ID   MEIS3_HUMAN             Reviewed;         375 AA.
AC   Q99687; A8K1N5; Q6NT73; Q8TC66; Q9NPW2;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 3.
DT   09-APR-2025, entry version 192.
DE   RecName: Full=Homeobox protein Meis3;
DE   AltName: Full=Meis1-related protein 2;
GN   Name=MEIS3; Synonyms=MRG2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Hippocampus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC   TISSUE=Salivary gland, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 168-375 (ISOFORMS 1/3).
RX   PubMed=9049632; DOI=10.1101/gr.7.2.142;
RA   Steelman S., Moskow J.J., Muzynski K., North C., Druck T., Montgomery J.C.,
RA   Huebner K., Daar I.O., Buchberg A.M.;
RT   "Identification of a conserved family of Meis1-related homeobox genes.";
RL   Genome Res. 7:142-156(1997).
CC   -!- FUNCTION: Transcriptional regulator which directly modulates PDPK1
CC       expression, thus promoting survival of pancreatic beta-cells. Also
CC       regulates expression of NDFIP1, BNIP3, and CCNG1.
CC       {ECO:0000250|UniProtKB:P97368}.
CC   -!- INTERACTION:
CC       Q99687-3; P0C7T5: ATXN1L; NbExp=3; IntAct=EBI-18582591, EBI-8624731;
CC       Q99687-3; Q8IYX3: CCDC116; NbExp=3; IntAct=EBI-18582591, EBI-744311;
CC       Q99687-3; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-18582591, EBI-744099;
CC       Q99687-3; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-18582591, EBI-1752811;
CC       Q99687-3; Q8TC76: FAM110B; NbExp=3; IntAct=EBI-18582591, EBI-2558383;
CC       Q99687-3; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-18582591, EBI-7225287;
CC       Q99687-3; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-18582591, EBI-6658203;
CC       Q99687-3; O14964: HGS; NbExp=3; IntAct=EBI-18582591, EBI-740220;
CC       Q99687-3; Q96HW7-3: INTS4; NbExp=3; IntAct=EBI-18582591, EBI-12240836;
CC       Q99687-3; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-18582591, EBI-726510;
CC       Q99687-3; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-18582591, EBI-11742507;
CC       Q99687-3; O95983-2: MBD3; NbExp=3; IntAct=EBI-18582591, EBI-11978579;
CC       Q99687-3; P48426: PIP4K2A; NbExp=3; IntAct=EBI-18582591, EBI-3924422;
CC       Q99687-3; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-18582591, EBI-1567797;
CC       Q99687-3; Q9UIG4: PSORS1C2; NbExp=3; IntAct=EBI-18582591, EBI-11974061;
CC       Q99687-3; P51687: SUOX; NbExp=3; IntAct=EBI-18582591, EBI-3921347;
CC       Q99687-3; O95988: TCL1B; NbExp=3; IntAct=EBI-18582591, EBI-727338;
CC       Q99687-3; Q08117-2: TLE5; NbExp=3; IntAct=EBI-18582591, EBI-11741437;
CC       Q99687-3; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-18582591, EBI-10241197;
CC       Q99687-3; Q14119: VEZF1; NbExp=3; IntAct=EBI-18582591, EBI-11980193;
CC       Q99687-3; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-18582591, EBI-740727;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P97368}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q99687-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q99687-2; Sequence=VSP_012893;
CC       Name=3;
CC         IsoId=Q99687-3; Sequence=VSP_012892;
CC   -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family. {ECO:0000305}.
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DR   EMBL; AK289950; BAF82639.1; -; mRNA.
DR   EMBL; AL359938; CAB95771.1; -; mRNA.
DR   EMBL; CR749687; CAH18472.1; -; mRNA.
DR   EMBL; CH471126; EAW57482.1; -; Genomic_DNA.
DR   EMBL; BC025404; AAH25404.1; -; mRNA.
DR   EMBL; BC069251; AAH69251.1; -; mRNA.
DR   EMBL; U68385; AAB19195.1; -; mRNA.
DR   CCDS; CCDS33064.1; -. [Q99687-2]
DR   CCDS; CCDS46132.1; -. [Q99687-3]
DR   CCDS; CCDS74406.1; -. [Q99687-1]
DR   RefSeq; NP_001009813.1; NM_001009813.3. [Q99687-3]
DR   RefSeq; NP_001287988.1; NM_001301059.2. [Q99687-1]
DR   RefSeq; NP_064545.1; NM_020160.3. [Q99687-2]
DR   AlphaFoldDB; Q99687; -.
DR   SMR; Q99687; -.
DR   BioGRID; 121245; 26.
DR   IntAct; Q99687; 23.
DR   STRING; 9606.ENSP00000453307; -.
DR   iPTMnet; Q99687; -.
DR   PhosphoSitePlus; Q99687; -.
DR   BioMuta; MEIS3; -.
DR   DMDM; 59803105; -.
DR   jPOST; Q99687; -.
DR   MassIVE; Q99687; -.
DR   PeptideAtlas; Q99687; -.
DR   ProteomicsDB; 78398; -. [Q99687-1]
DR   ProteomicsDB; 78399; -. [Q99687-2]
DR   ProteomicsDB; 78400; -. [Q99687-3]
DR   Pumba; Q99687; -.
DR   Antibodypedia; 31559; 501 antibodies from 25 providers.
DR   DNASU; 56917; -.
DR   Ensembl; ENST00000441740.6; ENSP00000388667.2; ENSG00000105419.18. [Q99687-3]
DR   Ensembl; ENST00000558555.6; ENSP00000454073.1; ENSG00000105419.18. [Q99687-1]
DR   Ensembl; ENST00000559524.5; ENSP00000452854.1; ENSG00000105419.18. [Q99687-2]
DR   Ensembl; ENST00000561293.5; ENSP00000453307.1; ENSG00000105419.18. [Q99687-2]
DR   GeneID; 56917; -.
DR   KEGG; hsa:56917; -.
DR   MANE-Select; ENST00000558555.6; ENSP00000454073.1; NM_001301059.2; NP_001287988.1.
DR   UCSC; uc002pgs.5; human. [Q99687-1]
DR   AGR; HGNC:29537; -.
DR   CTD; 56917; -.
DR   DisGeNET; 56917; -.
DR   GeneCards; MEIS3; -.
DR   HGNC; HGNC:29537; MEIS3.
DR   HPA; ENSG00000105419; Tissue enhanced (brain, endometrium).
DR   MIM; 619443; gene.
DR   neXtProt; NX_Q99687; -.
DR   OpenTargets; ENSG00000105419; -.
DR   PharmGKB; PA30742; -.
DR   VEuPathDB; HostDB:ENSG00000105419; -.
DR   GeneTree; ENSGT00940000161057; -.
DR   HOGENOM; CLU_023139_1_1_1; -.
DR   InParanoid; Q99687; -.
DR   OMA; MEGEWHY; -.
DR   OrthoDB; 10056939at2759; -.
DR   PhylomeDB; Q99687; -.
DR   TreeFam; TF318093; -.
DR   PathwayCommons; Q99687; -.
DR   SignaLink; Q99687; -.
DR   BioGRID-ORCS; 56917; 30 hits in 1169 CRISPR screens.
DR   ChiTaRS; MEIS3; human.
DR   GenomeRNAi; 56917; -.
DR   Pharos; Q99687; Tbio.
DR   PRO; PR:Q99687; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q99687; protein.
DR   Bgee; ENSG00000105419; Expressed in body of uterus and 106 other cell types or tissues.
DR   ExpressionAtlas; Q99687; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0001525; P:angiogenesis; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IBA:GO_Central.
DR   GO; GO:0009880; P:embryonic pattern specification; IBA:GO_Central.
DR   GO; GO:0001654; P:eye development; IBA:GO_Central.
DR   GO; GO:0030097; P:hemopoiesis; IBA:GO_Central.
DR   GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   FunFam; 1.10.10.60:FF:000004; Meis2 homeobox isoform 2c; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR001356; HD.
DR   InterPro; IPR009057; Homeodomain-like_sf.
DR   InterPro; IPR008422; KN_HD.
DR   InterPro; IPR032453; PKNOX/Meis_N.
DR   InterPro; IPR050224; TALE_homeobox.
DR   PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF16493; Meis_PKNOX_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; DNA-binding; Homeobox; Nucleus;
KW   Proteomics identification; Reference proteome.
FT   CHAIN           1..375
FT                   /note="Homeobox protein Meis3"
FT                   /id="PRO_0000049110"
FT   DOMAIN          96..179
FT                   /note="MEIS N-terminal"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        262..324
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          25..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          329..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..46
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..241
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         150..166
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_012892"
FT   VAR_SEQ         286
FT                   /note="S -> SRRSEAPVLPDVCLGLGSPSPGPRWARPWGSDCGRPGRQSDSCWWLQ
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_012893"
FT   CONFLICT        1..4
FT                   /note="MARR -> LASQ (in Ref. 2; CAB95771/CAH18472)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        168..169
FT                   /note="KM -> RP (in Ref. 5)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        202
FT                   /note="M -> I (in Ref. 5)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        238
FT                   /note="D -> V (in Ref. 5)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        260
FT                   /note="R -> P (in Ref. 5)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        351
FT                   /note="Q -> E (in Ref. 5)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        356..360
FT                   /note="VRPPG -> FRAPA (in Ref. 5)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        364..370
FT                   /note="MSLNLEG -> DEFGTRKE (in Ref. 5)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   375 AA;  41115 MW;  7C29818279800786 CRC64;
     MARRYDELPH YPGIVDGPAA LASFPETVPA VPGPYGPHRP PQPLPPGLDS DGLKREKDEI
     YGHPLFPLLA LVFEKCELAT CSPRDGAGAG LGTPPGGDVC SSDSFNEDIA AFAKQVRSER
     PLFSSNPELD NLMIQAIQVL RFHLLELEKV HDLCDNFCHR YITCLKGKMP IDLVIEDRDG
     GCREDFEDYP ASCPSLPDQN NMWIRDHEDS GSVHLGTPGP SSGGLASQSG DNSSDQGDGL
     DTSVASPSSG GEDEDLDQER RRNKKRGIFP KVATNIMRAW LFQHLSHPYP SEEQKKQLAQ
     DTGLTILQVN NWFINARRRI VQPMIDQSNR TGQGAAFSPE GQPIGGYTET QPHVAVRPPG
     SVGMSLNLEG EWHYL
//