ID WDR83_HUMAN Reviewed; 315 AA. AC Q9BRX9; B2RAF1; Q53FT6; DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 03-AUG-2022, entry version 167. DE RecName: Full=WD repeat domain-containing protein 83; DE AltName: Full=Mitogen-activated protein kinase organizer 1; DE Short=MAPK organizer 1; GN Name=WDR83; Synonyms=MORG1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney proximal tubule; RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., RA Tanaka A., Yokoyama S.; RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Muscle; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE SPLICEOSOMAL RP C COMPLEX. RX PubMed=11991638; DOI=10.1017/s1355838202021088; RA Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.; RT "Purification and characterization of native spliceosomes suitable for RT three-dimensional structural analysis."; RL RNA 8:426-439(2002). CC -!- FUNCTION: Molecular scaffold protein for various multimeric protein CC complexes. Acts as a module in the assembly of a multicomponent CC scaffold for the ERK pathway, linking ERK responses to specific CC agonists. At low concentrations it enhances ERK activation, whereas CC high concentrations lead to the inhibition of ERK activation. Also CC involved in response to hypoxia by acting as a negative regulator of CC HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote CC degradation of HIF1A. May act by recruiting signaling complexes to a CC specific upstream activator (By similarity). May also be involved in CC pre-mRNA splicing. {ECO:0000250}. CC -!- SUBUNIT: Interacts with EGLN3/PHD3. Interacts with ERK signaling CC proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and CC MAPK3/ERK1 (By similarity). Identified in the spliceosome C complex. CC {ECO:0000250, ECO:0000269|PubMed:11991638}. CC -!- INTERACTION: CC Q9BRX9; P54253: ATXN1; NbExp=6; IntAct=EBI-7705033, EBI-930964; CC Q9BRX9; P41182: BCL6; NbExp=3; IntAct=EBI-7705033, EBI-765407; CC Q9BRX9; Q96A83-2: COL26A1; NbExp=3; IntAct=EBI-7705033, EBI-21553822; CC Q9BRX9; P46108: CRK; NbExp=2; IntAct=EBI-7705033, EBI-886; CC Q9BRX9; G5E9A7: DMWD; NbExp=3; IntAct=EBI-7705033, EBI-10976677; CC Q9BRX9; O75190-2: DNAJB6; NbExp=3; IntAct=EBI-7705033, EBI-12593112; CC Q9BRX9; O14645: DNALI1; NbExp=3; IntAct=EBI-7705033, EBI-395638; CC Q9BRX9; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-7705033, EBI-11986315; CC Q9BRX9; P21333-2: FLNA; NbExp=3; IntAct=EBI-7705033, EBI-9641086; CC Q9BRX9; O43559: FRS3; NbExp=3; IntAct=EBI-7705033, EBI-725515; CC Q9BRX9; P14136: GFAP; NbExp=3; IntAct=EBI-7705033, EBI-744302; CC Q9BRX9; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-7705033, EBI-11975289; CC Q9BRX9; P49639: HOXA1; NbExp=3; IntAct=EBI-7705033, EBI-740785; CC Q9BRX9; P04792: HSPB1; NbExp=4; IntAct=EBI-7705033, EBI-352682; CC Q9BRX9; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-7705033, EBI-1055254; CC Q9BRX9; Q7L273: KCTD9; NbExp=3; IntAct=EBI-7705033, EBI-4397613; CC Q9BRX9; Q14145: KEAP1; NbExp=7; IntAct=EBI-7705033, EBI-751001; CC Q9BRX9; O60333-2: KIF1B; NbExp=3; IntAct=EBI-7705033, EBI-10975473; CC Q9BRX9; O14901: KLF11; NbExp=3; IntAct=EBI-7705033, EBI-948266; CC Q9BRX9; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-7705033, EBI-2341787; CC Q9BRX9; P19404: NDUFV2; NbExp=3; IntAct=EBI-7705033, EBI-713665; CC Q9BRX9; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-7705033, EBI-12025760; CC Q9BRX9; D3DTS7: PMP22; NbExp=3; IntAct=EBI-7705033, EBI-25882629; CC Q9BRX9; Q9Y3C6: PPIL1; NbExp=2; IntAct=EBI-7705033, EBI-2557649; CC Q9BRX9; O43741: PRKAB2; NbExp=3; IntAct=EBI-7705033, EBI-1053424; CC Q9BRX9; Q6P2Q9: PRPF8; NbExp=2; IntAct=EBI-7705033, EBI-538479; CC Q9BRX9; P60891: PRPS1; NbExp=3; IntAct=EBI-7705033, EBI-749195; CC Q9BRX9; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-7705033, EBI-396669; CC Q9BRX9; Q15427: SF3B4; NbExp=2; IntAct=EBI-7705033, EBI-348469; CC Q9BRX9; P09234: SNRPC; NbExp=2; IntAct=EBI-7705033, EBI-766589; CC Q9BRX9; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-7705033, EBI-5235340; CC Q9BRX9; Q13148: TARDBP; NbExp=6; IntAct=EBI-7705033, EBI-372899; CC Q9BRX9; O43711: TLX3; NbExp=3; IntAct=EBI-7705033, EBI-3939165; CC Q9BRX9; P02766: TTR; NbExp=3; IntAct=EBI-7705033, EBI-711909; CC Q9BRX9; Q9BZL1: UBL5; NbExp=2; IntAct=EBI-7705033, EBI-607755; CC Q9BRX9; Q08AM6: VAC14; NbExp=3; IntAct=EBI-7705033, EBI-2107455; CC Q9BRX9; O76024: WFS1; NbExp=3; IntAct=EBI-7705033, EBI-720609; CC Q9BRX9; P36508: ZNF76; NbExp=3; IntAct=EBI-7705033, EBI-7254550; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. CC Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the WD repeat MORG1 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK223195; BAD96915.1; -; mRNA. DR EMBL; AK314164; BAG36848.1; -; mRNA. DR EMBL; CH471106; EAW84282.1; -; Genomic_DNA. DR EMBL; BC005870; AAH05870.1; -; mRNA. DR CCDS; CCDS12275.1; -. DR RefSeq; NP_001093207.1; NM_001099737.2. DR RefSeq; NP_115708.1; NM_032332.3. DR AlphaFoldDB; Q9BRX9; -. DR SMR; Q9BRX9; -. DR BioGRID; 124019; 190. DR CORUM; Q9BRX9; -. DR IntAct; Q9BRX9; 154. DR MINT; Q9BRX9; -. DR STRING; 9606.ENSP00000402653; -. DR iPTMnet; Q9BRX9; -. DR PhosphoSitePlus; Q9BRX9; -. DR BioMuta; WDR83; -. DR DMDM; 74761224; -. DR EPD; Q9BRX9; -. DR jPOST; Q9BRX9; -. DR MassIVE; Q9BRX9; -. DR MaxQB; Q9BRX9; -. DR PaxDb; Q9BRX9; -. DR PeptideAtlas; Q9BRX9; -. DR PRIDE; Q9BRX9; -. DR ProteomicsDB; 78851; -. DR Antibodypedia; 26076; 221 antibodies from 29 providers. DR DNASU; 84292; -. DR Ensembl; ENST00000418543.8; ENSP00000402653.3; ENSG00000123154.12. DR GeneID; 84292; -. DR KEGG; hsa:84292; -. DR MANE-Select; ENST00000418543.8; ENSP00000402653.3; NM_001099737.3; NP_001093207.1. DR UCSC; uc002mue.5; human. DR CTD; 84292; -. DR DisGeNET; 84292; -. DR GeneCards; WDR83; -. DR HGNC; HGNC:32672; WDR83. DR HPA; ENSG00000123154; Low tissue specificity. DR neXtProt; NX_Q9BRX9; -. DR OpenTargets; ENSG00000123154; -. DR PharmGKB; PA165394765; -. DR