ID   Q9B2U8_HUMAN            Unreviewed;       227 AA.
AC   Q9B2U8;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   18-APR-2012, entry version 77.
DE   RecName: Full=Cytochrome c oxidase subunit 2;
GN   Name=COII; Synonyms=COX2;
OS   Homo sapiens (Human).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=21012010; PubMed=11130070; DOI=10.1038/35047064;
RA   Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.;
RT   "Mitochondrial genome variation and the origin of modern humans.";
RL   Nature 408:708-713(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Ingman M., Kaessmann H., Paabo S., Gyllensten U.;
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C22;
RX   PubMed=15467980; DOI=10.1086/425871;
RA   Palanichamy M.G., Sun C., Agrawal S., Bandelt H.-J., Kong Q.-P.,
RA   Khan F., Wang C.Y., Chaudhuri T.K., Palla V., Zhang Y.-P.;
RT   "Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on
RT   complete sequencing: implications for the peopling of South Asia.";
RL   Am. J. Hum. Genet. 75:966-978(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HNsq0191, KAsq0057, ONsq0136, and PDsq0032;
RX   PubMed=15466285; DOI=10.1101/gr.2286304;
RA   Tanaka M., Cabrera V.M., Gonzalez A.M., Larruga J.M., Takeyasu T.,
RA   Fuku N., Guo L., Hirose R., Fujita Y., Kurata M., Shinoda K.,
RA   Umetsu K., Yamada Y., Oshida Y., Sato Y., Hattori N., Mizuno Y.,
RA   Arai Y., Hirose N., Ohta S., Ogawa O., Tanaka Y., Kawamori R.,
RA   Shamoto-Nagai M., Maruyama W., Shimokata H., Suzuki R., Shimodaira H.;
RT   "Mitochondrial genome variation in eastern Asia and the peopling of
RT   Japan.";
RL   Genome Res. 14:1832-1850(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ONsq0136;
RA   Guo L., Oshida Y., Fuku N., Takeyasu T., Fujita Y., Kurata M.,
RA   Sato Y., Ito M., Tanaka M.;
RT   "Mitochondrial genome polymorphisms associated with type-2 diabetes or
RT   obesity.";
RL   Mitochondrion 0:0-0(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=IND8;
RX   PubMed=15804362; DOI=10.1186/1471-2148-5-26;
RA   Rajkumar R., Banerjee J., Gunturi H.B., Trivedi R., Kashyap V.K.;
RT   "Phylogeny and antiquity of M macrohaplogroup inferred from complete
RT   mt DNA sequence of Indian specific lineages.";
RL   BMC Evol. Biol. 5:26-26(2005).
RN   [7]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4;
RX   PubMed=16048457; DOI=10.1111/j.1440-1819.2005.01404.x;
RA   Kazuno A., Munakata K., Mori K., Tanaka M., Nanko S., Kunugi H.,
RA   Umekage T., Tochigi M., Kohda K., Sasaki T., Akiyama T., Washizuka S.,
RA   Kato N., Kato T.;
RT   "Mitochondrial DNA sequence analysis of patients with 'atypical
RT   psychosis'.";
RL   Psychiatry Clin. Neurosci. 59:497-503(2005).
RN   [8]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HNsq0191, KAsq0057, ONsq0136, and PDsq0032;
RA   Tanaka M.;
RT   "Human mitochondrial genome polymorphism database (mtSNP).";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AS74;
RX   PubMed=16172508; DOI=10.1534/genetics.105.043901;
RA   Kivisild T., Shen P., Wall D.P., Do B., Sung R., Davis K.K.,
RA   Passarino G., Underhill P.A., Scharfe C., Torroni A., Scozzari R.,
RA   Modiano D., Coppa A., de Knjiff P., Feldman M.W., Cavalli-Sforza L.L.,
RA   Oefner P.J.;
RT   "The role of selection in the evolution of human mitochondrial
RT   genomes.";
RL   Genetics 172:373-387(2006).
RN   [10]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4;
RX   PubMed=16895436; DOI=10.1371/journal.pgen.0020128;
RA   Kazuno A., Munakata K., Nagai T., Shimozono S., Tanaka M., Yoneda M.,
RA   Kato N., Miyawaki A., Kato T.;
RT   "Identification of mitochondrial DNA polymorphisms that alter
RT   mitochondrial matrix pH and intracellular calcium dynamics.";
RL   PLoS Genet. 2:e128-e128(2006).
RN   [11]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4;
RA   Kazuno A., Munakata K., Mori K., Nanko S., Kunugi H., Nakamura K.,
RA   Mori N., Yamada K., Yoshikawa T., Kato N., Kato T.;
RT   "Mitochondrial DNA haplogroup analysis in patients with Bipolar
RT   Disorder.";
RL   Am. J. Med. Genet. B Neuropsychiatr. Genet. 0:0-0(2008).
RN   [12]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4;
RX   PubMed=17288645;
RA   Kazuno A., Munakata K., Kato N., Kato T.;
RT   "Mitochondrial DNA-dependent effects of valproate on mitochondrial
RT   calcium levels in transmitochondrial cybrids.";
RL   Int. J. Neuropsychopharmacol. 11:71-78(2008).
RN   [13]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4;
RX   PubMed=18226984; DOI=10.1016/j.mito.2007.12.002;
RA   Kazuno A., Munakata K., Tanaka M., Kato N., Kato T.;
RT   "Relationships between mitochondrial DNA subhaplogroups and
RT   intracellular calcium dynamics.";
RL   Mitochondrion 8:164-169(2008).
RN   [14]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SL003;
RX   PubMed=18359946; DOI=10.1093/molbev/msn068;
RA   Soares P., Trejaut J.A., Loo J.H., Hill C., Mormina M., Lee C.L.,
RA   Chen Y.M., Hudjashov G., Forster P., Macaulay V., Bulbeck D.,
RA   Oppenheimer S., Lin M., Richards M.B.;
RT   "Climate change and postglacial human dispersals in southeast Asia.";
RL   Mol. Biol. Evol. 25:1209-1218(2008).
RN   [15]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Fuj5202B;
RA   Trejaut J.A., Loo J.H., Lin M.;
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN   [16]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Fuj5202B;
RX   PubMed=19755666; DOI=10.1093/molbev/msp215;
RA   Tabbada K.A., Trejaut J., Loo J.H., Chen Y.M., Lin M.,
RA   Mirazon-Lahr M., Kivisild T., De Ungria M.C.;
RT   "Philippine mitochondrial DNA diversity: a populated viaduct between
RT   Taiwan and Indonesia?";
RL   Mol. Biol. Evol. 27:21-31(2010).
RN   [17]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22096215; DOI=10.1093/molbev/msr245;
RA   Soares P., Alshamali F., Pereira J.B., Fernandes V., Silva N.M.,
RA   Afonso C., Costa M.D., Musilova E., Macaulay V., Richards M.B.,
RA   Cerny V., Pereira L.;
RT   "The Expansion of mtDNA Haplogroup L3 within and out of Africa.";
RL   Mol. Biol. Evol. 29:915-927(2012).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. Subunit 2
CC       transfers the electrons from cytochrome c via its binuclear copper
CC       A center to the bimetallic center of the catalytic subunit 1 (By
CC       similarity).
CC   -!- COFACTOR: Copper A (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
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DR   EMBL; AF347008; AAK17795.1; -; Genomic_DNA.
DR   EMBL; AY714004; AAU02491.1; -; Genomic_DNA.
DR   EMBL; DQ112879; AAZ02298.1; -; Genomic_DNA.
DR   EMBL; DQ246818; ABB45497.1; -; Genomic_DNA.
DR   EMBL; EF093554; ABL61830.1; -; Genomic_DNA.
DR   EMBL; GQ119008; ACS48574.1; -; Genomic_DNA.
DR   EMBL; JN655781; AEQ26493.1; -; Genomic_DNA.
DR   EMBL; AP008370; BAE08796.1; -; Genomic_DNA.
DR   EMBL; AP008495; BAE10421.1; -; Genomic_DNA.
DR   EMBL; AP008623; BAE12087.1; -; Genomic_DNA.
DR   EMBL; AP008678; BAE12802.1; -; Genomic_DNA.
DR   EMBL; AP009422; BAG38749.1; -; Genomic_DNA.
DR   IPI; IPI00017510; -.
DR   HSSP; P18400; 1CYX.
DR   ProteinModelPortal; Q9B2U8; -.
DR   SMR; Q9B2U8; 1-220.
DR   STRING; Q9B2U8; -.
DR   PRIDE; Q9B2U8; -.
DR   HOVERGEN; HBG012727; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0022904; P:respiratory electron transport chain; IEA:InterPro.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR014222; Cyt_c_oxidase_su2.
DR   InterPro; IPR015964; Cyt_c_oxidase_su2-like_TM_dom.
DR   InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR   InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR   Gene3D; G3DSA:1.10.287.90; COX2_TM; 1.
DR   Gene3D; G3DSA:2.60.40.420; Cupredoxin; 1.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   PRINTS; PR01166; CYCOXIDASEII.
DR   SUPFAM; SSF49503; Cupredoxin; 1.
DR   SUPFAM; SSF81464; Cyt_c_oxidase_II-like_TM; 1.
DR   TIGRFAMs; TIGR02866; CoxB; 1.
DR   PROSITE; PS00078; COX2; 1.
DR   PROSITE; PS50857; COX2_CUA; 1.
DR   PROSITE; PS50999; COX2_TM; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Respiratory chain; Transmembrane;
KW   Transmembrane helix; Transport.
SQ   SEQUENCE   227 AA;  25551 MW;  799836363CB4FF7C CRC64;
     MAHAAQVGLQ DATSPIMEEL ITFHDHALMV IFLICFLVLY ALFLTLTTKL TNTNISDAQE
     METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS
     YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN
     QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL
//