ID Q9B2U8_HUMAN Unreviewed; 227 AA. AC Q9B2U8; DT 01-JUN-2001, integrated into UniProtKB/TrEMBL. DT 01-JUN-2001, sequence version 1. DT 01-MAY-2007, entry version 35. DE Cytochrome c oxidase subunit II (Cytochrome oxydase subunit II). GN Name=COX2; Synonyms=COII; OS Homo sapiens (Human). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=21012010; PubMed=11130070; DOI=10.1038/35047064; RA Ingman M., Kaessmann H., Paabo S., Gyllensten U.; RT "Mitochondrial genome variation and the origin of modern humans."; RL Nature 408:708-713(2000). RN [2] RP NUCLEOTIDE SEQUENCE. RA Ingman M., Kaessmann H., Paabo S., Gyllensten U.; RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=SL003; RA Trejaut J.A., Loo J.-H., Lin M.; RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=IND8; RA Rajkumar R., Banerjee J., Gunturi H.B., Trivedi R., Kashyap V.K.; RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=AS74; RX PubMed=16172508; DOI=10.1534/genetics.105.043901; RA Kivisild T., Shen P., Wall D.P., Do B., Sung R., Davis K., RA Passarino G., Underhill P.A., Scharfe C., Torroni A., Scozzari R., RA Modiano D., Coppa A., de Knijff P., Feldman M., Cavalli-Sforza L.L., RA Oefner P.J.; RT "The role of selection in the evolution of human mitochondrial RT genomes."; RL Genetics 172:373-387(2006). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=HNsq0191, ONsq0136, KAsq0057, and PDsq0032; RX PubMed=15466285; DOI=10.1101/gr.2286304; RA Tanaka M., Cabrera V.M., Gonzalez A.M., Larruga J.M., Takeyasu T., RA Fuku N., Guo L.J., Hirose R., Fujita Y., Kurata M., Shinoda K., RA Umetsu K., Yamada Y., Oshida Y., Sato Y., Hattori N., Mizuno Y., RA Arai Y., Hirose N., Ohta S., Ogawa O., Tanaka Y., Kawamori R., RA Shamoto-Nagai M., Maruyama W., Shimokata H., Suzuki R., Shimodaira H.; RT "Mitochondrial genome variation in eastern Asia and the peopling of RT Japan."; RL Genome Res. 14:1832-1850(2004). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=HNsq0191, ONsq0136, KAsq0057, and PDsq0032; RA Tanaka M.; RT "Human mitochondrial genome polymorphism database (mtSNP)."; RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=ONsq0136; RA Guo L., Oshida Y., Fuku N., Takeyasu T., Fujita Y., Kurata M., RA Sato Y., Ito M., Tanaka M.; RT "Mitochondrial genome polymorphisms associated with type-2 diabetes or RT obesity."; RL Mitochondrion 0:0-0(2004). RN [9] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C22; RX PubMed=15467980; DOI=10.1086/425871; RA Palanichamy M.G., Sun C., Agrawal S., Bandelt H.-J., Kong Q.-P., RA Khan F., Wang C.Y., Chaudhuri T.K., Palla V., Zhang Y.-P.; RT "Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on RT complete sequencing: implications for the peopling of South Asia."; RL Am. J. Hum. Genet. 75:966-978(2004). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF347008; AAK17795.1; -; Genomic_DNA. DR EMBL; EF093554; ABL61830.1; -; Genomic_DNA. DR EMBL; DQ112879; AAZ02298.1; -; Genomic_DNA. DR EMBL; DQ246818; ABB45497.1; -; Genomic_DNA. DR EMBL; AP008495; BAE10421.1; -; Genomic_DNA. DR EMBL; AY714004; AAU02491.1; -; Genomic_DNA. DR EMBL; AP008370; BAE08796.1; -; Genomic_DNA. DR EMBL; AP008623; BAE12087.1; -; Genomic_DNA. DR EMBL; AP008678; BAE12802.1; -; Genomic_DNA. DR HSSP; P18400; 1CYX. DR SMR; Q9B2U8; 2-220. DR Ensembl; ENSG00000198712; Homo sapiens. DR GO; GO:0016021; C:integral to membrane; IEA:InterPro. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0005507; F:copper ion binding; IEA:InterPro. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro. DR GO; GO:0006118; P:electron transport; IEA:InterPro. DR InterPro; IPR001505; Copper_CuA. DR InterPro; IPR002429; COX2_C. DR InterPro; IPR011759; COX2_TM. DR InterPro; IPR008972; Cupredoxin. DR Pfam; PF00116; COX2; 1. DR Pfam; PF02790; COX2_TM; 1. DR PRINTS; PR01166; CYCOXIDASEII. DR ProDom; PD000131; Copper_CuA; 1. DR PROSITE; PS00078; COX2; 1. DR PROSITE; PS50857; COX2_CUA; 1. DR PROSITE; PS50999; COX2_TM; 1. KW Mitochondrion. SQ SEQUENCE 227 AA; 25551 MW; 799836363CB4FF7C CRC64; MAHAAQVGLQ DATSPIMEEL ITFHDHALMV IFLICFLVLY ALFLTLTTKL TNTNISDAQE METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL //