ID LZTS2_HUMAN Reviewed; 669 AA. AC Q9BRK4; B1AL14; D3DR72; Q8N3I0; Q96J79; Q96JL2; DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2004, sequence version 2. DT 22-NOV-2017, entry version 133. DE RecName: Full=Leucine zipper putative tumor suppressor 2 {ECO:0000255|HAMAP-Rule:MF_03026}; DE Short=hLZTS2; DE AltName: Full=Protein LAPSER1 {ECO:0000255|HAMAP-Rule:MF_03026}; GN Name=LZTS2 {ECO:0000255|HAMAP-Rule:MF_03026}; GN Synonyms=KIAA1813, LAPSER1 {ECO:0000255|HAMAP-Rule:MF_03026}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=11347906; DOI=10.1093/dnares/8.2.85; RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. XX. RT The complete sequences of 100 new cDNA clones from brain which code RT for large proteins in vitro."; RL DNA Res. 8:85-95(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain, and Uterus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 26-669, ALTERNATIVE SPLICING, AND TISSUE RP SPECIFICITY. RC TISSUE=Prostate; RX PubMed=11709705; DOI=10.1038/sj.onc.1204866; RA Cabeza-Arvelaiz Y., Thompson T.C., Sepulveda J.L., Chinault A.C.; RT "LAPSER1: a novel candidate tumor suppressor gene from 10q24.3."; RL Oncogene 20:6707-6717(2001). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 139-669. RC TISSUE=Amygdala; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [7] RP FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, NUCLEAR RP EXPORT SIGNAL, AND MUTAGENESIS OF LEU-638 AND LEU-640. RX PubMed=17000760; DOI=10.1128/MCB.01031-06; RA Thyssen G., Li T.-H., Lehmann L., Zhuo M., Sharma M., Sun Z.; RT "LZTS2 is a novel beta-catenin-interacting protein and regulates the RT nuclear export of beta-catenin."; RL Mol. Cell. Biol. 26:8857-8867(2006). RN [8] RP FUNCTION, INTERACTION WITH GAMMA-TUBULIN; KIF23 AND KATNB1, AND RP SUBCELLULAR LOCATION. RX PubMed=17351128; DOI=10.1096/fj.06-7254com; RA Sudo H., Maru Y.; RT "LAPSER1 is a putative cytokinetic tumor suppressor that shows the RT same centrosome and midbody subcellular localization pattern as p80 RT katanin."; RL FASEB J. 21:2086-2100(2007). RN [9] RP FUNCTION, AND INDUCTION. RX PubMed=17950943; DOI=10.1016/j.bbamcr.2007.08.005; RA Cho H.H., Joo H.J., Song J.S., Bae Y.C., Jung J.S.; RT "Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated RT by lzts2 in human adipose tissue-derived mesenchymal stem cells."; RL Biochim. Biophys. Acta 1783:419-428(2008). RN [10] RP FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=18490357; DOI=10.1093/hmg/ddn153; RA Sudo H., Maru Y.; RT "LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the RT inhibition of katanin-mediated microtubule severing."; RL Hum. Mol. Genet. 17:2524-2540(2008). RN [11] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., RA Blagoev B.; RT "System-wide temporal characterization of the proteome and RT phosphoproteome of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [12] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [13] RP VARIANTS [LARGE SCALE ANALYSIS] HIS-121 AND ARG-291. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., RA Vogelstein B., Kinzler K.W., Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal RT cancers."; RL Science 314:268-274(2006). CC -!- FUNCTION: Negative regulator of katanin-mediated microtubule CC severing and release from the centrosome. Required for central CC spindle formation and the completion of cytokinesis. May CC negatively regulate axonal outgrowth by preventing the formation CC of microtubule bundles that are necessary for transport within the CC elongating axon. Negative regulator of the Wnt signaling pathway. CC Represses beta-catenin-mediated transcriptional activation by CC promoting the nuclear exclusion of beta-catenin. CC {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, CC ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, CC ECO:0000269|PubMed:18490357}. CC -!- SUBUNIT: Interacts with KATNB1. Also interacts with CTNNB1, gamma- CC tubulin and KIF23. {ECO:0000255|HAMAP-Rule:MF_03026, CC ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128}. CC -!- INTERACTION: CC A8K932:-; NbExp=3; IntAct=EBI-741037, EBI-10174671; CC P0C206:- (xeno); NbExp=4; IntAct=EBI-741037, EBI-9675596; CC Q95HA4:-; NbExp=3; IntAct=EBI-741037, EBI-10236795; CC Q9H6F0:-; NbExp=3; IntAct=EBI-741037, EBI-10307481; CC Q9ULW3:ABT1; NbExp=3; IntAct=EBI-741037, EBI-2602396; CC Q8WTP8:AEN; NbExp=3; IntAct=EBI-741037, EBI-8637627; CC Q96IX9:ANKRD36BP1; NbExp=3; IntAct=EBI-741037, EBI-744859; CC Q9BXS5:AP1M1; NbExp=3; IntAct=EBI-741037, EBI-541426; CC A7KAX9:ARHGAP32; NbExp=3; IntAct=EBI-741037, EBI-308663; CC Q9H6L4:ARMC7; NbExp=3; IntAct=EBI-741037, EBI-742909; CC Q8N5M1:ATPAF2; NbExp=6; IntAct=EBI-741037, EBI-1166928; CC Q8TBE0:BAHD1; NbExp=6; IntAct=EBI-741037, EBI-742750; CC Q9BXY8:BEX2; NbExp=3; IntAct=EBI-741037, EBI-745073; CC Q13895:BYSL; NbExp=5; IntAct=EBI-741037, EBI-358049; CC Q9NVL8:C14orf105; NbExp=3; IntAct=EBI-741037, EBI-10238351; CC Q9NX04:C1orf109; NbExp=5; IntAct=EBI-741037, EBI-8643161; CC Q9H7E9:C8orf33; NbExp=3; IntAct=EBI-741037, EBI-715389; CC Q9H257:CARD9; NbExp=3; IntAct=EBI-741037, EBI-751319; CC Q9HC52:CBX8; NbExp=5; IntAct=EBI-741037, EBI-712912; CC P24863:CCNC; NbExp=3; IntAct=EBI-741037, EBI-395261; CC P51959:CCNG1; NbExp=3; IntAct=EBI-741037, EBI-3905829; CC O75909:CCNK; NbExp=3; IntAct=EBI-741037, EBI-739806; CC Q9UJX2:CDC23; NbExp=3; IntAct=EBI-741037, EBI-396137; CC Q07002:CDK18; NbExp=3; IntAct=EBI-741037, EBI-746238; CC Q8IVW4:CDKL3; NbExp=3; IntAct=EBI-741037, EBI-3919850; CC Q8IYX8:CEP57L1; NbExp=3; IntAct=EBI-741037, EBI-1104570; CC