ID   Q9B2U8_HUMAN            Unreviewed;       227 AA.
AC   Q9B2U8;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   29-MAY-2024, entry version 159.
DE   RecName: Full=Cytochrome c oxidase subunit 2 {ECO:0000256|ARBA:ARBA00015946, ECO:0000256|RuleBase:RU000457};
GN   Name=COX2 {ECO:0000313|EMBL:AAU02491.1};
GN   Synonyms=COII {ECO:0000313|EMBL:BAE08796.1}, coxII
GN   {ECO:0000313|EMBL:BAN80673.1};
OS   Homo sapiens (Human).
OG   Mitochondrion {ECO:0000313|EMBL:AAK17795.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAK17795.1};
RN   [1] {ECO:0000313|EMBL:AAK17795.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11130070; DOI=10.1038/35047064;
RA   Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.;
RT   "Mitochondrial genome variation and the origin of modern humans.";
RL   Nature 408:708-713(2000).
RN   [2] {ECO:0000313|EMBL:AAK17795.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Ingman M., Kaessmann H., Paabo S., Gyllensten U.;
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAU02491.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C22 {ECO:0000313|EMBL:AAU02491.1};
RX   PubMed=15467980; DOI=10.1086/425871;
RA   Palanichamy M.G., Sun C., Agrawal S., Bandelt H.-J., Kong Q.-P., Khan F.,
RA   Wang C.Y., Chaudhuri T.K., Palla V., Zhang Y.-P.;
RT   "Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on
RT   complete sequencing: implications for the peopling of South Asia.";
RL   Am. J. Hum. Genet. 75:966-978(2004).
RN   [4] {ECO:0000313|EMBL:BAE08796.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HNsq0191 {ECO:0000313|EMBL:BAE12802.1}, KAsq0057
RC   {ECO:0000313|EMBL:BAE10421.1}, ONsq0136 {ECO:0000313|EMBL:BAE12087.1},
RC   and PDsq0032 {ECO:0000313|EMBL:BAE08796.1};
RX   PubMed=15466285; DOI=10.1101/gr.2286304;
RA   Tanaka M., Cabrera V.M., Gonzalez A.M., Larruga J.M., Takeyasu T., Fuku N.,
RA   Guo L., Hirose R., Fujita Y., Kurata M., Shinoda K., Umetsu K., Yamada Y.,
RA   Oshida Y., Sato Y., Hattori N., Mizuno Y., Arai Y., Hirose N., Ohta S.,
RA   Ogawa O., Tanaka Y., Kawamori R., Shamoto-Nagai M., Maruyama W.,
RA   Shimokata H., Suzuki R., Shimodaira H.;
RT   "Mitochondrial genome variation in eastern Asia and the peopling of
RT   Japan.";
RL   Genome Res. 14:1832-1850(2004).
RN   [5] {ECO:0000313|EMBL:BAE12087.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ONsq0136 {ECO:0000313|EMBL:BAE12087.1};
RA   Guo L., Oshida Y., Fuku N., Takeyasu T., Fujita Y., Kurata M., Sato Y.,
RA   Ito M., Tanaka M.;
RT   "Mitochondrial genome polymorphisms associated with type-2 diabetes or
RT   obesity.";
RL   Mitochondrion 0:0-0(2004).
RN   [6] {ECO:0000313|EMBL:ABB45497.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=IND8 {ECO:0000313|EMBL:ABB45497.1};
RX   PubMed=15804362; DOI=10.1186/1471-2148-5-26;
RA   Rajkumar R., Banerjee J., Gunturi H.B., Trivedi R., Kashyap V.K.;
RT   "Phylogeny and antiquity of M macrohaplogroup inferred from complete mt DNA
RT   sequence of Indian specific lineages.";
RL   BMC Evol. Biol. 5:26-26(2005).
RN   [7] {ECO:0000313|EMBL:BAG38749.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4 {ECO:0000313|EMBL:BAG38749.1};
RX   PubMed=16048457; DOI=10.1111/j.1440-1819.2005.01404.x;
RA   Kazuno A., Munakata K., Mori K., Tanaka M., Nanko S., Kunugi H.,
RA   Umekage T., Tochigi M., Kohda K., Sasaki T., Akiyama T., Washizuka S.,
RA   Kato N., Kato T.;
RT   "Mitochondrial DNA sequence analysis of patients with 'atypical
RT   psychosis'.";
RL   Psychiatry Clin. Neurosci. 59:497-503(2005).
