ID   Q9B2U8_HUMAN            Unreviewed;       227 AA.
AC   Q9B2U8;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   05-JUL-2017, entry version 131.
DE   RecName: Full=Cytochrome c oxidase subunit 2 {ECO:0000256|RuleBase:RU000457, ECO:0000256|SAAS:SAAS00709560};
GN   Name=COX2 {ECO:0000313|EMBL:AAU02491.1};
GN   Synonyms=COII {ECO:0000313|EMBL:BAE08796.1}, coxII
GN   {ECO:0000313|EMBL:BAN80673.1};
OS   Homo sapiens (Human).
OG   Mitochondrion {ECO:0000313|EMBL:AAK17795.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAK17795.1};
RN   [1] {ECO:0000313|EMBL:AAK17795.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11130070; DOI=10.1038/35047064;
RA   Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.;
RT   "Mitochondrial genome variation and the origin of modern humans.";
RL   Nature 408:708-713(2000).
RN   [2] {ECO:0000313|EMBL:AAK17795.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Ingman M., Kaessmann H., Paabo S., Gyllensten U.;
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAU02491.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C22 {ECO:0000313|EMBL:AAU02491.1};
RX   PubMed=15467980; DOI=10.1086/425871;
RA   Palanichamy M.G., Sun C., Agrawal S., Bandelt H.-J., Kong Q.-P.,
RA   Khan F., Wang C.Y., Chaudhuri T.K., Palla V., Zhang Y.-P.;
RT   "Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on
RT   complete sequencing: implications for the peopling of South Asia.";
RL   Am. J. Hum. Genet. 75:966-978(2004).
RN   [4] {ECO:0000313|EMBL:BAE08796.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HNsq0191 {ECO:0000313|EMBL:BAE12802.1}, KAsq0057
RC   {ECO:0000313|EMBL:BAE10421.1}, ONsq0136 {ECO:0000313|EMBL:BAE12087.1},
RC   and PDsq0032 {ECO:0000313|EMBL:BAE08796.1};
RX   PubMed=15466285; DOI=10.1101/gr.2286304;
RA   Tanaka M., Cabrera V.M., Gonzalez A.M., Larruga J.M., Takeyasu T.,
RA   Fuku N., Guo L., Hirose R., Fujita Y., Kurata M., Shinoda K.,
RA   Umetsu K., Yamada Y., Oshida Y., Sato Y., Hattori N., Mizuno Y.,
RA   Arai Y., Hirose N., Ohta S., Ogawa O., Tanaka Y., Kawamori R.,
RA   Shamoto-Nagai M., Maruyama W., Shimokata H., Suzuki R., Shimodaira H.;
RT   "Mitochondrial genome variation in eastern Asia and the peopling of
RT   Japan.";
RL   Genome Res. 14:1832-1850(2004).
RN   [5] {ECO:0000313|EMBL:BAE12087.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ONsq0136 {ECO:0000313|EMBL:BAE12087.1};
RA   Guo L., Oshida Y., Fuku N., Takeyasu T., Fujita Y., Kurata M.,
RA   Sato Y., Ito M., Tanaka M.;
RT   "Mitochondrial genome polymorphisms associated with type-2 diabetes or
RT   obesity.";
RL   Mitochondrion 0:0-0(2004).
RN   [6] {ECO:0000313|EMBL:ABB45497.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=IND8 {ECO:0000313|EMBL:ABB45497.1};
RX   PubMed=15804362; DOI=10.1186/1471-2148-5-26;
RA   Rajkumar R., Banerjee J., Gunturi H.B., Trivedi R., Kashyap V.K.;
RT   "Phylogeny and antiquity of M macrohaplogroup inferred from complete
RT   mt DNA sequence of Indian specific lineages.";
RL   BMC Evol. Biol. 5:26-26(2005).
RN   [7] {ECO:0000313|EMBL:BAG38749.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4 {ECO:0000313|EMBL:BAG38749.1};
RX   PubMed=16048457; DOI=10.1111/j.1440-1819.2005.01404.x;
RA   Kazuno A., Munakata K., Mori K., Tanaka M., Nanko S., Kunugi H.,
RA   Umekage T., Tochigi M., Kohda K., Sasaki T., Akiyama T., Washizuka S.,
RA   Kato N., Kato T.;
RT   "Mitochondrial DNA sequence analysis of patients with 'atypical
RT   psychosis'.";
RL   Psychiatry Clin. Neurosci. 59:497-503(2005).
RN   [8] {ECO:0000313|EMBL:BAE08796.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HNsq0191 {ECO:0000313|EMBL:BAE12802.1}, KAsq0057
RC   {ECO:0000313|EMBL:BAE10421.1}, ONsq0136 {ECO:0000313|EMBL:BAE12087.1},
RC   and PDsq0032 {ECO:0000313|EMBL:BAE08796.1};
RA   Tanaka M.;
RT   "Human mitochondrial genome polymorphism database (mtSNP).";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:AAZ02298.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AS74 {ECO:0000313|EMBL:AAZ02298.1};
RX   PubMed=16172508; DOI=10.1534/genetics.105.043901;
RA   Kivisild T., Shen P., Wall D.P., Do B., Sung R., Davis K.K.,
RA   Passarino G., Underhill P.A., Scharfe C., Torroni A., Scozzari R.,
RA   Modiano D., Coppa A., de Knjiff P., Feldman M.W., Cavalli-Sforza L.L.,
RA   Oefner P.J.;
RT   "The role of selection in the evolution of human mitochondrial
RT   genomes.";
RL   Genetics 172:373-387(2006).
RN   [10] {ECO:0000313|EMBL:BAG38749.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4 {ECO:0000313|EMBL:BAG38749.1};
RX   PubMed=16895436; DOI=10.1371/journal.pgen.0020128;
RA   Kazuno A., Munakata K., Nagai T., Shimozono S., Tanaka M., Yoneda M.,
RA   Kato N., Miyawaki A., Kato T.;
RT   "Identification of mitochondrial DNA polymorphisms that alter
RT   mitochondrial matrix pH and intracellular calcium dynamics.";
RL   PLoS Genet. 2:e128-e128(2006).
RN   [11] {ECO:0000313|EMBL:BAG38749.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4 {ECO:0000313|EMBL:BAG38749.1};
RA   Kazuno A., Munakata K., Mori K., Nanko S., Kunugi H., Nakamura K.,
RA   Mori N., Yamada K., Yoshikawa T., Kato N., Kato T.;
RT   "Mitochondrial DNA haplogroup analysis in patients with Bipolar
RT   Disorder.";
RL   Am. J. Med. Genet. B Neuropsychiatr. Genet. 0:0-0(2008).
RN   [12] {ECO:0000313|EMBL:BAG38749.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4 {ECO:0000313|EMBL:BAG38749.1};
RX   PubMed=17288645;
RA   Kazuno A., Munakata K., Kato N., Kato T.;
RT   "Mitochondrial DNA-dependent effects of valproate on mitochondrial
RT   calcium levels in transmitochondrial cybrids.";
RL   Int. J. Neuropsychopharmacol. 11:71-78(2008).
RN   [13] {ECO:0000313|EMBL:BAG38749.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mdmd4 {ECO:0000313|EMBL:BAG38749.1};
RX   PubMed=18226984; DOI=10.1016/j.mito.2007.12.002;
RA   Kazuno A., Munakata K., Tanaka M., Kato N., Kato T.;
RT   "Relationships between mitochondrial DNA subhaplogroups and
RT   intracellular calcium dynamics.";
RL   Mitochondrion 8:164-169(2008).
