ID GAS1_MAGOR Reviewed; 251 AA. AC Q96TN6; DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 14-DEC-2022, entry version 43. DE RecName: Full=Appressoria-specific virulence factor GAS1 {ECO:0000303|PubMed:12215509}; DE Flags: Precursor; GN Name=GAS1 {ECO:0000303|PubMed:12215509}; Synonyms=MAS3 {ECO:0000303|Ref.1}; OS Magnaporthe oryzae (Rice blast fungus) (Pyricularia oryzae). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia. OX NCBI_TaxID=318829; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Choi W., Dean R.A.; RT "Sequence analysis and characterization of genes expressed during RT appressorium formation in rice blast fungus, Magnaporthe grisea."; RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, FUNCTION, DISRUPTION PHENOTYPE, AND RP SUBCELLULAR LOCATION. RC STRAIN=Guyane 11; RX PubMed=12215509; DOI=10.1105/tpc.003426; RA Xue C., Park G., Choi W., Zheng L., Dean R.A., Xu J.R.; RT "Two novel fungal virulence genes specifically expressed in appressoria of RT the rice blast fungus."; RL Plant Cell 14:2107-2119(2002). RN [3] RP FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=23454094; DOI=10.1016/j.gep.2013.02.003; RA Jin Q., Li C., Li Y., Shang J., Li D., Chen B., Dong H.; RT "Complexity of roles and regulation of the PMK1-MAPK pathway in mycelium RT development, conidiation and appressorium formation in Magnaporthe RT oryzae."; RL Gene Expr. Patterns 13:133-141(2013). CC -!- FUNCTION: Appressoria-specific virulence factor required for CC appressorial penetration in host and lesion development. CC {ECO:0000269|PubMed:12215509, ECO:0000269|PubMed:23454094}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12215509}. CC Note=Exclusively located in the cytoplasm of appressoria cells. CC {ECO:0000269|PubMed:12215509}. CC -!- INDUCTION: Expressed specifically during appressorium formation. CC {ECO:0000269|PubMed:12215509}. CC -!- DISRUPTION PHENOTYPE: Does not affect vegetative growth, conidiation, CC or appressoria formation, but redices in appressorial penetration and CC lesion development. {ECO:0000269|PubMed:12215509, CC ECO:0000269|PubMed:23454094}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF363065; AAK52794.1; -; Genomic_DNA. DR EMBL; AF433133; AAL28112.1; -; Genomic_DNA. DR AlphaFoldDB; Q96TN6; -. DR OMA; MQCTGTV; -. DR PHI-base; PHI:256; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR InterPro; IPR021476; Egh16-like. DR PANTHER; PTHR34618; SURFACE PROTEIN MAS1, PUTATIVE-RELATED; 1. DR Pfam; PF11327; Egh16-like; 1. PE 2: Evidence at transcript level; KW Cytoplasm; Signal; Virulence. FT SIGNAL 1..21 FT /evidence="ECO:0000255" FT CHAIN 22..251 FT /note="Appressoria-specific virulence factor GAS1" FT /id="PRO_5007715995" FT REGION 40..76 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 57..76 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 251 AA; 26150 MW; 5239F0CB43F13CBF CRC64; MSLKSLIAAT ILAAPLVAGH GAIIKAVGDA GGEGMGLGVV TSTPRDGTRR DPFQQDSTRF KGQQADTFGE TVGGGQNDVE SMTKAIMAET GSQLPQISPG GSLQMTLHQV NGDGAGPYTC ELNDDASGAQ WQQIRVTTTP PGRNSRNRDG AMTDFPLVAE IPQRQACTGT VAGQTNVCLV RCMNAARAGP FGGVVAAQLA GSQTPQAARR ALAESVKRSE LIVSGLKKRG YNIADLSQEE IDELRRDGEI A //