RN   [8] {ECO:0000313|EMBL:BAE08796.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HNsq0191 {ECO:0000313|EMBL:BAE12802.1}, KAsq0057
RC   {ECO:0000313|EMBL:BAE10421.1}, ONsq0136 {ECO:0000313|EMBL:BAE12087.1},
RC   and PDsq0032 {ECO:0000313|EMBL:BAE08796.1};
RA   Tanaka M.;
RT   "Human mitochondrial genome polymorphism database (mtSNP).";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:AAZ02298.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AS74 {ECO:0000313|EMBL:AAZ02298.1};
RX   PubMed=16172508; DOI=10.1534/genetics.105.043901;
RA   Kivisild T., Shen P., Wall D.P., Do B., Sung R., Davis K.K., Passarino G.,
RA   Underhill P.A., Scharfe C., Torroni A., Scozzari R., Modiano D., Coppa A.,
RA   de Knjiff P., Feldman M.W., Cavalli-Sforza L.L., Oefner P.J.;
RT   "The role of selection in the evolution of human mitochondrial genomes.";
RL   Genetics 172:373-387(2006).
RN   [10] {ECO:0000313|EMBL:BAG38749.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4 {ECO:0000313|EMBL:BAG38749.1};
RX   PubMed=16895436; DOI=10.1371/journal.pgen.0020128;
RA   Kazuno A., Munakata K., Nagai T., Shimozono S., Tanaka M., Yoneda M.,
RA   Kato N., Miyawaki A., Kato T.;
RT   "Identification of mitochondrial DNA polymorphisms that alter mitochondrial
RT   matrix pH and intracellular calcium dynamics.";
RL   PLoS Genet. 2:e128-e128(2006).
RN   [11] {ECO:0000313|EMBL:BAG38749.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4 {ECO:0000313|EMBL:BAG38749.1};
RA   Kazuno A., Munakata K., Mori K., Nanko S., Kunugi H., Nakamura K., Mori N.,
RA   Yamada K., Yoshikawa T., Kato N., Kato T.;
RT   "Mitochondrial DNA haplogroup analysis in patients with Bipolar Disorder.";
RL   Am. J. Med. Genet. B Neuropsychiatr. Genet. 0:0-0(2008).
RN   [12] {ECO:0000313|EMBL:BAG38749.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4 {ECO:0000313|EMBL:BAG38749.1};
RX   PubMed=17288645;
RA   Kazuno A., Munakata K., Kato N., Kato T.;
RT   "Mitochondrial DNA-dependent effects of valproate on mitochondrial calcium
RT   levels in transmitochondrial cybrids.";
RL   Int. J. Neuropsychopharmacol. 11:71-78(2008).
RN   [13] {ECO:0000313|EMBL:BAG38749.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4 {ECO:0000313|EMBL:BAG38749.1};
RX   PubMed=18226984; DOI=10.1016/j.mito.2007.12.002;
RA   Kazuno A., Munakata K., Tanaka M., Kato N., Kato T.;
RT   "Relationships between mitochondrial DNA subhaplogroups and intracellular
RT   calcium dynamics.";
RL   Mitochondrion 8:164-169(2008).
RN   [14] {ECO:0000313|EMBL:ABL61830.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SL003 {ECO:0000313|EMBL:ABL61830.1};
RX   PubMed=18359946; DOI=10.1093/molbev/msn068;
RA   Soares P., Trejaut J.A., Loo J.H., Hill C., Mormina M., Lee C.L.,
RA   Chen Y.M., Hudjashov G., Forster P., Macaulay V., Bulbeck D.,
RA   Oppenheimer S., Lin M., Richards M.B.;
RT   "Climate change and postglacial human dispersals in southeast Asia.";
RL   Mol. Biol. Evol. 25:1209-1218(2008).
RN   [15] {ECO:0000313|EMBL:ACS48574.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Fuj5202B {ECO:0000313|EMBL:ACS48574.1};
RA   Trejaut J.A., Loo J.H., Lin M.;
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:ACS48574.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Fuj5202B {ECO:0000313|EMBL:ACS48574.1};
RX   PubMed=19755666; DOI=10.1093/molbev/msp215;
RA   Tabbada K.A., Trejaut J., Loo J.H., Chen Y.M., Lin M., Mirazon-Lahr M.,
RA   Kivisild T., De Ungria M.C.;
RT   "Philippine mitochondrial DNA diversity: a populated viaduct between Taiwan
RT   and Indonesia?";
RL   Mol. Biol. Evol. 27:21-31(2010).
