ID   RETNB_HUMAN             Reviewed;         111 AA.
AC   Q9BQ08; Q14D27;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   12-AUG-2020, entry version 132.
DE   RecName: Full=Resistin-like beta;
DE   AltName: Full=Colon and small intestine-specific cysteine-rich protein;
DE   AltName: Full=Colon carcinoma-related gene protein;
DE   AltName: Full=Cysteine-rich secreted protein A12-alpha-like 1;
DE   AltName: Full=Cysteine-rich secreted protein FIZZ2;
DE   AltName: Full=RELMbeta;
DE   Flags: Precursor;
GN   Name=RETNLB; Synonyms=CCRG, FIZZ2, HXCP2, RETNL2; ORFNames=UNQ408/PRO770;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11090083;
RA   Kubota T., Kawano S., Chih D.Y., Hisatake Y., Chumakov A.M., Taguchi H.,
RA   Koeffler H.P.;
RT   "Representational difference analysis using myeloid cells from C/EBP
RT   epsilon deletional mice.";
RL   Blood 96:3953-3957(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11209052; DOI=10.1073/pnas.98.2.502;
RA   Steppan C.M., Brown E.J., Wright C.M., Bhat S., Banerjee R.R., Dai C.Y.,
RA   Enders G.H., Silberg D.G., Wen X., Wu G.D., Lazar M.A.;
RT   "A family of tissue-specific resistin-like molecules.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:502-506(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Rajala M.W., Scherer P.E.;
RT   "Identification of a novel cysteine-rich secreted A12-alpha related
RT   protein.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=12224133;
RA   De Young M.P., Damania H., Scheurle D., Zylberberg C., Narayanan R.;
RT   "Bioinformatics based discovery of a novel factor with apparent specificity
RT   to colon cancer.";
RL   In Vivo 16:239-248(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable hormone.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed only in the gastrointestinal tract,
CC       particularly the colon.
CC   -!- SIMILARITY: Belongs to the resistin/FIZZ family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF352731; AAK18622.1; -; Genomic_DNA.
DR   EMBL; AF323084; AAG59827.1; -; mRNA.
DR   EMBL; AF290873; AAK83105.1; -; mRNA.
DR   EMBL; AF323921; AAL96378.1; -; mRNA.
DR   EMBL; AY358655; AAQ89018.1; -; mRNA.
DR   EMBL; BC069318; AAH69318.1; -; mRNA.
DR   EMBL; BC113502; AAI13503.1; -; mRNA.
DR   EMBL; BC113528; AAI13529.1; -; mRNA.
DR   CCDS; CCDS2953.1; -.
DR   RefSeq; NP_115968.1; NM_032579.2.
DR   SMR; Q9BQ08; -.
DR   BioGRID; 124186; 20.
DR   STRING; 9606.ENSP00000295755; -.
DR   TCDB; 9.B.329.1.2; the resistin-like molecule (relm) family.
DR   BioMuta; RETNLB; -.
DR   DMDM; 18202730; -.
DR   PaxDb; Q9BQ08; -.
DR   PeptideAtlas; Q9BQ08; -.
DR   PRIDE; Q9BQ08; -.
DR   ProteomicsDB; 78607; -.
DR   Antibodypedia; 16152; 351 antibodies.
DR   DNASU; 84666; -.
DR   Ensembl; ENST00000295755; ENSP00000295755; ENSG00000163515.
DR   GeneID; 84666; -.
DR   KEGG; hsa:84666; -.
DR   UCSC; uc003dxh.3; human.
DR   CTD; 84666; -.
DR   DisGeNET; 84666; -.
DR   EuPathDB; HostDB:ENSG00000163515.6; -.
DR   GeneCards; RETNLB; -.
DR   HGNC; HGNC:20388; RETNLB.
DR   HPA; ENSG00000163515; Tissue enriched (intestine).
DR   MIM; 605645; gene.
DR   neXtProt; NX_Q9BQ08; -.
DR   OpenTargets; ENSG00000163515; -.
DR   PharmGKB; PA134906814; -.
DR   eggNOG; ENOG502RTZZ; Eukaryota.
DR   GeneTree; ENSGT00390000016177; -.
DR   HOGENOM; CLU_150117_0_0_1; -.
DR   InParanoid; Q9BQ08; -.
DR   KO; K13438; -.
DR   OMA; CQCSVVD; -.
DR   OrthoDB; 1541877at2759; -.
DR   PhylomeDB; Q9BQ08; -.
DR   TreeFam; TF337024; -.
DR   PathwayCommons; Q9BQ08; -.
DR   BioGRID-ORCS; 84666; 5 hits in 863 CRISPR screens.
DR   ChiTaRS; RETNLB; human.
DR   GeneWiki; RETNLB; -.
DR   GenomeRNAi; 84666; -.
DR   Pharos; Q9BQ08; Tbio.
DR   PRO; PR:Q9BQ08; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q9BQ08; protein.
DR   Bgee; ENSG00000163515; Expressed in rectum and 56 other tissues.
DR   Genevisible; Q9BQ08; HS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0050673; P:epithelial cell proliferation; IEP:UniProtKB.
DR   CDD; cd16333; RELM; 1.
DR   Gene3D; 3.30.1660.20; -; 1.
DR   InterPro; IPR009714; Resistin.
DR   InterPro; IPR036262; Resistin-like_sf.
DR   PANTHER; PTHR21101; PTHR21101; 1.
DR   Pfam; PF06954; Resistin; 1.
DR   SUPFAM; SSF111423; SSF111423; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Polymorphism; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..111
FT                   /note="Resistin-like beta"
FT                   /id="PRO_0000030345"
FT   DISULFID        25
FT                   /note="Interchain"
FT                   /evidence="ECO:0000305"
FT   DISULFID        55..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        67..107
FT                   /evidence="ECO:0000250"
FT   DISULFID        76..93
FT                   /evidence="ECO:0000250"
FT   DISULFID        78..95
FT                   /evidence="ECO:0000250"
FT   DISULFID        82..97
FT                   /evidence="ECO:0000250"
FT   VARIANT         20
FT                   /note="P -> L (in dbSNP:rs11708527)"
FT                   /id="VAR_051791"
SQ   SEQUENCE   111 AA;  11730 MW;  BD64233AF302B4C0 CRC64;
     MGPSSCLLLI LIPLLQLINP GSTQCSLDSV MDKKIKDVLN SLEYSPSPIS KKLSCASVKS
     QGRPSSCPAG MAVTGCACGY GCGSWDVQLE TTCHCQCSVV DWTTARCCHL T
//