ID TOR_SCHHA Reviewed; 313 AA. AC Q9BLM6; DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot. DT 21-SEP-2011, sequence version 2. DT 21-SEP-2011, entry version 21. DE RecName: Full=Tetraspanning orphan receptor; DE AltName: Full=Complement C2 receptor inhibitor tetraspanning; DE AltName: Full=Complement C2 receptor inhibitor trispanning; DE AltName: Full=Trispanning orphan receptor; DE Short=Sh-TOR; DE Flags: Fragment; GN Name=TOR; Synonyms=TM3; OS Schistosoma haematobium (Blood fluke). OC Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida; OC Schistosomatoidea; Schistosomatidae; Schistosoma. OX NCBI_TaxID=6185; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, RP DEVELOPMENTAL STAGE, AND PHOSPHORYLATION. RX MEDLINE=99296361; PubMed=10366712; DOI=10.1016/S0167-4781(99)00051-2; RA Inal J.M.; RT "Schistosoma TOR (trispanning orphan receptor), a novel, antigenic RT surface receptor of the blood-dwelling, Schistosoma parasite."; RL Biochim. Biophys. Acta 1445:283-298(1999). RN [2] RP FUNCTION, AND INTERACTION WITH HUMAN C2B. RX PubMed=10734221; RA Inal J.M., Sim R.B.; RT "A Schistosoma protein, Sh-TOR, is a novel inhibitor of complement RT which binds human C2."; RL FEBS Lett. 470:131-134(2000). CC -!- FUNCTION: Cell surface receptor that binds to human complement C2a CC protein. This results in inhibition of the classical and lectin CC pathways of complement activation, probably due to interference CC with binding of C2a to C4b and interference with cleavage by C1 or CC MASP2 such that C3 convertase cannot be formed. This infers CC resistance to complement-mediated cell lysis, allowing parasite CC survival and infection. CC -!- SUBUNIT: Interacts (via N-terminal extracellular domain) with CC human C2a. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC Note=Located on the surface tegumental plasma membrane, and CC tegumental surface pits of adult schistosomes so in contact with CC host blood plasma. CC -!- DEVELOPMENTAL STAGE: Highly expressed in parasitic larvae CC (cercariae) and at a lower level in adults. CC -!- PTM: Phosphorylated on tyrosine residues. CC -!- MISCELLANEOUS: Specifically and strongly recognized by a serum CC from baboons vaccinated with irradiated parasite. Potential CC vaccine candidate molecule. CC -!- SEQUENCE CAUTION: CC Sequence=AAK11492.1; Type=Erroneous initiation; Note=Translation N-terminally extended; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U57714; AAK11492.1; ALT_INIT; mRNA. DR GO; GO:0016021; C:integral to membrane; IEA:InterPro. DR GO; GO:0004872; F:receptor activity; IEA:UniProtKB-KW. DR InterPro; IPR004687; LAPTM4/5. DR PANTHER; PTHR12479; Mtp_transporter; 1. PE 1: Evidence at protein level; KW Cell membrane; Membrane; Phosphoprotein; Receptor; Transmembrane; KW Transmembrane helix. FT CHAIN <1 313 Tetraspanning orphan receptor. FT /FTId=PRO_0000412758. FT TOPO_DOM <1 54 Extracellular (Potential). FT TRANSMEM 55 75 Helical; (Potential). FT TOPO_DOM 76 82 Cytoplasmic (Potential). FT TRANSMEM 83 103 Helical; (Potential). FT TOPO_DOM 104 129 Extracellular (Potential). FT TRANSMEM 130 150 Helical; (Potential). FT TOPO_DOM 151 313 Cytoplasmic (Potential). FT COMPBIAS 250 300 Thr-rich. FT NON_TER 1 1 SQ SEQUENCE 313 AA; 34846 MW; 60DA5651B27BEF1B CRC64; PQCESETNFH YDIPPGYKDD VLVDVNNMSP SLVSDTQKHE RGSHEVKIKH FSPYIAVCVT TFSLAFCCFM VHAAITRQPT HLLPFFFIQV FDLIICLIHI LGFMSSTSDI RLVIHTKTGP IYIKSTGLTF IILSISCMML AFKAYCLGMV WDCYKYLMLN RRGNLLDDWY SDQWGHLSTF WSLLRTGRNR GNNSIGNSGS PNEPNTRPRP DTITYDPAND LPKYEDILKI RNAYAPPPYY CSNTNGNVNT TTTDAVTTNT TITSATTANA TTTITTNANT NTSTTTSVIS PLTTTNKDDT QINNASSNAH SSC //