ID   Q9B2U8_HUMAN            Unreviewed;       227 AA.
AC   Q9B2U8;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   26-JUN-2007, entry version 38.
DE   Cytochrome c oxidase subunit II (Cytochrome oxydase subunit II).
GN   Name=COX2; Synonyms=COII;
OS   Homo sapiens (Human).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=21012010; PubMed=11130070; DOI=10.1038/35047064;
RA   Ingman M., Kaessmann H., Paabo S., Gyllensten U.;
RT   "Mitochondrial genome variation and the origin of modern humans.";
RL   Nature 408:708-713(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Ingman M., Kaessmann H., Paabo S., Gyllensten U.;
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SL003;
RA   Trejaut J.A., Loo J.-H., Lin M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=IND8;
RA   Rajkumar R., Banerjee J., Gunturi H.B., Trivedi R., Kashyap V.K.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AS74;
RX   PubMed=16172508; DOI=10.1534/genetics.105.043901;
RA   Kivisild T., Shen P., Wall D.P., Do B., Sung R., Davis K.,
RA   Passarino G., Underhill P.A., Scharfe C., Torroni A., Scozzari R.,
RA   Modiano D., Coppa A., de Knijff P., Feldman M., Cavalli-Sforza L.L.,
RA   Oefner P.J.;
RT   "The role of selection in the evolution of human mitochondrial
RT   genomes.";
RL   Genetics 172:373-387(2006).
RN   [6]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HNsq0191, ONsq0136, KAsq0057, and PDsq0032;
RX   PubMed=15466285; DOI=10.1101/gr.2286304;
RA   Tanaka M., Cabrera V.M., Gonzalez A.M., Larruga J.M., Takeyasu T.,
RA   Fuku N., Guo L.J., Hirose R., Fujita Y., Kurata M., Shinoda K.,
RA   Umetsu K., Yamada Y., Oshida Y., Sato Y., Hattori N., Mizuno Y.,
RA   Arai Y., Hirose N., Ohta S., Ogawa O., Tanaka Y., Kawamori R.,
RA   Shamoto-Nagai M., Maruyama W., Shimokata H., Suzuki R., Shimodaira H.;
RT   "Mitochondrial genome variation in eastern Asia and the peopling of
RT   Japan.";
RL   Genome Res. 14:1832-1850(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HNsq0191, ONsq0136, KAsq0057, and PDsq0032;
RA   Tanaka M.;
RT   "Human mitochondrial genome polymorphism database (mtSNP).";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ONsq0136;
RA   Guo L., Oshida Y., Fuku N., Takeyasu T., Fujita Y., Kurata M.,
RA   Sato Y., Ito M., Tanaka M.;
RT   "Mitochondrial genome polymorphisms associated with type-2 diabetes or
RT   obesity.";
RL   Mitochondrion 0:0-0(2004).
RN   [9]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C22;
RX   PubMed=15467980; DOI=10.1086/425871;
RA   Palanichamy M.G., Sun C., Agrawal S., Bandelt H.-J., Kong Q.-P.,
RA   Khan F., Wang C.Y., Chaudhuri T.K., Palla V., Zhang Y.-P.;
RT   "Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on
RT   complete sequencing: implications for the peopling of South Asia.";
RL   Am. J. Hum. Genet. 75:966-978(2004).
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DR   EMBL; AF347008; AAK17795.1; -; Genomic_DNA.
DR   EMBL; AY714004; AAU02491.1; -; Genomic_DNA.
DR   EMBL; DQ112879; AAZ02298.1; -; Genomic_DNA.
DR   EMBL; DQ246818; ABB45497.1; -; Genomic_DNA.
DR   EMBL; EF093554; ABL61830.1; -; Genomic_DNA.
DR   EMBL; AP008370; BAE08796.1; -; Genomic_DNA.
DR   EMBL; AP008495; BAE10421.1; -; Genomic_DNA.
DR   EMBL; AP008623; BAE12087.1; -; Genomic_DNA.
DR   EMBL; AP008678; BAE12802.1; -; Genomic_DNA.
DR   HSSP; P18400; 1CYX.
DR   SMR; Q9B2U8; 2-220.
DR   Ensembl; ENSG00000198712; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0006118; P:electron transport; IEA:InterPro.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR014222; COX2.
DR   InterPro; IPR002429; COX2_C.
DR   InterPro; IPR011759; COX2_TM.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   PRINTS; PR01166; CYCOXIDASEII.
DR   ProDom; PD000131; Copper_CuA; 1.
DR   TIGRFAMs; TIGR02866; CoxB; 1.
DR   PROSITE; PS00078; COX2; 1.
DR   PROSITE; PS50857; COX2_CUA; 1.
DR   PROSITE; PS50999; COX2_TM; 1.
KW   Mitochondrion.
SQ   SEQUENCE   227 AA;  25551 MW;  799836363CB4FF7C CRC64;
     MAHAAQVGLQ DATSPIMEEL ITFHDHALMV IFLICFLVLY ALFLTLTTKL TNTNISDAQE
     METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS
     YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN
     QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL
//