ID Q9B2U8 PRELIMINARY; PRT; 227 AA. AC Q9B2U8; DT 01-JUN-2001 (TrEMBLrel. 17, Created) DT 01-JUN-2001 (TrEMBLrel. 17, Last sequence update) DT 01-MAR-2002 (TrEMBLrel. 20, Last annotation update) DE CYTOCHROME C OXIDASE POLYPEPTIDE II (EC 1.9.3.1). OS Homo sapiens (Human). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=21012010; PubMed=11130070; RA Ingman M., Kaessmann H., Paabo S., Gyllensten U.; RT "Mitochondrial genome variation and the origin of modern humans."; RL Nature 408:708-713(2000). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=21176314; PubMed=11279504; RA Ingman M., Kaessmann H., Paabo S., Gyllensten U.; RT "correction: Mitochondrial genome variation and the origin of modern RT humans."; RL Nature 410:611-611(2001). RN [3] RP SEQUENCE FROM N.A. RA Ingman M., Kaessmann H., Paabo S., Gyllensten U.; RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: CYTOCHROME C OXIDASE IS THE COMPONENT OF THE RESPIRATORY CC CHAIN THAT CATALYZES THE REDUCTION OF OXYGEN TO WATER. SUBUNITS 1- CC 3 FORM THE FUNCTIONAL CORE OF THE ENZYME COMPLEX. SUBUNIT 2 CC TRANSFERS THE ELECTRONS FROM CYTOCHROME C VIA ITS BINUCLEAR COPPER CC A CENTER TO THE BIMETALLIC CENTER OF THE CATALYTIC SUBUNIT 1 (BY CC SIMILARITY). CC -!- CATALYTIC ACTIVITY: 4 FERROCYTOCHROME C + O(2) = 4 FERRICYTOCHROME CC C + 2 H(2)O. CC -!- COFACTOR: COPPER A AND HEME GROUP (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. MITOCHONDRIAL CC INNER MEMBRANE (BY SIMILARITY). CC -!- SIMILARITY: BELONGS TO THE CYTOCHROME C OXIDASE SUBUNIT 2 FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF347008; AAK17795.1; -. DR HSSP; P18400; 1CYX. DR InterPro; IPR001505; Copper_CuA. DR InterPro; IPR002429; Cyt_c_ox_2. DR Pfam; PF00116; COX2; 1. DR Pfam; PF02790; COX2_TM; 1. DR PRINTS; PR01166; CYCOXIDASEII. DR ProDom; PD000131; COX2; 1. DR PROSITE; PS00078; COX2; 1. KW Copper; Inner membrane; Mitochondrion; Oxidoreductase; KW Respiratory chain; Transmembrane. SQ SEQUENCE 227 AA; 25551 MW; 799836363CB4FF7C CRC64; MAHAAQVGLQ DATSPIMEEL ITFHDHALMV IFLICFLVLY ALFLTLTTKL TNTNISDAQE METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL //