ID   MEP50_HUMAN    STANDARD;      PRT;   342 AA.
AC   Q9BQA1; Q96GK4; Q9BWY3;
DT   20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   05-SEP-2006, entry version 29.
DE   Methylosome protein 50 (MEP50 protein) (WD repeat protein 77).
GN   Name=WDR77; Synonyms=MEP50;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=21864234; PubMed=11756452; DOI=10.1074/jbc.M109984200;
RA   Friesen W.J., Wyce A., Paushkin S., Abel L., Rappsilber J., Mann M.,
RA   Dreyfuss G.;
RT   "A novel WD repeat protein component of the methylosome binds Sm
RT   proteins.";
RL   J. Biol. Chem. 277:8243-8247(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I.,
RA   Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon, Lung, and Skin;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- FUNCTION: The methylosome may regulate an early step in the
CC       assembly of U snRNPs, possibly the transfer of Sm proteins to the
CC       SMN-complex.
CC   -!- SUBUNIT: Forms, at least, homodimers and homotetramers. Component
CC       of the methylosome, a 20S complex containing at least pICLn, SKB1
CC       and MEP50. Interacts with SKB1 and with Sm proteins.
CC   -!- SIMILARITY: Contains 5 WD repeats.
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DR   EMBL; AF478464; AAL79917.1; -; mRNA.
DR   EMBL; AL390195; CAC36041.1; -; Genomic_DNA.
DR   EMBL; BC001679; AAH01679.1; -; mRNA.
DR   EMBL; BC006477; AAH06477.1; -; mRNA.
DR   EMBL; BC009411; AAH09411.1; -; mRNA.
DR   EMBL; BC011778; AAH11778.1; -; mRNA.
DR   EMBL; BC016946; AAH16946.1; -; mRNA.
DR   UniGene; Hs.204773; -.
DR   Ensembl; ENSG00000116455; Homo sapiens.
DR   HGNC; HGNC:29652; WDR77.
DR   LinkHub; Q9BQA1; -.
DR   ArrayExpress; Q9BQA1; -.
DR   RZPD-ProtExp; IOH10338; -.
DR   RZPD-ProtExp; IOH14800; -.
DR   RZPD-ProtExp; V0941; -.
DR   InterPro; IPR011045; N2O_reductase_N.
DR   InterPro; IPR001680; WD40.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 3.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
KW   Repeat; WD repeat.
FT   CHAIN         1    342       Methylosome protein 50.
FT                                /FTId=PRO_0000051074.
FT   REPEAT       78    116       WD 1.
FT   REPEAT      123    162       WD 2.
FT   REPEAT      165    205       WD 3.
FT   REPEAT      209    250       WD 4.
FT   REPEAT      253    293       WD 5.
FT   CONFLICT    313    330       LTTVGWDHQVVHHVVPTE -> DLQVLLSRLDLRQKASPP
FT                                (in Ref. 2; AAH09411).
FT   CONFLICT    331    342       Missing (in Ref. 2; AAH09411).
SQ   SEQUENCE   342 AA;  36724 MW;  3D355AEC68491ECB CRC64;
     MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS GRCWAGSLWL
     FKDPCAAPNE GFCSAGVQTE AGVADLTWVG ERGILVASDS GAVELWELDE NETLIVSKFC
     KYEHDDIVST VSVLSSGTQA VSGSKDICIK VWDLAQQVVL SSYRAHAAQV TCVAASPHKD
     SVFLSCSEDN RILLWDTRCP KPASQIGCSA PGYLPTSLAW HPQQSEVFVF GDENGTVSLV
     DTKSTSCVLS SAVHSQCVTG LVFSPHSVPF LASLSEDCSL AVLDSSLSEL FRSQAHRDFV
     RDATWSPLNH SLLTTVGWDH QVVHHVVPTE PLPAPGPASV TE
//