RN   [14] {ECO:0000313|EMBL:ABL61830.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SL003 {ECO:0000313|EMBL:ABL61830.1};
RX   PubMed=18359946; DOI=10.1093/molbev/msn068;
RA   Soares P., Trejaut J.A., Loo J.H., Hill C., Mormina M., Lee C.L.,
RA   Chen Y.M., Hudjashov G., Forster P., Macaulay V., Bulbeck D.,
RA   Oppenheimer S., Lin M., Richards M.B.;
RT   "Climate change and postglacial human dispersals in southeast Asia.";
RL   Mol. Biol. Evol. 25:1209-1218(2008).
RN   [15] {ECO:0000313|EMBL:ACS48574.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Fuj5202B {ECO:0000313|EMBL:ACS48574.1};
RA   Trejaut J.A., Loo J.H., Lin M.;
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:ACS48574.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Fuj5202B {ECO:0000313|EMBL:ACS48574.1};
RX   PubMed=19755666; DOI=10.1093/molbev/msp215;
RA   Tabbada K.A., Trejaut J., Loo J.H., Chen Y.M., Lin M.,
RA   Mirazon-Lahr M., Kivisild T., De Ungria M.C.;
RT   "Philippine mitochondrial DNA diversity: a populated viaduct between
RT   Taiwan and Indonesia?";
RL   Mol. Biol. Evol. 27:21-31(2010).
RN   [17] {ECO:0000313|EMBL:AFF67445.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22482806; DOI=10.1016/j.ajhg.2012.03.002;
RA   Behar D.M., van Oven M., Rosset S., Metspalu M., Loogvali E.L.,
RA   Silva N.M., Kivisild T., Torroni A., Villems R.;
RT   "A "Copernican" reassessment of the human mitochondrial DNA tree from
RT   its root.";
RL   Am. J. Hum. Genet. 90:675-684(2012).
RN   [18] {ECO:0000313|EMBL:AFI53791.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22560092; DOI=10.1016/j.ajhg.2012.04.003;
RA   Pala M., Olivieri A., Achilli A., Accetturo M., Metspalu E.,
RA   Reidla M., Tamm E., Karmin M., Reisberg T., Hooshiar Kashani B.,
RA   Perego U.A., Carossa V., Gandini F., Pereira J.B., Soares P.,
RA   Angerhofer N., Rychkov S., Al-Zahery N., Carelli V., Sanati M.H.,
RA   Houshmand M., Hatina J., Macaulay V., Pereira L., Woodward S.R.,
RA   Davies W., Gamble C., Baird D., Semino O., Villems R., Torroni A.,
RA   Richards M.B.;
RT   "Mitochondrial DNA signals of late glacial recolonization of europe
RT   from near eastern refugia.";
RL   Am. J. Hum. Genet. 90:915-924(2012).
RN   [19] {ECO:0000313|EMBL:AEQ26493.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22096215; DOI=10.1093/molbev/msr245;
RA   Soares P., Alshamali F., Pereira J.B., Fernandes V., Silva N.M.,
RA   Afonso C., Costa M.D., Musilova E., Macaulay V., Richards M.B.,
RA   Cerny V., Pereira L.;
RT   "The Expansion of mtDNA Haplogroup L3 within and out of Africa.";
RL   Mol. Biol. Evol. 29:915-927(2012).
RN   [20] {ECO:0000313|EMBL:AGD87064.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23332919; DOI=10.1016/j.ajhg.2012.12.010;
RA   Barbieri C., Vicente M., Rocha J., Mpoloka S.W., Stoneking M.,
RA   Pakendorf B.;
RT   "Ancient substructure in early mtDNA lineages of southern Africa.";
RL   Am. J. Hum. Genet. 92:285-292(2013).
RN   [21] {ECO:0000313|EMBL:AGL11513.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24006865;
RA   Fang Y., Huang J., Zhang J., Wang J., Qiao F., Chen H.M., Hong Z.P.;
RT   "Detecting the somatic mutations spectrum of Chinese lung cancer by
RT   analyzing the whole mitochondrial DNA genomes.";
RL   Mitochondrial DNA 0:0-0(2013).
