ID H2AE_HUMAN STANDARD; PRT; 127 AA. AC Q99878; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Histone H2A.e (H2A/e). GN Name=HIST1H2AK; Synonyms=H2AFE; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98102829; PubMed=9439656; RA Albig W., Doenecke D.; RT "The human histone gene cluster at the D6S105 locus."; RL Hum. Genet. 101:284-294(1997). CC -!- SUBUNIT: The nucleosome is an octamer containing two molecules CC each of H2A, H2B, H3 and H4. The octamer wraps approximately 146 CC bp of DNA. CC -!- SUBCELLULAR LOCATION: Nuclear. CC -!- SIMILARITY: Belongs to the histone H2A family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z83736; CAB06031.1; -. DR HSSP; P06897; 1AOI. DR Genew; HGNC:4726; HIST1H2AK. DR MIM; 602791; -. DR GO; GO:0000786; C:nucleosome; NAS. DR GO; GO:0003677; F:DNA binding; NAS. DR GO; GO:0007001; P:chromosome organization and biogenesis (sen...; NAS. DR GO; GO:0006334; P:nucleosome assembly; NAS. DR InterPro; IPR009072; Histone-fold. DR InterPro; IPR007125; Histone_core_D. DR InterPro; IPR002119; Histone_H2A. DR InterPro; IPR007124; Hist_TAF. DR Pfam; PF00125; Histone; 1. DR PRINTS; PR00620; HISTONEH2A. DR ProDom; PD000522; Histone_H2A; 1. DR SMART; SM00414; H2A; 1. DR PROSITE; PS00046; HISTONE_H2A; 1. KW Acetylation; Chromosomal protein; DNA-binding; Multigene family; KW Nuclear protein; Nucleosome core. FT INIT_MET 0 0 By similarity. FT MOD_RES 1 1 N-acetylserine (By similarity). FT MOD_RES 5 5 N6-acetyllysine (By similarity). FT MOD_RES 9 9 N6-acetyllysine (By similarity). FT BINDING 119 119 Ubiquitin (By similarity). SQ SEQUENCE 127 AA; 13805 MW; FAED13FE8230C415 CRC64; SGRGKQGGKA RAKAKTRSSR AGLQFPVGRV HRLLRKGNYA ERVGAGAPVY LAAVLEYLTA EILELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLGKV TIAQGGVLPN IQAVLLPKKT ESHHKTK //