ID   NELL2_HUMAN             Reviewed;         816 AA.
AC   Q99435; B7Z2U7; B7Z5Q4; B7Z9J5; B7Z9U3; Q96JS2;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   12-AUG-2020, entry version 177.
DE   RecName: Full=Protein kinase C-binding protein NELL2;
DE   AltName: Full=NEL-like protein 2;
DE   AltName: Full=Nel-related protein 2;
DE   Flags: Precursor;
GN   Name=NELL2; Synonyms=NRP2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=8975702; DOI=10.1006/geno.1996.0628;
RA   Watanabe T.K., Katagiri T., Suzuki M., Shimizu F., Fujiwara T.,
RA   Kanemoto N., Nakamura Y., Hirai Y., Maekawa H., Takahashi E.;
RT   "Cloning and characterization of two novel human cDNAs (NELL1 and NELL2)
RT   encoding proteins with six EGF-like repeats.";
RL   Genomics 38:273-276(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
RC   TISSUE=Brain;
RA   Yoshimoto M., Yazaki M., Takayama K., Matsumoto K.;
RT   "Biological functions of a novel human gene, hucep-12, which is
RT   specifically expressed in the central nervous system.";
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
RC   TISSUE=Amygdala, Brain, and Hippocampus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Duodenum;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   PROTEIN SEQUENCE OF 22-36 (ISOFORM 1).
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally verified
RT   cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Required for neuron survival through the modulation of MAPK
CC       pathways (By similarity). Involved in the regulation of hypothalamic
CC       GNRH secretion and the control of puberty (By similarity).
CC       {ECO:0000250|UniProtKB:Q62918}.
CC   -!- SUBUNIT: Homotrimer. Binds to PKC beta-1 (By similarity).
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q99435; Q5VTD9: GFI1B; NbExp=2; IntAct=EBI-946274, EBI-946212;
CC       Q99435-1; Q96MS0: ROBO3; NbExp=3; IntAct=EBI-16185191, EBI-1220465;
CC       Q99435-2; P49639: HOXA1; NbExp=3; IntAct=EBI-17754404, EBI-740785;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q62918}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q99435-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q99435-2; Sequence=VSP_043801;
CC       Name=3;
CC         IsoId=Q99435-3; Sequence=VSP_043802;
CC       Name=4;
CC         IsoId=Q99435-4; Sequence=VSP_043869;
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DR   EMBL; D83018; BAA11681.1; -; mRNA.
DR   EMBL; D89629; BAB46925.1; -; mRNA.
DR   EMBL; AK295125; BAH11983.1; -; mRNA.
DR   EMBL; AK299277; BAH12990.1; -; mRNA.
DR   EMBL; AK315960; BAH14331.1; -; mRNA.
DR   EMBL; AK316058; BAH14429.1; -; mRNA.
DR   EMBL; AC018923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC025253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471111; EAW57873.1; -; Genomic_DNA.
DR   EMBL; BC020544; AAH20544.1; -; mRNA.
DR   CCDS; CCDS44863.1; -. [Q99435-3]
DR   CCDS; CCDS44864.1; -. [Q99435-4]
DR   CCDS; CCDS53781.1; -. [Q99435-2]
DR   CCDS; CCDS8746.1; -. [Q99435-1]
DR   RefSeq; NP_001138579.1; NM_001145107.1. [Q99435-3]
DR   RefSeq; NP_001138580.1; NM_001145108.1. [Q99435-1]
DR   RefSeq; NP_001138581.1; NM_001145109.1. [Q99435-4]
DR   RefSeq; NP_001138582.1; NM_001145110.1. [Q99435-2]
DR   RefSeq; NP_006150.1; NM_006159.2. [Q99435-1]
DR   RefSeq; XP_005268962.1; XM_005268905.3. [Q99435-1]
DR   RefSeq; XP_011536698.1; XM_011538396.1. [Q99435-1]
DR   PDB; 6POG; X-ray; 2.75 A; B=397-638.
DR   PDBsum; 6POG; -.
DR   SMR; Q99435; -.
DR   BioGRID; 110828; 37.
DR   DIP; DIP-49927N; -.
DR   IntAct; Q99435; 39.
DR   MINT; Q99435; -.