RN   [22] {ECO:0000313|EMBL:BAN80673.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mikami E., Fuku N., Kong Q.P., Takahashi H., Ohiwa N., Murakami H.,
RA   Miyachi M., Pitsiladis Y.P., Higuchi M., Kawahara T., Tanaka M.;
RT   "Comprehensive analysis of common and rare mitochondrial DNA variants
RT   in elite Japanese athletes: Case-control study.";
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN   [23] {ECO:0000313|EMBL:AHI96055.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhang Y.P., Zhou T.C., Yang Y.;
RT   "Two matrilineal inheritance type 2 diabetes families are independent
RT   of mitochondrial mutations.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [24] {ECO:0000313|EMBL:AIN38038.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25301575; DOI=10.1186/s12862-014-0217-9;
RA   Derenko M., Malyarchuk B., Denisova G., Perkova M., Litvinov A.,
RA   Grzybowski T., Dambueva I., Skonieczna K., Rogalla U., Tsybovsky I.,
RA   Zakharov I.;
RT   "Western Eurasian ancestry in modern Siberians based on mitogenomic
RT   data.";
RL   BMC Evol. Biol. 14:217-217(2014).
RN   [25] {ECO:0000313|EMBL:AGZ77127.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25254093; DOI=10.1186/2041-2223-5-13;
RA   Lippold S., Xu H., Ko A., Li M., Renaud G., Butthof A., Schroder R.,
RA   Stoneking M.;
RT   "Human paternal and maternal demographic histories: insights from
RT   high-resolution Y chromosome and mtDNA sequences.";
RL   Investig Genet 5:13-13(2014).
RN   [26] {ECO:0000313|EMBL:AHX53961.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zheng H.-X., Qin Z.-D., Jin L., Jin L.;
RT   "The mitochondrial DNA diversity of HGDP populations.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
RN   [27] {ECO:0000313|EMBL:ANA92273.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=27498855; DOI=10.1038/srep31083;
RA   Kang L., Zheng H.X., Zhang M., Yan S., Li L., Liu L., Liu K., Hu K.,
RA   Chen F., Ma L., Qin Z., Wang Y., Wang X., Jin L.;
RT   "MtDNA analysis reveals enriched pathogenic mutations in Tibetan
RT   highlanders.";
RL   Sci. Rep. 6:31083-31083(2016).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. Subunit 2
CC       transfers the electrons from cytochrome c via its binuclear copper
CC       A center to the bimetallic center of the catalytic subunit 1.
CC       {ECO:0000256|RuleBase:RU000457}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|SAAS:SAAS00709542}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00709542}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
CC       {ECO:0000256|RuleBase:RU000457, ECO:0000256|SAAS:SAAS00709553}.
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DR   EMBL; AF347008; AAK17795.1; -; Genomic_DNA.
DR   EMBL; AY714004; AAU02491.1; -; Genomic_DNA.
DR   EMBL; DQ112879; AAZ02298.1; -; Genomic_DNA.
DR   EMBL; DQ246818; ABB45497.1; -; Genomic_DNA.
DR   EMBL; EF093554; ABL61830.1; -; Genomic_DNA.
DR   EMBL; GQ119008; ACS48574.1; -; Genomic_DNA.
DR   EMBL; JN655781; AEQ26493.1; -; Genomic_DNA.
DR   EMBL; JQ702268; AFF67445.1; -; Genomic_DNA.
DR   EMBL; JQ798080; AFI53791.1; -; Genomic_DNA.
DR   EMBL; KC346162; AGD87064.1; -; Genomic_DNA.
DR   EMBL; KC733262; AGL11513.1; -; Genomic_DNA.
DR   EMBL; KC733263; AGL11526.2; -; Genomic_DNA.
DR   EMBL; KC733264; AGL11539.1; -; Genomic_DNA.