Q8IYX8-2:CEP57L1; NbExp=3; IntAct=EBI-741037, EBI-10181988; CC Q8IYR0:CFAP206; NbExp=3; IntAct=EBI-741037, EBI-749051; CC Q9NX63:CHCHD3; NbExp=3; IntAct=EBI-741037, EBI-743375; CC Q8N3C7:CLIP4; NbExp=3; IntAct=EBI-741037, EBI-5655540; CC Q8NE01:CNNM3; NbExp=3; IntAct=EBI-741037, EBI-741032; CC Q8NE01-3:CNNM3; NbExp=3; IntAct=EBI-741037, EBI-10269984; CC Q2TBE0:CWF19L2; NbExp=3; IntAct=EBI-741037, EBI-5453285; CC Q96GG9:DCUN1D1; NbExp=5; IntAct=EBI-741037, EBI-740086; CC Q9BY27:DGCR6L; NbExp=3; IntAct=EBI-741037, EBI-742953; CC Q13627:DYRK1A; NbExp=3; IntAct=EBI-741037, EBI-1053596; CC Q9Y463:DYRK1B; NbExp=3; IntAct=EBI-741037, EBI-634187; CC Q92630:DYRK2; NbExp=3; IntAct=EBI-741037, EBI-749432; CC Q08426:EHHADH; NbExp=3; IntAct=EBI-741037, EBI-2339219; CC O15371:EIF3D; NbExp=3; IntAct=EBI-741037, EBI-353818; CC O60573:EIF4E2; NbExp=3; IntAct=EBI-741037, EBI-398610; CC Q9BTL3:FAM103A1; NbExp=3; IntAct=EBI-741037, EBI-744023; CC O95990-3:FAM107A; NbExp=3; IntAct=EBI-741037, EBI-10192902; CC Q9H5Z6:FAM124B; NbExp=3; IntAct=EBI-741037, EBI-741626; CC Q3B820:FAM161A; NbExp=5; IntAct=EBI-741037, EBI-719941; CC Q5TZK3:FAM74A6; NbExp=3; IntAct=EBI-741037, EBI-10247271; CC Q9NW38:FANCL; NbExp=3; IntAct=EBI-741037, EBI-2339898; CC Q8TES7-6:FBF1; NbExp=3; IntAct=EBI-741037, EBI-10244131; CC Q96JP0:FEM1C; NbExp=3; IntAct=EBI-741037, EBI-2515330; CC P61328:FGF12; NbExp=3; IntAct=EBI-741037, EBI-6657662; CC O75344:FKBP6; NbExp=6; IntAct=EBI-741037, EBI-744771; CC Q9BVV2:FNDC11; NbExp=3; IntAct=EBI-741037, EBI-744935; CC Q14331:FRG1; NbExp=3; IntAct=EBI-741037, EBI-2515248; CC Q96NE9:FRMD6; NbExp=3; IntAct=EBI-741037, EBI-741729; CC P15976-2:GATA1; NbExp=3; IntAct=EBI-741037, EBI-9090198; CC Q96CN9:GCC1; NbExp=3; IntAct=EBI-741037, EBI-746252; CC P55040:GEM; NbExp=7; IntAct=EBI-741037, EBI-744104; CC Q8NEA9:GMCL1P1; NbExp=5; IntAct=EBI-741037, EBI-745707; CC Q9NVN8:GNL3L; NbExp=3; IntAct=EBI-741037, EBI-746682; CC O95872:GPANK1; NbExp=3; IntAct=EBI-741037, EBI-751540; CC Q9NWQ4:GPATCH2L; NbExp=3; IntAct=EBI-741037, EBI-5666657; CC P62993:GRB2; NbExp=3; IntAct=EBI-741037, EBI-401755; CC Q8TCT9:HM13; NbExp=3; IntAct=EBI-741037, EBI-347472; CC Q9NSB8:HOMER2; NbExp=3; IntAct=EBI-741037, EBI-2126733; CC P17482:HOXB9; NbExp=3; IntAct=EBI-741037, EBI-745290; CC P10809:HSPD1; NbExp=7; IntAct=EBI-741037, EBI-352528; CC Q92993:KAT5; NbExp=5; IntAct=EBI-741037, EBI-399080; CC Q674X7:KAZN; NbExp=3; IntAct=EBI-741037, EBI-949239; CC Q9H0B3:KIAA1683; NbExp=3; IntAct=EBI-741037, EBI-745878; CC Q9BVG8:KIFC3; NbExp=3; IntAct=EBI-741037, EBI-2125614; CC P52292:KPNA2; NbExp=3; IntAct=EBI-741037, EBI-349938; CC Q14847:LASP1; NbExp=3; IntAct=EBI-741037, EBI-742828; CC P06239:LCK; NbExp=3; IntAct=EBI-741037, EBI-1348; CC Q96GY3:LIN37; NbExp=3; IntAct=EBI-741037, EBI-748884; CC P25800:LMO1; NbExp=3; IntAct=EBI-741037, EBI-8639312; CC P25791:LMO2; NbExp=3; IntAct=EBI-741037, EBI-739696; CC Q8TAP4-4:LMO3; NbExp=4; IntAct=EBI-741037, EBI-11742507; CC Q8N8X9:MAB21L3; NbExp=5; IntAct=EBI-741037, EBI-10268010; CC O15481:MAGEB4; NbExp=3; IntAct=EBI-741037, EBI-751857; CC Q9Y316:MEMO1; NbExp=3; IntAct=EBI-741037, EBI-1104564; CC Q9UBU8:MORF4L1; NbExp=3; IntAct=EBI-741037, EBI-399246; CC Q15014:MORF4L2; NbExp=3; IntAct=EBI-741037, EBI-399257; CC Q6PF18:MORN3; NbExp=3; IntAct=EBI-741037, EBI-9675802; CC P00540:MOS; NbExp=3; IntAct=EBI-741037, EBI-1757866; CC Q13330:MTA1; NbExp=3; IntAct=EBI-741037, EBI-714236; CC P52298:NCBP2; NbExp=3; IntAct=EBI-741037, EBI-464729; CC O43639:NCK2; NbExp=3; IntAct=EBI-741037, EBI-713635; CC O76041:NEBL; NbExp=3; IntAct=EBI-741037, EBI-2880203; CC Q9HC98:NEK6; NbExp=3; IntAct=EBI-741037, EBI-740364; CC Q9Y221:NIP7; NbExp=3; IntAct=EBI-741037, EBI-749003; CC Q96DC9:OTUB2; NbExp=3; IntAct=EBI-741037, EBI-746259; CC Q99569:PKP4; NbExp=3; IntAct=EBI-741037, EBI-726447; CC Q494U1:PLEKHN1; NbExp=3; IntAct=EBI-741037, EBI-10241513; CC Q8WUT1:POLDIP3; NbExp=5; IntAct=EBI-741037, EBI-10276663; CC O15160:POLR1C; NbExp=3; IntAct=EBI-741037, EBI-1055079; CC Q6NYC8:PPP1R18; NbExp=3; IntAct=EBI-741037, EBI-2557469; CC O60828:PQBP1; NbExp=3; IntAct=EBI-741037, EBI-713867; CC O43741:PRKAB2; NbExp=3; IntAct=EBI-741037, EBI-1053424; CC Q8WWY3:PRPF31; NbExp=3; IntAct=EBI-741037, EBI-1567797; CC P0CG20:PRR35; NbExp=4; IntAct=EBI-741037, EBI-11986293; CC P25786:PSMA1; NbExp=3; IntAct=EBI-741037, EBI-359352; CC P47897:QARS; NbExp=5; IntAct=EBI-741037, EBI-347462; CC P47897-2:QARS; NbExp=3; IntAct=EBI-741037, EBI-10209725; CC P63000:RAC1; NbExp=3; IntAct=EBI-741037, EBI-413628; CC O75771:RAD51D; NbExp=8; IntAct=EBI-741037, EBI-1055693; CC Q96T37:RBM15; NbExp=3; IntAct=EBI-741037, EBI-2514922; CC Q96IZ5:RBM41; NbExp=3; IntAct=EBI-741037, EBI-740773; CC Q9P2K3:RCOR3; NbExp=3; IntAct=EBI-741037, EBI-743428; CC Q9BSD3:RHNO1; NbExp=3; IntAct=EBI-741037, EBI-9658624; CC Q13671:RIN1; NbExp=5; IntAct=EBI-741037, EBI-366017; CC Q9H4P4:RNF41; NbExp=3; IntAct=EBI-741037, EBI-2130266; CC Q14D33:RTP5; NbExp=3; IntAct=EBI-741037, EBI-10217913; CC Q06455-4:RUNX1T1; NbExp=3; IntAct=EBI-741037, EBI-10224192; CC Q9NUL5:RYDEN; NbExp=3; IntAct=EBI-741037, EBI-10313866; CC Q9BWG6:SCNM1; NbExp=3; IntAct=EBI-741037, EBI-748391; CC Q6NXQ0:SFRS2; NbExp=3; IntAct=EBI-741037, EBI-10251550; CC Q9H788:SH2D4A; NbExp=3; IntAct=EBI-741037, EBI-747035; CC Q08AM8:SH3RF2; NbExp=3; IntAct=EBI-741037, EBI-10225873; CC Q05CH4:SLC15A3; NbExp=3; IntAct=EBI-741037, EBI-10223741; CC P12236:SLC25A6; NbExp=3; IntAct=EBI-741037, EBI-356254; CC O95391:SLU7; NbExp=3; IntAct=EBI-741037, EBI-750559; CC Q9BZL3:SMIM3; NbExp=3; IntAct=EBI-741037, EBI-741850; CC