CC       recruited on centromeres by the CENPA-NAC complex.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9BU64-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BU64-2; Sequence=VSP_020446;
CC   -!- SIMILARITY: Belongs to the CENP-O/MCM21 family. {ECO:0000305}.
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DR   EMBL; AK027859; BAB55414.1; -; mRNA.
DR   EMBL; AK315483; BAG37867.1; -; mRNA.
DR   EMBL; AC012073; AAY14786.1; -; Genomic_DNA.
DR   EMBL; AC013459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471053; EAX00742.1; -; Genomic_DNA.
DR   EMBL; CH471053; EAX00743.1; -; Genomic_DNA.
DR   EMBL; BC002870; AAH02870.1; -; mRNA.
DR   CCDS; CCDS1714.1; -. [Q9BU64-1]
DR   CCDS; CCDS56113.1; -. [Q9BU64-2]
DR   RefSeq; NP_001186732.1; NM_001199803.2. [Q9BU64-2]
DR   RefSeq; NP_001309030.1; NM_001322101.1. [Q9BU64-1]
DR   RefSeq; NP_077298.1; NM_024322.3. [Q9BU64-1]
DR   PDB; 7PB8; X-ray; 3.68 A; O=1-300.
DR   PDB; 7PKN; EM; 3.20 A; O=1-300.
DR   PDB; 7QOO; EM; 4.60 A; O=1-300.
DR   PDB; 7R5S; EM; 2.83 A; O=1-300.
DR   PDB; 7R5V; EM; 4.55 A; O=1-300.
DR   PDB; 7XHN; EM; 3.71 A; O/o=1-300.
DR   PDB; 7XHO; EM; 3.29 A; O=1-300.
DR   PDB; 7YWX; EM; 12.00 A; O=1-300.
DR   PDB; 7YYH; EM; 8.90 A; O=1-300.
DR   PDBsum; 7PB8; -.
DR   PDBsum; 7PKN; -.
DR   PDBsum; 7QOO; -.
DR   PDBsum; 7R5S; -.
DR   PDBsum; 7R5V; -.
DR   PDBsum; 7XHN; -.
DR   PDBsum; 7XHO; -.
DR   PDBsum; 7YWX; -.
DR   PDBsum; 7YYH; -.
DR   AlphaFoldDB; Q9BU64; -.
DR   EMDB; EMD-13473; -.
DR   EMDB; EMD-14098; -.
DR   EMDB; EMD-14336; -.
DR   EMDB; EMD-14341; -.
DR   EMDB; EMD-14351; -.
DR   EMDB; EMD-14375; -.
DR   EMDB; EMD-33196; -.
DR   EMDB; EMD-33197; -.
DR   SMR; Q9BU64; -.
DR   BioGRID; 122589; 49.
DR   ComplexPortal; CPX-5646; Kinetochore CCAN complex.
DR   CORUM; Q9BU64; -.
DR   IntAct; Q9BU64; 41.
DR   MINT; Q9BU64; -.
DR   STRING; 9606.ENSP00000370214; -.
DR   iPTMnet; Q9BU64; -.
DR   PhosphoSitePlus; Q9BU64; -.
DR   BioMuta; CENPO; -.
DR   DMDM; 74733185; -.
DR   jPOST; Q9BU64; -.
DR   MassIVE; Q9BU64; -.
DR   PaxDb; 9606-ENSP00000370214; -.
DR   PeptideAtlas; Q9BU64; -.
DR   ProteomicsDB; 79055; -. [Q9BU64-1]
DR   ProteomicsDB; 79056; -. [Q9BU64-2]
DR   Pumba; Q9BU64; -.
DR   Antibodypedia; 27556; 207 antibodies from 30 providers.
DR   DNASU; 79172; -.
DR   Ensembl; ENST00000260662.2; ENSP00000260662.1; ENSG00000138092.11. [Q9BU64-1]
DR   Ensembl; ENST00000380834.7; ENSP00000370214.2; ENSG00000138092.11. [Q9BU64-1]
DR   Ensembl; ENST00000473706.5; ENSP00000417787.1; ENSG00000138092.11. [Q9BU64-2]
DR   GeneID; 79172; -.
DR   KEGG; hsa:79172; -.
DR   MANE-Select; ENST00000380834.7; ENSP00000370214.2; NM_001322101.2; NP_001309030.1.
DR   UCSC; uc002rfp.3; human. [Q9BU64-1]
DR   AGR; HGNC:28152; -.
DR   CTD; 79172; -.
DR   DisGeNET; 79172; -.
DR   GeneCards; CENPO; -.
DR   HGNC; HGNC:28152; CENPO.
DR   HPA; ENSG00000138092; Low tissue specificity.
DR   MIM; 611504; gene.
DR   neXtProt; NX_Q9BU64; -.
DR   OpenTargets; ENSG00000138092; -.