DR   EMBL; KF451807; AGZ77127.1; -; Genomic_DNA.
DR   EMBL; KF898135; AHI96055.1; -; Genomic_DNA.
DR   EMBL; KF898137; AHI96081.1; -; Genomic_DNA.
DR   EMBL; KF898138; AHI96094.1; -; Genomic_DNA.
DR   EMBL; KF898139; AHI96107.1; -; Genomic_DNA.
DR   EMBL; KF898140; AHI96120.1; -; Genomic_DNA.
DR   EMBL; KF898142; AHI96146.1; -; Genomic_DNA.
DR   EMBL; KF898143; AHI96159.1; -; Genomic_DNA.
DR   EMBL; KF898144; AHI96172.1; -; Genomic_DNA.
DR   EMBL; KJ446608; AHX53961.1; -; Genomic_DNA.
DR   EMBL; KJ856734; AIN38038.1; -; Genomic_DNA.
DR   EMBL; KJ856776; AIN38584.1; -; Genomic_DNA.
DR   EMBL; KT725882; ANA92273.1; -; Genomic_DNA.
DR   EMBL; KT725891; ANA92390.1; -; Genomic_DNA.
DR   EMBL; KT725907; ANA92598.1; -; Genomic_DNA.
DR   EMBL; KT725908; ANA92611.1; -; Genomic_DNA.
DR   EMBL; KT725909; ANA92624.1; -; Genomic_DNA.
DR   EMBL; KT725930; ANA92895.1; -; Genomic_DNA.
DR   EMBL; KT725956; ANA93231.1; -; Genomic_DNA.
DR   EMBL; AP008370; BAE08796.1; -; Genomic_DNA.
DR   EMBL; AP008495; BAE10421.1; -; Genomic_DNA.
DR   EMBL; AP008623; BAE12087.1; -; Genomic_DNA.
DR   EMBL; AP008678; BAE12802.1; -; Genomic_DNA.
DR   EMBL; AP009422; BAG38749.1; -; Genomic_DNA.
DR   EMBL; AP013218; BAN80673.1; -; Genomic_DNA.
DR   SMR; Q9B2U8; -.
DR   eggNOG; KOG4767; Eukaryota.
DR   eggNOG; COG1622; LUCA.
DR   HOVERGEN; HBG012727; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   CDD; cd13912; CcO_II_C; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR002429; CcO_II-like_C.
DR   InterPro; IPR034210; CcO_II_C.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR014222; Cyt_c_oxidase_su2.
DR   InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
DR   SUPFAM; SSF81464; SSF81464; 1.
DR   TIGRFAMs; TIGR02866; CoxB; 1.
DR   PROSITE; PS00078; COX2; 1.
DR   PROSITE; PS50857; COX2_CUA; 1.
DR   PROSITE; PS50999; COX2_TM; 1.
PE   3: Inferred from homology;
KW   Copper {ECO:0000256|RuleBase:RU000457, ECO:0000256|SAAS:SAAS00517791};
KW   Electron transport {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS00517827};
KW   Membrane {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS00809509, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS00517846};
KW   Mitochondrion {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS00709499, ECO:0000313|EMBL:AAK17795.1};
KW   Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS00709564};
KW   Respiratory chain {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS00709567};
KW   Transmembrane {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS00809546, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00809553,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS00517787}.
FT   TRANSMEM     27     46       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     66     85       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     91       COX2_TM. {ECO:0000259|PROSITE:PS50999}.
FT   DOMAIN       92    225       COX2_CUA. {ECO:0000259|PROSITE:PS50857}.
SQ   SEQUENCE   227 AA;  25551 MW;  799836363CB4FF7C CRC64;
     MAHAAQVGLQ DATSPIMEEL ITFHDHALMV IFLICFLVLY ALFLTLTTKL TNTNISDAQE
     METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS
     YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN
     QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL
//