Q13573:SNW1; NbExp=3; IntAct=EBI-741037, EBI-632715; CC Q8N9S9:SNX31; NbExp=3; IntAct=EBI-741037, EBI-9380649; CC Q9UM82:SPATA2; NbExp=3; IntAct=EBI-741037, EBI-744066; CC Q86W54:SPATA24; NbExp=3; IntAct=EBI-741037, EBI-3916986; CC Q9H0A9:SPATC1L; NbExp=3; IntAct=EBI-741037, EBI-372911; CC Q9UQ90:SPG7; NbExp=3; IntAct=EBI-741037, EBI-717201; CC Q8WUK8:STAC; NbExp=3; IntAct=EBI-741037, EBI-10276615; CC Q8IYB8:SUPV3L1; NbExp=3; IntAct=EBI-741037, EBI-2876787; CC O43463:SUV39H1; NbExp=5; IntAct=EBI-741037, EBI-349968; CC P03410:tax (xeno); NbExp=5; IntAct=EBI-741037, EBI-9676218; CC Q9P0N9:TBC1D7; NbExp=3; IntAct=EBI-741037, EBI-3258000; CC Q15560:TCEA2; NbExp=3; IntAct=EBI-741037, EBI-710310; CC Q9BT92:TCHP; NbExp=3; IntAct=EBI-741037, EBI-740781; CC D3DUQ6:TEAD4; NbExp=3; IntAct=EBI-741037, EBI-10176734; CC Q9P2Z0:THAP10; NbExp=3; IntAct=EBI-741037, EBI-745404; CC Q9BT49:THAP7; NbExp=5; IntAct=EBI-741037, EBI-741350; CC Q96KP6:TNIP3; NbExp=5; IntAct=EBI-741037, EBI-2509913; CC Q14134:TRIM29; NbExp=4; IntAct=EBI-741037, EBI-702370; CC Q8IWZ5:TRIM42; NbExp=3; IntAct=EBI-741037, EBI-5235829; CC Q99598:TSNAX; NbExp=5; IntAct=EBI-741037, EBI-742638; CC Q5W5X9:TTC23; NbExp=3; IntAct=EBI-741037, EBI-6447954; CC P83876:TXNL4A; NbExp=3; IntAct=EBI-741037, EBI-746539; CC Q15853:USF2; NbExp=3; IntAct=EBI-741037, EBI-1055994; CC O75604:USP2; NbExp=5; IntAct=EBI-741037, EBI-743272; CC Q08E77:UTP14C; NbExp=4; IntAct=EBI-741037, EBI-10225961; CC Q96HA8:WDYHV1; NbExp=3; IntAct=EBI-741037, EBI-741158; CC Q06250:WT1-AS; NbExp=3; IntAct=EBI-741037, EBI-10223946; CC P24278:ZBTB25; NbExp=3; IntAct=EBI-741037, EBI-739899; CC Q8N5A5:ZGPAT; NbExp=3; IntAct=EBI-741037, EBI-3439227; CC Q8N5A5-2:ZGPAT; NbExp=5; IntAct=EBI-741037, EBI-10183064; CC Q9BRR0:ZKSCAN3; NbExp=3; IntAct=EBI-741037, EBI-1965777; CC Q96NC0:ZMAT2; NbExp=3; IntAct=EBI-741037, EBI-2682299; CC Q96E35:ZMYND19; NbExp=4; IntAct=EBI-741037, EBI-746595; CC P17024:ZNF20; NbExp=3; IntAct=EBI-741037, EBI-717634; CC P15622-3:ZNF250; NbExp=3; IntAct=EBI-741037, EBI-10177272; CC Q8TAU3:ZNF417; NbExp=5; IntAct=EBI-741037, EBI-740727; CC Q9BUY5:ZNF426; NbExp=3; IntAct=EBI-741037, EBI-743265; CC Q9NWS9-2:ZNF446; NbExp=5; IntAct=EBI-741037, EBI-740232; CC Q9ULM2:ZNF490; NbExp=3; IntAct=EBI-741037, EBI-1105370; CC Q7Z3I7:ZNF572; NbExp=5; IntAct=EBI-741037, EBI-10172590; CC Q9P0T4:ZNF581; NbExp=4; IntAct=EBI-741037, EBI-745520; CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, CC microtubule organizing center, centrosome. Note=Localized to the CC centrosome throughout the cell cycle. Localized to the midbody in CC cells undergoing cytokinesis. CC -!- TISSUE SPECIFICITY: Highly expressed in prostate and testis, and CC at slightly lower levels in spleen, thymus, uterus, small CC intestine and colon. {ECO:0000269|PubMed:11709705}. CC -!- INDUCTION: By inhibition of NF-kappa-B signaling. CC {ECO:0000269|PubMed:17950943}. CC -!- SIMILARITY: Belongs to the LZTS2 family. {ECO:0000255|HAMAP- CC Rule:MF_03026}. CC -!- SEQUENCE CAUTION: CC Sequence=BAB47442.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB058716; BAB47442.1; ALT_INIT; mRNA. DR EMBL; AL133215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471066; EAW49790.1; -; Genomic_DNA. DR EMBL; CH471066; EAW49791.1; -; Genomic_DNA. DR EMBL; CH471066; EAW49792.1; -; Genomic_DNA. DR EMBL; BC006212; AAH06212.2; -; mRNA. DR EMBL; BC058938; AAH58938.1; -; mRNA. DR EMBL; AY029201; AAK31577.1; -; mRNA. DR EMBL; AL834338; CAD39005.1; -; mRNA. DR CCDS; CCDS7507.1; -. DR RefSeq; NP_001305028.1; NM_001318099.1. DR RefSeq; NP_001305029.1; NM_001318100.1. DR RefSeq; NP_001305030.1; NM_001318101.1. DR RefSeq; NP_115805.1; NM_032429.3. DR RefSeq; XP_005270279.1; XM_005270222.4. DR RefSeq; XP_016872269.1; XM_017016780.1. DR UniGene; Hs.523221; -. DR UniGene; Hs.734981; -. DR ProteinModelPortal; Q9BRK4; -. DR SMR; Q9BRK4; -. DR BioGrid; 124083; 269. DR IntAct; Q9BRK4; 252. DR MINT; MINT-1199317; -. DR STRING; 9606.ENSP00000359240; -. DR iPTMnet; Q9BRK4; -. DR PhosphoSitePlus; Q9BRK4; -. DR BioMuta; LZTS2; -. DR DMDM; 46396501; -. DR EPD; Q9BRK4; -. DR MaxQB; Q9BRK4; -. DR PaxDb; Q9BRK4; -. DR PeptideAtlas; Q9BRK4; -. DR PRIDE; Q9BRK4; -. DR DNASU; 84445; -. DR Ensembl; ENST00000370220; ENSP00000359240; ENSG00000107816. DR Ensembl; ENST00000370223; ENSP00000359243; ENSG00000107816. DR GeneID; 84445; -. DR KEGG; hsa:84445; -. DR UCSC; uc001ksj.4; human. DR CTD; 84445; -. DR DisGeNET; 84445; -. DR EuPathDB; HostDB:ENSG00000107816.17; -. DR GeneCards; LZTS2; -. DR HGNC; HGNC:29381; LZTS2. DR HPA; HPA044956; -. DR MIM; 610454; gene. DR neXtProt; NX_Q9BRK4; -. DR OpenTargets; ENSG00000107816; -. DR PharmGKB; PA134944540; -. DR eggNOG; ENOG410IGJE; Eukaryota. DR eggNOG; ENOG4111JZA; LUCA. DR GeneTree; ENSGT00510000046769; -. DR HOGENOM; HOG000230889; -. DR HOVERGEN; HBG052381; -. DR InParanoid; Q9BRK4; -. DR OMA; RRCATFE; -. DR OrthoDB; EOG091G03L2; -. DR PhylomeDB; Q9BRK4; -. DR TreeFam; TF331420; -. DR ChiTaRS; LZTS2; human. DR GenomeRNAi; 84445; -. DR PRO; PR:Q9BRK4; -. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000107816; -. DR CleanEx; HS_LZTS2; -. DR ExpressionAtlas; Q9BRK4; baseline and differential. DR Genevisible; Q9BRK4; HS. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW. DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IDA:HPA. DR GO; GO:0031982; C:vesicle; IDA:BHF-UCL. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0001822; P:kidney development; IEA:Ensembl. DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl. DR GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl. DR GO; GO:1900181; P:negative regulation of protein localization to nucleus; IEA:Ensembl. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW. DR HAMAP; MF_03026; LZTS2; 1. DR InterPro; IPR028597; LZTS2. DR PANTHER; PTHR19354:SF4; PTHR19354:SF4; 1. PE 1: Evidence at protein level; KW Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; KW Cytoskeleton; Microtubule; Mitosis; Phosphoprotein; Polymorphism; KW Reference proteome; Wnt signaling pathway. FT CHAIN 1 669 Leucine zipper putative tumor suppressor FT 2. FT /FTId=PRO_0000182974. FT REGION 1 332 Required for centrosomal localization. FT {ECO:0000250}. FT REGION 447 669 Sufficient for interaction with CTNNB1. FT {ECO:0000269|PubMed:17000760}. FT REGION 450 669 Sufficient for interaction with KATNB1 FT and for inhibition of katanin-mediated FT microtubule severing. {ECO:0000250}. FT COILED 328 649 {ECO:0000255|HAMAP-Rule:MF_03026}. FT MOTIF 631 640 Nuclear export signal. FT COMPBIAS 188 306 Ser-rich. FT MOD_RES 249 249 Phosphoserine. FT {ECO:0000250|UniProtKB:Q91YU6}. FT MOD_RES 296 296 Phosphoserine. FT {ECO:0000250|UniProtKB:Q91YU6}. FT MOD_RES 570 570 Phosphoserine. FT {ECO:0000244|PubMed:21406692, FT ECO:0000244|PubMed:23186163}. FT VARIANT 121 121 R -> H (in a colorectal cancer sample; FT somatic mutation; dbSNP:rs367898512). FT {ECO:0000269|PubMed:16959974}. FT /FTId=VAR_036364. FT VARIANT 291 291 G -> R (in a breast cancer sample; FT somatic mutation). FT {ECO:0000269|PubMed:16959974}. FT /FTId=VAR_036365. FT VARIANT 299 299 R -> W (in dbSNP:rs2275381). FT /FTId=VAR_018277. FT MUTAGEN 638 638 L->A: Induces nuclear accumulation. FT Impairs nuclear exclusion of beta- FT catenin; when associated with A-640. FT {ECO:0000269|PubMed:17000760}. FT MUTAGEN 640 640 L->A: Induces nuclear accumulation. FT Impairs nuclear exclusion of beta- FT catenin; when associated with A-38. FT {ECO:0000269|PubMed:17000760}. FT CONFLICT 289 289 V -> L (in Ref. 4; AAH58938). FT {ECO:0000305}. SQ SEQUENCE 669 AA; 72759 MW; 1274FD9A36A217E6 CRC64; MAIVQTLPVP LEPAPEAATA PQAPVMGSVS SLISGRPCPG GPAPPRHHGP PGPTFFRQQD GLLRGGYEAQ EPLCPAVPPR KAVPVTSFTY INEDFRTESP PSPSSDVEDA REQRAHNAHL RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP VLPKPRGAPS LPSFMGPRAT GLSGSQGSLT QLFGGPASSS SSSSSSSAAD KPLAFSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTT SSPGGHLPSH GSGRGALPGP ARGVPTGPSH SDSGRSSSSK STGSLGGRVA GGLLGSGTRA SPDSSSCGER SPPPPPPPPS DEALLHCVLE GKLRDREAEL QQLRDSLDEN EATMCQAYEE RQRHWQRERE ALREDCAAQA QRAQRAQQLL QLQVFQLQQE KRQLQDDFAQ LLQEREQLER RCATLEREQR ELGPRLEETK WEVCQKSGEI SLLKQQLKES QAELVQKGSE LVALRVALRE ARATLRVSEG RARGLQEAAR ARELELEACS QELQRHRQEA EQLREKAGQL DAEAAGLREP PVPPATADPF LLAESDEAKV QRAAAGVGGS LRAQVERLRV ELQRERRRGE EQRDSFEGER LAWQAEKEQV IRYQKQLQHN YIQMYRRNRQ LEQELQQLSL ELEARELADL GLAEQAPCIC LEEITATEI //