ID Q9B2U8_HUMAN Unreviewed; 227 AA. AC Q9B2U8; DT 01-JUN-2001, integrated into UniProtKB/TrEMBL. DT 01-JUN-2001, sequence version 1. DT 16-APR-2014, entry version 98. DE RecName: Full=Cytochrome c oxidase subunit 2; GN Name=COX2; Synonyms=COII, coxII; OS Homo sapiens (Human). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX PubMed=11130070; DOI=10.1038/35047064; RA Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.; RT "Mitochondrial genome variation and the origin of modern humans."; RL Nature 408:708-713(2000). RN [2] RP NUCLEOTIDE SEQUENCE. RA Ingman M., Kaessmann H., Paabo S., Gyllensten U.; RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C22; RX PubMed=15467980; DOI=10.1086/425871; RA Palanichamy M.G., Sun C., Agrawal S., Bandelt H.-J., Kong Q.-P., RA Khan F., Wang C.Y., Chaudhuri T.K., Palla V., Zhang Y.-P.; RT "Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on RT complete sequencing: implications for the peopling of South Asia."; RL Am. J. Hum. Genet. 75:966-978(2004). RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=HNsq0191, KAsq0057, ONsq0136, and PDsq0032; RX PubMed=15466285; DOI=10.1101/gr.2286304; RA Tanaka M., Cabrera V.M., Gonzalez A.M., Larruga J.M., Takeyasu T., RA Fuku N., Guo L., Hirose R., Fujita Y., Kurata M., Shinoda K., RA Umetsu K., Yamada Y., Oshida Y., Sato Y., Hattori N., Mizuno Y., RA Arai Y., Hirose N., Ohta S., Ogawa O., Tanaka Y., Kawamori R., RA Shamoto-Nagai M., Maruyama W., Shimokata H., Suzuki R., Shimodaira H.; RT "Mitochondrial genome variation in eastern Asia and the peopling of RT Japan."; RL Genome Res. 14:1832-1850(2004). RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=ONsq0136; RA Guo L., Oshida Y., Fuku N., Takeyasu T., Fujita Y., Kurata M., RA Sato Y., Ito M., Tanaka M.; RT "Mitochondrial genome polymorphisms associated with type-2 diabetes or RT obesity."; RL Mitochondrion 0:0-0(2004). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=IND8; RX PubMed=15804362; DOI=10.1186/1471-2148-5-26; RA Rajkumar R., Banerjee J., Gunturi H.B., Trivedi R., Kashyap V.K.; RT "Phylogeny and antiquity of M macrohaplogroup inferred from complete RT mt DNA sequence of Indian specific lineages."; RL BMC Evol. Biol. 5:26-26(2005). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd4; RX PubMed=16048457; DOI=10.1111/j.1440-1819.2005.01404.x; RA Kazuno A., Munakata K., Mori K., Tanaka M., Nanko S., Kunugi H., RA Umekage T., Tochigi M., Kohda K., Sasaki T., Akiyama T., Washizuka S., RA Kato N., Kato T.; RT "Mitochondrial DNA sequence analysis of patients with 'atypical RT psychosis'."; RL Psychiatry Clin. Neurosci. 59:497-503(2005). RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=HNsq0191, KAsq0057, ONsq0136, and PDsq0032; RA Tanaka M.; RT "Human mitochondrial genome polymorphism database (mtSNP)."; RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE. RC STRAIN=AS74; RX PubMed=16172508; DOI=10.1534/genetics.105.043901; RA Kivisild T., Shen P., Wall D.P., Do B., Sung R., Davis K.K., RA Passarino G., Underhill P.A., Scharfe C., Torroni A., Scozzari R., RA Modiano D., Coppa A., de Knjiff P., Feldman M.W., Cavalli-Sforza L.L., RA Oefner P.J.; RT "The role of selection in the evolution of human mitochondrial RT genomes."; RL Genetics 172:373-387(2006). RN [10] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd4; RX PubMed=16895436; DOI=10.1371/journal.pgen.0020128; RA Kazuno A., Munakata K., Nagai T., Shimozono S., Tanaka M., Yoneda M., RA Kato N., Miyawaki A., Kato T.; RT "Identification of mitochondrial DNA polymorphisms that alter RT mitochondrial matrix pH and intracellular calcium dynamics."; RL PLoS Genet. 2:e128-e128(2006). RN [11] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd4; RA Kazuno A., Munakata K., Mori K., Nanko S., Kunugi H., Nakamura K., RA Mori N., Yamada K., Yoshikawa T., Kato N., Kato T.; RT "Mitochondrial DNA haplogroup analysis in patients with Bipolar RT Disorder."; RL Am. J. Med. Genet. B Neuropsychiatr. Genet. 0:0-0(2008). RN [12] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd4; RX PubMed=17288645; RA Kazuno A., Munakata K., Kato N., Kato T.; RT "Mitochondrial DNA-dependent effects of valproate on mitochondrial RT calcium levels in transmitochondrial cybrids."; RL Int. J. Neuropsychopharmacol. 11:71-78(2008). RN [13] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mdmd4; RX PubMed=18226984; DOI=10.1016/j.mito.2007.12.002; RA Kazuno A., Munakata K., Tanaka M., Kato N., Kato T.; RT "Relationships between mitochondrial DNA subhaplogroups and RT intracellular calcium dynamics."; RL Mitochondrion 8:164-169(2008). RN [14] RP NUCLEOTIDE SEQUENCE. RC STRAIN=SL003; RX PubMed=18359946; DOI=10.1093/molbev/msn068; RA Soares P., Trejaut J.A., Loo J.H., Hill C., Mormina M., Lee C.L., RA Chen Y.M., Hudjashov G., Forster P., Macaulay V., Bulbeck D., RA Oppenheimer S., Lin M., Richards M.B.; RT "Climate change and postglacial human dispersals in southeast Asia."; RL Mol. Biol. Evol. 25:1209-1218(2008). RN [15] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Fuj5202B; RA Trejaut J.A., Loo J.H., Lin M.; RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases. RN [16] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Fuj5202B; RX PubMed=19755666; DOI=10.1093/molbev/msp215; RA Tabbada K.A., Trejaut J., Loo J.H., Chen Y.M., Lin M., RA Mirazon-Lahr M., Kivisild T., De Ungria M.C.; RT "Philippine mitochondrial DNA diversity: a populated viaduct between RT Taiwan and Indonesia?"; RL Mol. Biol. Evol. 27:21-31(2010). RN [17] RP NUCLEOTIDE SEQUENCE. RX PubMed=22482806; DOI=10.1016/j.ajhg.2012.03.002; RA Behar D.M., van Oven M., Rosset S., Metspalu M., Loogvali E.L., RA Silva N.M., Kivisild T., Torroni A., Villems R.; RT "A "Copernican" reassessment of the human mitochondrial DNA tree from RT its root."; RL Am. J. Hum. Genet. 90:675-684(2012). RN [18] RP NUCLEOTIDE SEQUENCE. RX PubMed=22560092; DOI=10.1016/j.ajhg.2012.04.003; RA Pala M., Olivieri A., Achilli A., Accetturo M., Metspalu E., RA Reidla M., Tamm E., Karmin M., Reisberg T., Hooshiar Kashani B., RA Perego U.A., Carossa V., Gandini F., Pereira J.B., Soares P., RA Angerhofer N., Rychkov S., Al-Zahery N., Carelli V., Sanati M.H., RA Houshmand M., Hatina J., Macaulay V., Pereira L., Woodward S.R., RA Davies W., Gamble C., Baird D., Semino O., Villems R., Torroni A., RA Richards M.B.; RT "Mitochondrial DNA signals of late glacial recolonization of europe RT from near eastern refugia."; RL Am. J. Hum. Genet. 90:915-924(2012). RN [19] RP NUCLEOTIDE SEQUENCE. RX PubMed=22096215; DOI=10.1093/molbev/msr245; RA Soares P., Alshamali F., Pereira J.B., Fernandes V., Silva N.M., RA Afonso C., Costa M.D., Musilova E., Macaulay V., Richards M.B., RA Cerny V., Pereira L.; RT "The Expansion of mtDNA Haplogroup L3 within and out of Africa."; RL Mol. Biol. Evol. 29:915-927(2012). RN [20] RP NUCLEOTIDE SEQUENCE. RX PubMed=23332919; DOI=10.1016/j.ajhg.2012.12.010; RA Barbieri C., Vicente M., Rocha J., Mpoloka S.W., Stoneking M., RA Pakendorf B.; RT "Ancient substructure in early mtDNA lineages of southern Africa."; RL Am. J. Hum. Genet. 