DR   STRING; 9606.ENSP00000416341; -.
DR   GlyGen; Q99435; 7 sites.
DR   iPTMnet; Q99435; -.
DR   PhosphoSitePlus; Q99435; -.
DR   BioMuta; NELL2; -.
DR   DMDM; 2494289; -.
DR   MassIVE; Q99435; -.
DR   PaxDb; Q99435; -.
DR   PeptideAtlas; Q99435; -.
DR   PRIDE; Q99435; -.
DR   ProteomicsDB; 78262; -. [Q99435-1]
DR   ProteomicsDB; 78263; -. [Q99435-2]
DR   ProteomicsDB; 78264; -. [Q99435-3]
DR   ProteomicsDB; 78265; -. [Q99435-4]
DR   Antibodypedia; 25202; 187 antibodies.
DR   DNASU; 4753; -.
DR   Ensembl; ENST00000333837; ENSP00000327988; ENSG00000184613. [Q99435-2]
DR   Ensembl; ENST00000395487; ENSP00000378866; ENSG00000184613. [Q99435-4]
DR   Ensembl; ENST00000429094; ENSP00000390680; ENSG00000184613. [Q99435-1]
DR   Ensembl; ENST00000437801; ENSP00000416341; ENSG00000184613. [Q99435-3]
DR   Ensembl; ENST00000452445; ENSP00000394612; ENSG00000184613. [Q99435-1]
DR   Ensembl; ENST00000549027; ENSP00000447927; ENSG00000184613. [Q99435-4]
DR   GeneID; 4753; -.
DR   KEGG; hsa:4753; -.
DR   UCSC; uc001rof.4; human. [Q99435-1]
DR   CTD; 4753; -.
DR   DisGeNET; 4753; -.
DR   EuPathDB; HostDB:ENSG00000184613.10; -.
DR   GeneCards; NELL2; -.
DR   HGNC; HGNC:7751; NELL2.
DR   HPA; ENSG00000184613; Tissue enhanced (blood, brain, fallopian tube).
DR   MIM; 602320; gene.
DR   neXtProt; NX_Q99435; -.
DR   OpenTargets; ENSG00000184613; -.
DR   PharmGKB; PA31553; -.
DR   eggNOG; KOG1217; Eukaryota.
DR   GeneTree; ENSGT00810000125439; -.
DR   HOGENOM; CLU_006887_0_0_1; -.
DR   InParanoid; Q99435; -.
DR   OMA; NCPESQQ; -.
DR   OrthoDB; 767046at2759; -.
DR   PhylomeDB; Q99435; -.
DR   TreeFam; TF323325; -.
DR   PathwayCommons; Q99435; -.
DR   Reactome; R-HSA-428542; Regulation of commissural axon pathfinding by SLIT and ROBO.
DR   BioGRID-ORCS; 4753; 6 hits in 873 CRISPR screens.
DR   ChiTaRS; NELL2; human.
DR   GeneWiki; NELL2; -.
DR   GenomeRNAi; 4753; -.
DR   Pharos; Q99435; Tbio.
DR   PRO; PR:Q99435; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q99435; protein.
DR   Bgee; ENSG00000184613; Expressed in middle temporal gyrus and 218 other tissues.
DR   ExpressionAtlas; Q99435; baseline and differential.
DR   Genevisible; Q99435; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR   GO; GO:0005080; F:protein kinase C binding; IBA:GO_Central.
DR   GO; GO:0070050; P:neuron cellular homeostasis; ISS:UniProtKB.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR001007; VWF_dom.
DR   Pfam; PF07645; EGF_CA; 4.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   Pfam; PF00093; VWC; 2.
DR   SMART; SM00181; EGF; 6.
DR   SMART; SM00179; EGF_CA; 5.
DR   SMART; SM00282; LamG; 1.
DR   SMART; SM00210; TSPN; 1.
DR   SMART; SM00214; VWC; 3.
DR   SMART; SM00215; VWC_out; 2.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 3.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 4.
DR   PROSITE; PS50026; EGF_3; 6.
DR   PROSITE; PS01187; EGF_CA; 3.
DR   PROSITE; PS01208; VWFC_1; 2.