RN   [17] {ECO:0000313|EMBL:AFF67445.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22482806; DOI=10.1016/j.ajhg.2012.03.002;
RA   Behar D.M., van Oven M., Rosset S., Metspalu M., Loogvali E.L., Silva N.M.,
RA   Kivisild T., Torroni A., Villems R.;
RT   "A "Copernican" reassessment of the human mitochondrial DNA tree from its
RT   root.";
RL   Am. J. Hum. Genet. 90:675-684(2012).
RN   [18] {ECO:0000313|EMBL:AFI53791.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22560092; DOI=10.1016/j.ajhg.2012.04.003;
RA   Pala M., Olivieri A., Achilli A., Accetturo M., Metspalu E., Reidla M.,
RA   Tamm E., Karmin M., Reisberg T., Hooshiar Kashani B., Perego U.A.,
RA   Carossa V., Gandini F., Pereira J.B., Soares P., Angerhofer N., Rychkov S.,
RA   Al-Zahery N., Carelli V., Sanati M.H., Houshmand M., Hatina J.,
RA   Macaulay V., Pereira L., Woodward S.R., Davies W., Gamble C., Baird D.,
RA   Semino O., Villems R., Torroni A., Richards M.B.;
RT   "Mitochondrial DNA signals of late glacial recolonization of europe from
RT   near eastern refugia.";
RL   Am. J. Hum. Genet. 90:915-924(2012).
RN   [19] {ECO:0000313|EMBL:AEQ26493.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22096215; DOI=10.1093/molbev/msr245;
RA   Soares P., Alshamali F., Pereira J.B., Fernandes V., Silva N.M., Afonso C.,
RA   Costa M.D., Musilova E., Macaulay V., Richards M.B., Cerny V., Pereira L.;
RT   "The Expansion of mtDNA Haplogroup L3 within and out of Africa.";
RL   Mol. Biol. Evol. 29:915-927(2012).
RN   [20] {ECO:0000313|EMBL:AGD87064.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23332919; DOI=10.1016/j.ajhg.2012.12.010;
RA   Barbieri C., Vicente M., Rocha J., Mpoloka S.W., Stoneking M.,
RA   Pakendorf B.;
RT   "Ancient substructure in early mtDNA lineages of southern Africa.";
RL   Am. J. Hum. Genet. 92:285-292(2013).
RN   [21] {ECO:0000313|EMBL:AGL11513.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24006865;
RA   Fang Y., Huang J., Zhang J., Wang J., Qiao F., Chen H.M., Hong Z.P.;
RT   "Detecting the somatic mutations spectrum of Chinese lung cancer by
RT   analyzing the whole mitochondrial DNA genomes.";
RL   Mitochondrial DNA 0:0-0(2013).
RN   [22] {ECO:0000313|EMBL:BAN80673.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mikami E., Fuku N., Kong Q.P., Takahashi H., Ohiwa N., Murakami H.,
RA   Miyachi M., Pitsiladis Y.P., Higuchi M., Kawahara T., Tanaka M.;
RT   "Comprehensive analysis of common and rare mitochondrial DNA variants in
RT   elite Japanese athletes: Case-control study.";
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN   [23] {ECO:0000313|EMBL:AHI96055.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhang Y.P., Zhou T.C., Yang Y.;
RT   "Two matrilineal inheritance type 2 diabetes families are independent of
RT   mitochondrial mutations.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [24] {ECO:0000313|EMBL:AIN38038.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25301575; DOI=10.1186/s12862-014-0217-9;
RA   Derenko M., Malyarchuk B., Denisova G., Perkova M., Litvinov A.,
RA   Grzybowski T., Dambueva I., Skonieczna K., Rogalla U., Tsybovsky I.,
RA   Zakharov I.;
RT   "Western Eurasian ancestry in modern Siberians based on mitogenomic data.";
RL   BMC Evol. Biol. 14:217-217(2014).
RN   [25] {ECO:0000313|EMBL:AGZ77127.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25254093; DOI=10.1186/2041-2223-5-13;
RA   Lippold S., Xu H., Ko A., Li M., Renaud G., Butthof A., Schroder R.,
RA   Stoneking M.;
RT   "Human paternal and maternal demographic histories: insights from high-
RT   resolution Y chromosome and mtDNA sequences.";
RL   Investig Genet 5:13-13(2014).
RN   [26] {ECO:0000313|EMBL:AHX53961.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zheng H.-X., Qin Z.-D., Jin L., Jin L.;
RT   "The mitochondrial DNA diversity of HGDP populations.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
RN   [27] {ECO:0000313|EMBL:ANA92273.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=27498855; DOI=10.1038/srep31083;
RA   Kang L., Zheng H.X., Zhang M., Yan S., Li L., Liu L., Liu K., Hu K.,
RA   Chen F., Ma L., Qin Z., Wang Y., Wang X., Jin L.;
RT   "MtDNA analysis reveals enriched pathogenic mutations in Tibetan
RT   highlanders.";
RL   Sci. Rep. 6:31083-31083(2016).
RN   [28] {ECO:0000313|EMBL:ASS04522.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28716916; DOI=10.1073/pnas.1704906114;
RA   Pierron D., Heiske M., Razafindrazaka H., Rakoto I., Rabetokotany N.,
RA   Ravololomanga B., Rakotozafy L.M., Rakotomalala M.M., Razafiarivony M.,
RA   Rasoarifetra B., Raharijesy M.A., Razafindralambo L., Ramilisonina,
RA   Fanony F., Lejamble S., Thomas O., Mohamed Abdallah A., Rocher C.,
RA   Arachiche A., Tonaso L., Pereda-Loth V., Schiavinato S., Brucato N.,
RA   Ricaut F.X., Kusuma P., Sudoyo H., Ni S., Boland A., Deleuze J.F.,
RA   Beaujard P., Grange P., Adelaar S., Stoneking M., Rakotoarisoa J.A.,
RA   Radimilahy C., Letellier T.;
RT   "Genomic landscape of human diversity across Madagascar.";
RL   Proc. Natl. Acad. Sci. U.S.A. 114:E6498-E6506(2017).
RN   [29] {ECO:0000313|EMBL:QBZ74875.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Al-Jasmi F.A., Vijayan R., Souid A.-K., Amiri K.;
RT   "Mitochondrial DNA Variations among Emiratis.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [30] {ECO:0000313|EMBL:AVL85028.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=29483671; DOI=10.1038/s41431-018-0113-7;
RA   Kutanan W., Kampuansai J., Brunelli A., Ghirotto S., Pittayaporn P.,
RA   Ruangchai S., Schroder R., Macholdt E., Srikummool M., Kangwanpong D.,
RA   Hubner A., Arias L., Stoneking M.;
RT   "New insights from Thailand into the maternal genetic history of Mainland
RT   Southeast Asia.";
RL   Eur. J. Hum. Genet. 26:898-911(2018).
RN   [31] {ECO:0000313|EMBL:AZJ13854.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30594063; DOI=10.1016/j.fsigen.2018.12.007;
RA   Simao F., Strobl C., Vullo C., Catelli L., Machado P., Huber N.,
RA   Schnaller L., Huber G., Xavier C., Carvalho E.F., Gusmao L., Parson W.;
RT   "The maternal inheritance of Alto Parana revealed by full mitogenome
RT   sequences.";
RL   Forensic Sci. Int. Genet. 39:66-72(2018).
RN   [32] {ECO:0000313|EMBL:AZJ09794.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Piotrowska-Nowak A., Elson J.L., Sobczyk-Kopciol A., Drygas W.,
RA   Piwonska A., Puch-Walczak A., Ploski R., Bartnik E., Tonska K.;
RT   "New mtDNA association model, MutPred variant load, suggests individuals
RT   with multiple mildly deleterious mtDNA variants are more likely to suffer
RT   from atherosclerosis.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [33] {ECO:0000313|EMBL:QBY38194.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30950284;
RA   Zhao D., Ding Y., Lin H., Chen X., Shen W., Gao M., Wei Q., Zhou S.,
RA   Liu X., He N.;
RT   "Mitochondrial haplogroups N9 and G are associated with metabolic syndrome
RT   among HIV-infected patients in China.";
RL   AIDS Res. Hum. Retroviruses 0:0-0(2019).