92:285-292(2013). RN [21] RP NUCLEOTIDE SEQUENCE. RX PubMed=24006865; RA Fang Y., Huang J., Zhang J., Wang J., Qiao F., Chen H.M., Hong Z.P.; RT "Detecting the somatic mutations spectrum of Chinese lung cancer by RT analyzing the whole mitochondrial DNA genomes."; RL Mitochondrial DNA 0:0-0(2013). RN [22] RP NUCLEOTIDE SEQUENCE. RA Mikami E., Fuku N., Kong Q.P., Takahashi H., Ohiwa N., Murakami H., RA Miyachi M., Pitsiladis Y.P., Higuchi M., Kawahara T., Tanaka M.; RT "Comprehensive analysis of common and rare mitochondrial DNA variants RT in elite Japanese athletes: Case-control study."; RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. Subunit 2 CC transfers the electrons from cytochrome c via its binuclear copper CC A center to the bimetallic center of the catalytic subunit 1 (By CC similarity). CC -!- COFACTOR: Copper A (By similarity). CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF347008; AAK17795.1; -; Genomic_DNA. DR EMBL; AY714004; AAU02491.1; -; Genomic_DNA. DR EMBL; DQ112879; AAZ02298.1; -; Genomic_DNA. DR EMBL; DQ246818; ABB45497.1; -; Genomic_DNA. DR EMBL; EF093554; ABL61830.1; -; Genomic_DNA. DR EMBL; GQ119008; ACS48574.1; -; Genomic_DNA. DR EMBL; JN655781; AEQ26493.1; -; Genomic_DNA. DR EMBL; JQ702268; AFF67445.1; -; Genomic_DNA. DR EMBL; JQ798080; AFI53791.1; -; Genomic_DNA. DR EMBL; KC346162; AGD87064.1; -; Genomic_DNA. DR EMBL; KC733262; AGL11513.1; -; Genomic_DNA. DR EMBL; KC733263; AGL11526.2; -; Genomic_DNA. DR EMBL; KC733264; AGL11539.1; -; Genomic_DNA. DR EMBL; AP008370; BAE08796.1; -; Genomic_DNA. DR EMBL; AP008495; BAE10421.1; -; Genomic_DNA. DR EMBL; AP008623; BAE12087.1; -; Genomic_DNA. DR EMBL; AP008678; BAE12802.1; -; Genomic_DNA. DR EMBL; AP009422; BAG38749.1; -; Genomic_DNA. DR EMBL; AP013218; BAN80673.1; -; Genomic_DNA. DR ProteinModelPortal; Q9B2U8; -. DR SMR; Q9B2U8; 1-220. DR PRIDE; Q9B2U8; -. DR KEGG; hsa:4513; -. DR CTD; 4513; -. DR HOVERGEN; HBG012727; -. DR NextBio; 35541639; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0005507; F:copper ion binding; IEA:InterPro. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro. DR GO; GO:0022900; P:electron transport chain; IEA:InterPro. DR Gene3D; 1.10.287.90; -; 1. DR Gene3D; 2.60.40.420; -; 1. DR InterPro; IPR001505; Copper_CuA. DR InterPro; IPR008972; Cupredoxin. DR InterPro; IPR014222; Cyt_c_oxidase_su2. DR InterPro; IPR002429; Cyt_c_oxidase_su2_C. DR InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom. DR Pfam; PF00116; COX2; 1. DR Pfam; PF02790; COX2_TM; 1. DR SUPFAM; SSF49503; SSF49503; 1. DR SUPFAM; SSF81464; SSF81464; 1. DR TIGRFAMs; TIGR02866; CoxB; 1. DR PROSITE; PS00078; COX2; 1. DR PROSITE; PS50857; COX2_CUA; 1. DR PROSITE; PS50999; COX2_TM; 1. PE 3: Inferred from homology; KW Copper; Electron transport; Membrane; Metal-binding; Mitochondrion; KW Mitochondrion inner membrane; Respiratory chain; Transmembrane; KW Transmembrane helix; Transport. SQ SEQUENCE 227 AA; 25551 MW; 799836363CB4FF7C CRC64; MAHAAQVGLQ DATSPIMEEL ITFHDHALMV IFLICFLVLY ALFLTLTTKL TNTNISDAQE METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL //