ID   Q9B2U8      PRELIMINARY;      PRT;   227 AA.
AC   Q9B2U8;
DT   01-JUN-2001 (TrEMBLrel. 17, Created)
DT   01-JUN-2001 (TrEMBLrel. 17, Last sequence update)
DT   01-MAR-2004 (TrEMBLrel. 26, Last annotation update)
DE   Cytochrome c oxidase subunit II (EC 1.9.3.1) (Cytochrome c oxidase
DE   polypeptide II).
OS   Homo sapiens (Human).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=21012010; PubMed=11130070;
RA   Ingman M., Kaessmann H., Paabo S., Gyllensten U.;
RT   "Mitochondrial genome variation and the origin of modern humans.";
RL   Nature 408:708-713(2000).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=21176314; PubMed=11279504;
RA   Ingman M., Kaessmann H., Paabo S., Gyllensten U.;
RT   "correction: Mitochondrial genome variation and the origin of modern
RT   humans.";
RL   Nature 410:611-611(2001).
RN   [3]
RP   SEQUENCE FROM N.A.
RA   Ingman M., Kaessmann H., Paabo S., Gyllensten U.;
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. Subunit 2
CC       transfers the electrons from cytochrome c via its binuclear copper
CC       A center to the bimetallic center of the catalytic subunit 1 (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) = 4 ferricytochrome
CC       c + 2 H(2)O.
CC   -!- COFACTOR: Copper A (By similarity).
CC   -!- SUBCELLULAR LOCATION: Integral Membrane Protein. Mitochondrial
CC       inner membrane (By similarity).
CC   -!- SIMILARITY: BELONGS TO THE CYTOCHROME C OXIDASE SUBUNIT 2 FAMILY.
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DR   EMBL; AF347008; AAK17795.1; -.
DR   HSSP; P18400; 1CYX.
DR   GO; GO:0019866; C:inner membrane; IEA.
DR   GO; GO:0016021; C:integral to membrane; IEA.
DR   GO; GO:0005746; C:mitochondrial electron transport chain; IEA.
DR   GO; GO:0005739; C:mitochondrion; IEA.
DR   GO; GO:0005507; F:copper ion binding; IEA.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA.
DR   GO; GO:0006118; P:electron transport; IEA.
DR   GO; GO:0006810; P:transport; IEA.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR002429; Cyt_c_ox_2.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   PRINTS; PR01166; CYCOXIDASEII.
DR   ProDom; PD000131; Copper_CuA; 1.
DR   PROSITE; PS00078; COX2; 1.
KW   Copper; Electron transport; Inner membrane; Membrane; Oxidoreductase;
KW   Respiratory chain; Transmembrane; Transport; Mitochondrion.
SQ   SEQUENCE   227 AA;  25551 MW;  799836363CB4FF7C CRC64;
     MAHAAQVGLQ DATSPIMEEL ITFHDHALMV IFLICFLVLY ALFLTLTTKL TNTNISDAQE
     METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS
     YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN
     QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL
//