RN   [34] {ECO:0000313|EMBL:QCB17985.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Tooth {ECO:0000313|EMBL:QCB17985.1};
RX   PubMed=30964548; DOI=.1002/ajpa.23820;
RA   Klunk J., Duggan A.T., Redfern R., Gamble J., Boldsen J.L., Golding G.B.,
RA   Walter B.S., Eaton K., Stangroom J., Rouillard J.M., Devault A.,
RA   DeWitte S.N., Poinar H.N.;
RT   "Genetic resiliency and the Black Death: No apparent loss of mitogenomic
RT   diversity due to the Black Death in medieval London and Denmark.";
RL   Am. J. Phys. Anthropol. 169:240-252(2019).
RN   [35] {ECO:0000313|EMBL:QXO91410.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DH040 {ECO:0000313|EMBL:QXO91410.1};
RA   USDA Swine Surveillance A., Lin K., Dunn D., Zhang J., Gauger P.;
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC       mitochondrial electron transport chain which drives oxidative
CC       phosphorylation. The respiratory chain contains 3 multisubunit
CC       complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC       cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC       CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC       transfer electrons derived from NADH and succinate to molecular oxygen,
CC       creating an electrochemical gradient over the inner membrane that
CC       drives transmembrane transport and the ATP synthase. Cytochrome c
CC       oxidase is the component of the respiratory chain that catalyzes the
CC       reduction of oxygen to water. Electrons originating from reduced
CC       cytochrome c in the intermembrane space (IMS) are transferred via the
CC       dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC       to the active site in subunit 1, a binuclear center (BNC) formed by
CC       heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC       water molecules using 4 electrons from cytochrome c in the IMS and 4
CC       protons from the mitochondrial matrix. {ECO:0000256|RuleBase:RU000457}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC         [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC         Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=7.1.1.9;
CC         Evidence={ECO:0000256|ARBA:ARBA00029331};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11437;
CC         Evidence={ECO:0000256|ARBA:ARBA00029331};
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000256|RuleBase:RU000457};
CC       Note=Binds a copper A center. {ECO:0000256|RuleBase:RU000457};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       inner membrane {ECO:0000256|ARBA:ARBA00004448,
CC       ECO:0000256|RuleBase:RU000457}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU000457}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
CC       {ECO:0000256|ARBA:ARBA00007866, ECO:0000256|RuleBase:RU000457}.
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DR   EMBL; AF347008; AAK17795.1; -; Genomic_DNA.
DR   EMBL; AY714004; AAU02491.1; -; Genomic_DNA.
DR   EMBL; DQ112879; AAZ02298.1; -; Genomic_DNA.
DR   EMBL; DQ246818; ABB45497.1; -; Genomic_DNA.
DR   EMBL; EF093554; ABL61830.1; -; Genomic_DNA.
DR   EMBL; GQ119008; ACS48574.1; -; Genomic_DNA.
DR   EMBL; JN655781; AEQ26493.1; -; Genomic_DNA.
DR   EMBL; JQ702268; AFF67445.1; -; Genomic_DNA.
DR   EMBL; JQ798080; AFI53791.1; -; Genomic_DNA.
DR   EMBL; KC346162; AGD87064.1; -; Genomic_DNA.
DR   EMBL; KC733262; AGL11513.1; -; Genomic_DNA.
DR   EMBL; KC733263; AGL11526.2; -; Genomic_DNA.
DR   EMBL; KC733264; AGL11539.1; -; Genomic_DNA.
DR   EMBL; KF451807; AGZ77127.1; -; Genomic_DNA.
DR   EMBL; KF898135; AHI96055.1; -; Genomic_DNA.
DR   EMBL; KF898137; AHI96081.1; -; Genomic_DNA.
DR   EMBL; KF898138; AHI96094.1; -; Genomic_DNA.
DR   EMBL; KF898139; AHI96107.1; -; Genomic_DNA.
DR   EMBL; KF898140; AHI96120.1; -; Genomic_DNA.
DR   EMBL; KF898142; AHI96146.1; -; Genomic_DNA.
DR   EMBL; KF898143; AHI96159.1; -; Genomic_DNA.
DR   EMBL; KF898144; AHI96172.1; -; Genomic_DNA.
DR   EMBL; KJ446608; AHX53961.1; -; Genomic_DNA.
DR   EMBL; KJ856734; AIN38038.1; -; Genomic_DNA.
DR   EMBL; KJ856776; AIN38584.1; -; Genomic_DNA.
DR   EMBL; KT725882; ANA92273.1; -; Genomic_DNA.
DR   EMBL; KT725891; ANA92390.1; -; Genomic_DNA.
DR   EMBL; KT725907; ANA92598.1; -; Genomic_DNA.
DR   EMBL; KT725908; ANA92611.1; -; Genomic_DNA.
DR   EMBL; KT725909; ANA92624.1; -; Genomic_DNA.
DR   EMBL; KT725930; ANA92895.1; -; Genomic_DNA.
DR   EMBL; KT725956; ANA93231.1; -; Genomic_DNA.
DR   EMBL; MF056584; ASS04522.1; -; Genomic_DNA.
DR   EMBL; MG272585; AVL85028.1; -; Genomic_DNA.
DR   EMBL; MG272698; AVL86497.1; -; Genomic_DNA.
DR   EMBL; MG272699; AVL86510.1; -; Genomic_DNA.
DR   EMBL; MH120553; AZJ09794.1; -; Genomic_DNA.
DR   EMBL; MH981837; AZJ13854.1; -; Genomic_DNA.
DR   EMBL; AP008370; BAE08796.1; -; Genomic_DNA.
DR   EMBL; AP008495; BAE10421.1; -; Genomic_DNA.
DR   EMBL; AP008623; BAE12087.1; -; Genomic_DNA.
DR   EMBL; AP008678; BAE12802.1; -; Genomic_DNA.
DR   EMBL; AP009422; BAG38749.1; -; Genomic_DNA.
DR   EMBL; AP013218; BAN80673.1; -; Genomic_DNA.
DR   EMBL; MH553792; QBY38194.1; -; Genomic_DNA.
DR   EMBL; MF437126; QBZ74875.1; -; Genomic_DNA.
DR   EMBL; MK059598; QCB17985.1; -; Genomic_DNA.
DR   EMBL; MN628065; QXO91410.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9B2U8; -.
DR   SMR; Q9B2U8; -.
DR   PeptideAtlas; Q9B2U8; -.
DR   ChiTaRS; MT-CO2; human.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:TreeGrafter.
DR   CDD; cd13912; CcO_II_C; 1.
DR   Gene3D; 1.10.287.90; -; 1.
DR   Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 1.
DR   InterPro; IPR045187; CcO_II.
DR   InterPro; IPR002429; CcO_II-like_C.
DR   InterPro; IPR034210; CcO_II_C.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR014222; Cyt_c_oxidase_su2.
DR   InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR   InterPro; IPR036257; Cyt_c_oxidase_su2_TM_sf.
DR   NCBIfam; TIGR02866; CoxB; 1.
DR   PANTHER; PTHR22888:SF9; CYTOCHROME C OXIDASE SUBUNIT 2; 1.
DR   PANTHER; PTHR22888; CYTOCHROME C OXIDASE, SUBUNIT II; 1.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   PRINTS; PR01166; CYCOXIDASEII.
DR   SUPFAM; SSF49503; Cupredoxins; 1.
DR   SUPFAM; SSF81464; Cytochrome c oxidase subunit II-like, transmembrane region; 1.
DR   PROSITE; PS00078; COX2; 1.
DR   PROSITE; PS50857; COX2_CUA; 1.
DR   PROSITE; PS50999; COX2_TM; 1.
PE   3: Inferred from homology;
KW   Copper {ECO:0000256|ARBA:ARBA00023008, ECO:0000256|RuleBase:RU000457};
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982,
KW   ECO:0000256|RuleBase:RU000457}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000457};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000457};
KW   Mitochondrion {ECO:0000256|RuleBase:RU000457, ECO:0000313|EMBL:AAK17795.1};
KW   Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000457};
KW   Respiratory chain {ECO:0000256|ARBA:ARBA00022660,
KW   ECO:0000256|RuleBase:RU000457};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000457};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000457}.
FT   TRANSMEM        27..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        66..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..91
FT                   /note="Cytochrome oxidase subunit II transmembrane region
FT                   profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50999"
FT   DOMAIN          92..225
FT                   /note="Cytochrome oxidase subunit II copper A binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50857"
SQ   SEQUENCE   227 AA;  25551 MW;  799836363CB4FF7C CRC64;
     MAHAAQVGLQ DATSPIMEEL ITFHDHALMV IFLICFLVLY ALFLTLTTKL TNTNISDAQE
     METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS
     YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN
     QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL
//