ID ARS2_MOUSE Reviewed; 875 AA. AC Q99MR6; Q99MR4; Q99MR5; Q99MR7; DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 10-JUN-2008, entry version 43. DE Arsenite-resistance protein 2. GN Name=Ars2; Synonyms=Asr2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A; B; C AND D). RC STRAIN=129/Sv; RX MEDLINE=21138439; PubMed=11239002; DOI=10.1093/nar/29.6.1352; RA Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., RA Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., RA Miller W., Koop B.F.; RT "Comparative analysis of the gene-dense ACHE/TFR2 region on human RT chromosome 7q22 with the orthologous region on mouse chromosome 5."; RL Nucleic Acids Res. 29:1352-1365(2001). CC -!- FUNCTION: Confers arsenite resistance (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=A; CC IsoId=Q99MR6-1; Sequence=Displayed; CC Name=B; CC IsoId=Q99MR6-2; Sequence=VSP_000325; CC Name=C; CC IsoId=Q99MR6-3; Sequence=VSP_000325, VSP_000326; CC Name=D; CC IsoId=Q99MR6-4; Sequence=VSP_000326; CC -!- SIMILARITY: Belongs to the ARS2 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF312033; AAK28817.1; -; Genomic_DNA. DR EMBL; AF312033; AAK28818.1; -; Genomic_DNA. DR EMBL; AF312033; AAK28819.1; -; Genomic_DNA. DR EMBL; AF312033; AAK28820.1; -; Genomic_DNA. DR RefSeq; NP_113582.1; -. DR UniGene; Mm.387734; -. DR PhosphoSite; Q99MR6; -. DR Ensembl; ENSMUSG00000037364; Mus musculus. DR GeneID; 83701; -. DR MGI; MGI:1933527; Ars2. DR HOGENOM; Q99MR6; -. DR HOVERGEN; Q99MR6; -. DR CleanEx; MM_ARS2; -. DR GermOnline; ENSMUSG00000037364; Mus musculus. DR InterPro; IPR007042; Arsenate-R_2. DR Pfam; PF04959; ARS2; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Phosphoprotein. FT CHAIN 1 875 Arsenite-resistance protein 2. FT /FTId=PRO_0000220966. FT MOD_RES 539 539 Phosphoserine (By similarity). FT MOD_RES 543 543 Phosphothreonine (By similarity). FT MOD_RES 623 623 Phosphotyrosine (By similarity). FT MOD_RES 624 624 Phosphotyrosine (By similarity). FT VAR_SEQ 775 779 ILPPG -> S (in isoform B and isoform C). FT /FTId=VSP_000325. FT VAR_SEQ 809 815 Missing (in isoform C and isoform D). FT /FTId=VSP_000326. SQ SEQUENCE 875 AA; 100452 MW; 9571445674452886 CRC64; MGDSDDEYDR RRRDKFRRER SDYDRSRERD ERRRGDDWND REWDRGRERR SRGEYRDYDR NRRERFSPPR HELSPPQKRM RRDWDEHSSD PYHSGYDMPY AGGGGGPTYG PPQPWGHPDV HIMQHHVLPI QARLGSIAEI DLGVPPPIMK SFKEFLLSLD DSVDETEAVK RYNDYKLDFR RQQMQDFFLA HKDEEWFRSK YHPDEVGKRR QEARGALQNR LKVFLSLMES GWFDNLLLDI DKADAIVKML DAAVIKMEGG TENDLRILEQ EEEEEQAGKT GEASKKEEAR AGPALGEGER KANDKDEKKE DGKQAENDSS NDDKTKKSEG DGDKEEKKEE AEKEAKKSKK RNRKQSGDDS FDEGSVSESE SESEGGQAEE EKEEAEEALK EKEKPKEEEK EKPKDAAGLE CKPRPLHKTC SLFMRNIAPN ISRAEIISLC KRYPGFMRVA LSEPQPERRF FRRGWVTFDR SVNIKEICWN LQNIRLRECE LSPGVNRDLT RRVRNINGIT QHKQIVRNDI KLAAKLIHTL DDRTQLWASE PGTPPVPTSL PSQNPILKNI TDYLIEEVSA EEEELLGSSG GPPPEEPPKE GNPAEINVER DEKLIKVLDK LLLYLRIVHS LDYYNTCEYP NEDEMPNRCG IIHVRGPMPP NRISHGEVLE WQKTFEEKLT PLLSVRESLS EEEAQKMGRK DPEQEVEKFV TSNTQELGKD KWLCPLSGKK FKGPEFVRKH IFNKHAEKIE EVKKEVAFFN NFLTDAKRPA LPEIKPAQPP GPAQILPPGL TPGLPYPHQT PQGLMPYGQP RPPILGYGAG AVRPAVPTGG PPYPHAPYGA GRGNYDAFRG QGGYPGKPRN RMVRGDPRAI VEYRDLDAPD DVDFF //