ID Q998N5 PRELIMINARY; PRT; 621 AA. AC Q998N5; DT 01-JUN-2001 (TrEMBLrel. 17, Created) DT 01-JUN-2001 (TrEMBLrel. 17, Last sequence update) DT 01-OCT-2003 (TrEMBLrel. 25, Last annotation update) DE Hemagglutinin protein. OS Measles virus. OC Viruses; ssRNA negative-strand viruses; Mononegavirales; OC Paramyxoviridae; Paramyxovirinae; Morbillivirus. OX NCBI_TaxID=11234; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Osaka-3; RX MEDLINE=21169672; PubMed=11270608; RA Furukawa K., Ayata M., Kimura M., Seto T., Matsunaga I., Murata R., RA Yamano T., Ogura H.; RT "Hemadsorption expressed by cloned H genes from subacute sclerosing RT panencephalitis (SSPE) viruses and their possible progenitor measles RT viruses isolated in Osaka, Japan."; RL Microbiol. Immunol. 45:59-68(2001). CC -!- FUNCTION: HEMAGGLUTININ IS RESPONSIBLE FOR ATTACHING THE VIRUS TO CC CELL RECEPTORS AND FOR INITIATING INFECTION. NEURAMINIDASE CC ACTIVITY HELPS THE EFFICIENT SPREAD OF THE VIRUS BY DISSOCIATING CC THE MATURE VIRIONS FROM THE NEURAMINIC ACID CONTAINING CC GLYCOPROTEINS. CC -!- CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, CC alpha-(2->8)-glycosidic linkages of terminal sialic residues in CC oligosaccharides, glycoproteins, glycolipids, colominic acid and CC synthetic substrates. CC -!- SUBCELLULAR LOCATION: External, anchored to the envelope by its N- CC terminal hydrophobic sequence. CC -!- SIMILARITY: Belongs to the paramyxoviruses hemagglutinin- CC neuraminidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB045307; BAB39847.1; -. DR PIR; PQ0377; PQ0377. DR PIR; PQ0381; PQ0381. DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA. DR GO; GO:0019058; P:viral infectious cycle; IEA. DR InterPro; IPR000665; Hem-neuramndse. DR Pfam; PF00423; HN; 1. KW Glycoprotein; Hemagglutinin; Hydrolase; Transmembrane. SQ SEQUENCE 621 AA; 69656 MW; 0D49717D1D630F11 CRC64; MSPQRDRTNA FHKDNPHPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI GLLAIAGIRL HWAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG DEVGLRIPQR FTDLVKFISD KIKFLNLDRE YNFRDLTWCI NPPERIKLDY DQYCADVAAE ELMNALVNST LLETRTTNQF LAVSKGNCSG PTTIRGQLSN MSLSLLDLYL SRGYNVSSII TMTSQGMYGG TYLVEKPNLS SKGSELSQLS IYRVFEVGVI RNPGLGAPVF HMTNYFEQPV SNDLSNCMVA LGELKLAALC HGEDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMQSWVPLS TDDPVIDRLY LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA PLKDNRIPSY GVLSVNLSLT VELKIKIASG FGPLITHGSG MDLYKSNHNN VYWLTIPPMK NLALGVINTL EWIPRFKVSP NFFTVPIKEA GEDCHAPTYL PAEVDGDVNL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPSRSFS YFYPFRLPIK GVPIELQVEC FTWDQKLWCR HFCVLADSES GGHITHSGMV GMGVSCTVTR EDGTNRRYSR Q //