DR   PharmGKB; PA145149197; -.
DR   VEuPathDB; HostDB:ENSG00000138092; -.
DR   eggNOG; ENOG502RY72; Eukaryota.
DR   GeneTree; ENSGT00390000016702; -.
DR   HOGENOM; CLU_079531_0_0_1; -.
DR   InParanoid; Q9BU64; -.
DR   OMA; MEWANDG; -.
DR   OrthoDB; 10050372at2759; -.
DR   PhylomeDB; Q9BU64; -.
DR   TreeFam; TF335524; -.
DR   PathwayCommons; Q9BU64; -.
DR   Reactome; R-HSA-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-HSA-2467813; Separation of Sister Chromatids.
DR   Reactome; R-HSA-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-HSA-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-HSA-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR   Reactome; R-HSA-68877; Mitotic Prometaphase.
DR   Reactome; R-HSA-9648025; EML4 and NUDC in mitotic spindle formation.
DR   SignaLink; Q9BU64; -.
DR   SIGNOR; Q9BU64; -.
DR   BioGRID-ORCS; 79172; 121 hits in 1162 CRISPR screens.
DR   ChiTaRS; CENPO; human.
DR   GeneWiki; CENPO; -.
DR   GenomeRNAi; 79172; -.
DR   Pharos; Q9BU64; Tbio.
DR   PRO; PR:Q9BU64; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q9BU64; protein.
DR   Bgee; ENSG00000138092; Expressed in ventricular zone and 122 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0000939; C:inner kinetochore; IPI:ComplexPortal.
DR   GO; GO:0031511; C:Mis6-Sim4 complex; IBA:GO_Central.
DR   GO; GO:0016604; C:nuclear body; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; NAS:ComplexPortal.
DR   GO; GO:0034508; P:centromere complex assembly; IEA:InterPro.
DR   GO; GO:0007059; P:chromosome segregation; NAS:ComplexPortal.
DR   InterPro; IPR018464; CENP-O.
DR   PANTHER; PTHR14582:SF1; CENTROMERE PROTEIN O; 1.
DR   PANTHER; PTHR14582; INNER KINETOCHORE SUBUNIT MAL2; 1.
DR   Pfam; PF09496; CENP-O; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Nucleus; Phosphoprotein; Proteomics identification;
KW   Reference proteome.
FT   CHAIN           1..300
FT                   /note="Centromere protein O"
FT                   /id="PRO_0000249502"
FT   COILED          18..42
FT                   /evidence="ECO:0000255"
FT   COILED          83..109
FT                   /evidence="ECO:0000255"
FT   MOD_RES         35
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VAR_SEQ         1..15
FT                   /note="MEQANPLRPDGESKG -> MAGILASGL (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_020446"
FT   VARIANT         34
FT                   /note="Q -> R (in dbSNP:rs1550116)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_027420"
FT   CONFLICT        235
FT                   /note="A -> V (in Ref. 1; BAB55414)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        269
FT                   /note="A -> V (in Ref. 1; BAB55414)"
FT                   /evidence="ECO:0000305"
FT   HELIX           17..26
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   HELIX           90..108
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   HELIX           109..111
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   STRAND          112..117
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   STRAND          119..130
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   STRAND          133..143
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   STRAND          145..147
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   STRAND          149..153
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   STRAND          157..159
FT                   /evidence="ECO:0007829|PDB:7XHO"
FT   HELIX           161..168
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   STRAND          169..171
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   HELIX           173..199
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   STRAND          203..205
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   HELIX           213..215
FT                   /evidence="ECO:0007829|PDB:7XHO"
FT   STRAND          217..224
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   STRAND          226..228
FT                   /evidence="ECO:0007829|PDB:7XHO"
FT   STRAND          231..238
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   STRAND          248..253
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   HELIX           262..277
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   HELIX           280..287
FT                   /evidence="ECO:0007829|PDB:7R5S"
FT   HELIX           292..294
FT                   /evidence="ECO:0007829|PDB:7XHO"
SQ   SEQUENCE   300 AA;  33786 MW;  05A89E12C6847D81 CRC64;
     MEQANPLRPD GESKGGVLAH LERLETQVSR SRKQSEELQS VQAQEGALGT KIHKLRRLRD
     ELRAVVRHRR ASVKACIANV EPNQTVEINE QEALEEKLEN VKAILQAYHF TGLSGKLTSR
     GVCVCISTAF EGNLLDSYFV DLVIQKPLRI HHHSVPVFIP LEEIAAKYLQ TNIQHFLFSL
     CEYLNAYSGR KYQADRLQSD FAALLTGPLQ RNPLCNLLSF TYKLDPGGQS FPFCARLLYK
     DLTATLPTDV TVTCQGVEVL STSWEEQRAS HETLFCTKPL HQVFASFTRK GEKLDMSLVS
//