VEuPathDB; HostDB:ENSG00000123154; -. DR eggNOG; KOG0316; Eukaryota. DR GeneTree; ENSGT00940000159016; -. DR InParanoid; Q9BRX9; -. DR OMA; MCWDIRT; -. DR OrthoDB; 1090342at2759; -. DR PhylomeDB; Q9BRX9; -. DR TreeFam; TF314828; -. DR PathwayCommons; Q9BRX9; -. DR Reactome; R-HSA-5674135; MAP2K and MAPK activation. DR SignaLink; Q9BRX9; -. DR SIGNOR; Q9BRX9; -. DR BioGRID-ORCS; 84292; 308 hits in 1088 CRISPR screens. DR ChiTaRS; WDR83; human. DR GenomeRNAi; 84292; -. DR Pharos; Q9BRX9; Tbio. DR PRO; PR:Q9BRX9; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; Q9BRX9; protein. DR Bgee; ENSG00000123154; Expressed in right hemisphere of cerebellum and 117 other tissues. DR ExpressionAtlas; Q9BRX9; baseline and differential. DR Genevisible; Q9BRX9; HS. DR GO; GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB. DR GO; GO:0010008; C:endosome membrane; TAS:Reactome. DR GO; GO:0005681; C:spliceosomal complex; IDA:UniProtKB. DR GO; GO:0090594; P:inflammatory response to wounding; IEA:Ensembl. DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IDA:UniProtKB. DR GO; GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl. DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl. DR GO; GO:0000375; P:RNA splicing, via transesterification reactions; IDA:UniProtKB. DR Gene3D; 2.130.10.10; -; 1. DR InterPro; IPR020472; G-protein_beta_WD-40_rep. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR InterPro; IPR001680; WD40_repeat. DR InterPro; IPR019775; WD40_repeat_CS. DR InterPro; IPR036322; WD40_repeat_dom_sf. DR Pfam; PF00400; WD40; 4. DR PRINTS; PR00320; GPROTEINBRPT. DR SMART; SM00320; WD40; 7. DR SUPFAM; SSF50978; SSF50978; 1. DR PROSITE; PS00678; WD_REPEATS_1; 2. DR PROSITE; PS50082; WD_REPEATS_2; 3. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. PE 1: Evidence at protein level; KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome; KW Repeat; Spliceosome; WD repeat. FT CHAIN 1..315 FT /note="WD repeat domain-containing protein 83" FT /id="PRO_0000235263" FT REPEAT 23..62 FT /note="WD 1" FT REPEAT 65..104 FT /note="WD 2" FT REPEAT 107..146 FT /note="WD 3" FT REPEAT 151..188 FT /note="WD 4" FT REPEAT 190..228 FT /note="WD 5" FT REPEAT 231..272 FT /note="WD 6" FT REPEAT 275..313 FT /note="WD 7" FT VARIANT 278 FT /note="G -> S (in dbSNP:rs34373915)" FT /id="VAR_053410" FT VARIANT 304 FT /note="R -> Q (in dbSNP:rs35092999)" FT /id="VAR_053411" FT CONFLICT 162 FT /note="S -> L (in Ref. 2; BAD96915)" FT /evidence="ECO:0000305" FT CONFLICT 278 FT /note="G -> D (in Ref. 2; BAD96915)" FT /evidence="ECO:0000305" SQ SEQUENCE 315 AA; 34343 MW; CF5F59C1FAA432FE CRC64; MAFPEPKPRP PELPQKRLKT LDCGQGAVRA VRFNVDGNYC LTCGSDKTLK LWNPLRGTLL RTYSGHGYEV LDAAGSFDNS SLCSGGGDKA VVLWDVASGQ VVRKFRGHAG KVNTVQFNEE ATVILSGSID SSIRCWDCRS RRPEPVQTLD EARDGVSSVK VSDHEILAGS VDGRVRRYDL RMGQLFSDYV GSPITCTCFS RDGQCTLVSS LDSTLRLLDK DTGELLGEYK GHKNQEYKLD CCLSERDTHV VSCSEDGKVF FWDLVEGALA LALPVGSGVV QSLAYHPTEP CLLTAMGGSV QCWREEAYEA EDGAG //