DR   PROSITE; PS50184; VWFC_2; 3.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Calcium; Direct protein sequencing;
KW   Disulfide bond; EGF-like domain; Glycoprotein; Polymorphism;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..21
FT   CHAIN           22..816
FT                   /note="Protein kinase C-binding protein NELL2"
FT                   /id="PRO_0000007666"
FT   DOMAIN          64..228
FT                   /note="Laminin G-like"
FT   DOMAIN          272..331
FT                   /note="VWFC 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT   DOMAIN          397..439
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          440..481
FT                   /note="EGF-like 2; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          482..522
FT                   /note="EGF-like 3; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          523..553
FT                   /note="EGF-like 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          555..601
FT                   /note="EGF-like 5; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          602..637
FT                   /note="EGF-like 6; calcium-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          638..693
FT                   /note="VWFC 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT   DOMAIN          698..756
FT                   /note="VWFC 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        225
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        293
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        298
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        517
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        615
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        635
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        401..413
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        407..422
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        424..438
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        444..457
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        451..466
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        468..480
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        486..499
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        493..508
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        510..521
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        525..535
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        529..541
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        543..552
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        559..572
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        566..581
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        583..600
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        606..619
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        613..628
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        630..636
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   VAR_SEQ         1..18
FT                   /note="MESRVLLRTFCLIFGLGA -> METGLGAPLFKAWLLIS (in isoform
FT                   4)"
FT                   /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2"
FT                   /id="VSP_043869"
FT   VAR_SEQ         1
FT                   /note="M -> MSIRRLLILILKIGRRWTELIRTM (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_043801"
FT   VAR_SEQ         1
FT                   /note="M -> MGFPPLLKGQASATRSSLASCSWVVFFLSCLSRHAPEIEGGRRWTEL
FT                   IRTM (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_043802"
FT   VARIANT         5
FT                   /note="V -> I (in dbSNP:rs2658973)"
FT                   /id="VAR_048987"
FT   VARIANT         347
FT                   /note="N -> D (in dbSNP:rs17574839)"
FT                   /id="VAR_048988"
FT   VARIANT         631
FT                   /note="P -> L (in dbSNP:rs1050710)"
FT                   /id="VAR_048989"
FT   CONFLICT        353
FT                   /note="S -> P (in Ref. 3; BAH12990)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        454
FT                   /note="N -> D (in Ref. 3; BAH12990)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        489
FT                   /note="N -> D (in Ref. 3; BAH14331)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        636
FT                   /note="C -> S (in Ref. 3; BAH14331)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   816 AA;  91346 MW;  89370B987DC7A324 CRC64;
     MESRVLLRTF CLIFGLGAVW GLGVDPSLQI DVLTELELGE STTGVRQVPG LHNGTKAFLF
     QDTPRSIKAS TATAEQFFQK LRNKHEFTIL VTLKQTHLNS GVILSIHHLD HRYLELESSG
     HRNEVRLHYR SGSHRPHTEV FPYILADDKW HKLSLAISAS HLILHIDCNK IYERVVEKPS
     TDLPLGTTFW LGQRNNAHGY FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK
     IMELQDILAK TSAKLSRAEQ RMNRLDQCYC ERTCTMKGTT YREFESWIDG CKNCTCLNGT
     IQCETLICPN PDCPLKSALA YVDGKCCKEC KSICQFQGRT YFEGERNTVY SSSGVCVLYE
     CKDQTMKLVE SSGCPALDCP ESHQITLSHS CCKVCKGYDF CSERHNCMEN SICRNLNDRA
     VCSCRDGFRA LREDNAYCED IDECAEGRHY CRENTMCVNT PGSFMCICKT GYIRIDDYSC
     TEHDECITNQ HNCDENALCF NTVGGHNCVC KPGYTGNGTT CKAFCKDGCR NGGACIAANV
     CACPQGFTGP SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC
     EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC IHDGKVKHNG QIWVLENDRC
     SVCSCQNGFV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC LHQNGETLYN SGDTWVQNCQ
     QCRCLQGEVD CWPLPCPDVE CEFSILPENE CCPRCVTDPC QADTIRNDIT KTCLDEMNVV
     RFTGSSWIKH GTECTLCQCK NGHICCSVDP QCLQEL
//