ID TOR_SCHHA Reviewed; 313 AA. AC Q9BLM6; DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot. DT 21-SEP-2011, sequence version 2. DT 22-APR-2020, entry version 37. DE RecName: Full=Tetraspanning orphan receptor {ECO:0000250|UniProtKB:C4QM85}; DE AltName: Full=Complement C2 receptor inhibitor tetraspanning {ECO:0000250|UniProtKB:C4QM85}; DE AltName: Full=Complement C2 receptor inhibitor trispanning {ECO:0000303|PubMed:10734221}; DE AltName: Full=Trispanning orphan receptor {ECO:0000312|EMBL:AAK11492.1}; DE Short=Sh-TOR {ECO:0000303|PubMed:10366712, ECO:0000303|PubMed:10734221}; DE Flags: Fragment; GN Name=TOR {ECO:0000303|PubMed:10366712, ECO:0000303|PubMed:10734221}; GN Synonyms=TM3 {ECO:0000312|EMBL:AAK11492.1}; OS Schistosoma haematobium (Blood fluke). OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda; OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma. OX NCBI_TaxID=6185; RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK11492.1} RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL RP STAGE, AND PHOSPHORYLATION. RX PubMed=10366712; DOI=10.1016/s0167-4781(99)00051-2; RA Inal J.M.; RT "Schistosoma TOR (trispanning orphan receptor), a novel, antigenic surface RT receptor of the blood-dwelling, Schistosoma parasite."; RL Biochim. Biophys. Acta 1445:283-298(1999). RN [2] {ECO:0000305} RP FUNCTION, AND INTERACTION WITH HUMAN C2B. RX PubMed=10734221; DOI=10.1016/s0014-5793(00)01304-1; RA Inal J.M., Sim R.B.; RT "A Schistosoma protein, Sh-TOR, is a novel inhibitor of complement which RT binds human C2."; RL FEBS Lett. 470:131-134(2000). CC -!- FUNCTION: Cell surface receptor that binds to human complement C2a CC protein. This results in inhibition of the classical and lectin CC pathways of complement activation, probably due to interference with CC binding of C2a to C4b and interference with cleavage by C1 or MASP2 CC such that C3 convertase cannot be formed. This infers resistance to CC complement-mediated cell lysis, allowing parasite survival and CC infection. {ECO:0000250|UniProtKB:Q5J7P3, ECO:0000269|PubMed:10366712, CC ECO:0000269|PubMed:10734221}. CC -!- SUBUNIT: Interacts (via N-terminal extracellular domain) with human CC C2a. {ECO:0000269|PubMed:10734221}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10366712}; CC Multi-pass membrane protein {ECO:0000269|PubMed:10366712}. Note=Located CC on the surface tegumental plasma membrane, and tegumental surface pits CC of adult schistosomes so in contact with host blood plasma. CC {ECO:0000269|PubMed:10366712}. CC -!- DEVELOPMENTAL STAGE: Highly expressed in parasitic larvae (cercariae) CC and at a lower level in adults. {ECO:0000269|PubMed:10366712}. CC -!- PTM: Phosphorylated on tyrosine residues. CC {ECO:0000269|PubMed:10366712}. CC -!- MISCELLANEOUS: Specifically and strongly recognized by a serum from CC baboons vaccinated with irradiated parasite. Potential vaccine CC candidate molecule. {ECO:0000269|PubMed:10366712, CC ECO:0000303|PubMed:10366712}. CC -!- SEQUENCE CAUTION: CC Sequence=AAK11492.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U57714; AAK11492.1; ALT_INIT; mRNA. DR SMR; Q9BLM6; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. PE 1: Evidence at protein level; KW Cell membrane; Membrane; Phosphoprotein; Receptor; Transmembrane; KW Transmembrane helix. FT CHAIN <1..313 FT /note="Tetraspanning orphan receptor" FT /id="PRO_0000412758" FT TOPO_DOM <1..54 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 55..75 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 76..82 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 83..103 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 104..129 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 130..150 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 151..313 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT COMPBIAS 250..300 FT /note="Thr-rich" FT /evidence="ECO:0000255" FT NON_TER 1 FT /evidence="ECO:0000305" SQ SEQUENCE 313 AA; 34846 MW; 60DA5651B27BEF1B CRC64; PQCESETNFH YDIPPGYKDD VLVDVNNMSP SLVSDTQKHE RGSHEVKIKH FSPYIAVCVT TFSLAFCCFM VHAAITRQPT HLLPFFFIQV FDLIICLIHI LGFMSSTSDI RLVIHTKTGP IYIKSTGLTF IILSISCMML AFKAYCLGMV WDCYKYLMLN RRGNLLDDWY SDQWGHLSTF WSLLRTGRNR GNNSIGNSGS PNEPNTRPRP DTITYDPAND LPKYEDILKI RNAYAPPPYY CSNTNGNVNT TTTDAVTTNT TITSATTANA TTTITTNANT NTSTTTSVIS PLTTTNKDDT QINNASSNAH SSC //