ID MA7D2_HUMAN Reviewed; 732 AA. AC Q96T17; B7Z2J8; B7Z3S7; B9EGC7; C9JMA4; C9JYW0; Q5EBN1; Q5JPS7; Q6PIC7; AC Q8N792; DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot. DT 18-MAY-2010, sequence version 2. DT 25-MAY-2022, entry version 129. DE RecName: Full=MAP7 domain-containing protein 2; GN Name=MAP7D2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5), AND RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 67-732 (ISOFORM 3). RC TISSUE=Brain, Teratocarcinoma, and Thalamus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., RA Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT RP SER-182. RC TISSUE=Liver, Lymph, and Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a RT refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19608861; DOI=10.1126/science.1175371; RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., RA Olsen J.V., Mann M.; RT "Lysine acetylation targets protein complexes and co-regulates major RT cellular functions."; RL Science 325:834-840(2009). RN [6] RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 (ISOFORM 5), AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22814378; DOI=10.1073/pnas.1210303109; RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.; RT "N-terminal acetylome analyses and functional insights of the N-terminal RT acetyltransferase NatB."; RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012). RN [7] RP VARIANT [LARGE SCALE ANALYSIS] PRO-32. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., RA Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal cancers."; RL Science 314:268-274(2006). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; CC IsoId=Q96T17-1; Sequence=Displayed; CC Name=2; CC IsoId=Q96T17-2; Sequence=VSP_028492; CC Name=3; CC IsoId=Q96T17-3; Sequence=VSP_028490, VSP_028491, VSP_028493; CC Name=4; CC IsoId=Q96T17-4; Sequence=VSP_043337; CC Name=5; CC IsoId=Q96T17-5; Sequence=VSP_044657, VSP_044658; CC -!- SIMILARITY: Belongs to the MAP7 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAC05407.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK027409; BAB55093.1; -; mRNA. DR EMBL; AK098768; BAC05407.1; ALT_INIT; mRNA. DR EMBL; AK294788; BAH11884.1; -; mRNA. DR EMBL; AK296319; BAH12313.1; -; mRNA. DR EMBL; AL732366; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC037165; AAH37165.1; -; mRNA. DR EMBL; BC089400; AAH89400.1; -; mRNA. DR EMBL; BC136379; AAI36380.1; -; mRNA. DR CCDS; CCDS14195.1; -. [Q96T17-1] DR CCDS; CCDS55384.1; -. [Q96T17-5] DR CCDS; CCDS55385.1; -. [Q96T17-4] DR CCDS; CCDS55386.1; -. [Q96T17-2] DR RefSeq; NP_001161937.1; NM_001168465.1. [Q96T17-2] DR RefSeq; NP_001161938.1; NM_001168466.1. [Q96T17-4] DR RefSeq; NP_001161939.1; NM_001168467.1. [Q96T17-5] DR RefSeq; NP_689993.2; NM_152780.3. [Q96T17-1] DR AlphaFoldDB; Q96T17; -. DR BioGRID; 129178; 76. DR IntAct; Q96T17; 33. DR MINT; Q96T17; -. DR STRING; 9606.ENSP00000368964; -. DR iPTMnet; Q96T17; -. DR PhosphoSitePlus; Q96T17; -. DR BioMuta; MAP7D2; -. DR DMDM; 296434580; -. DR EPD; Q96T17; -. DR jPOST; Q96T17; -. DR MassIVE; Q96T17; -. DR MaxQB; Q96T17; -. DR PeptideAtlas; Q96T17; -. DR PRIDE; Q96T17; -. DR ProteomicsDB; 12313; -. DR ProteomicsDB; 78169; -. [Q96T17-1] DR ProteomicsDB; 78170; -. [Q96T17-2] DR ProteomicsDB; 78171; -. [Q96T17-3] DR ProteomicsDB; 78172; -. [Q96T17-4] DR Antibodypedia; 63281; 17 antibodies from 8 providers. DR DNASU; 256714; -. DR Ensembl; ENST00000379643.10; ENSP00000368964.5; ENSG00000184368.16. [Q96T17-2] DR Ensembl; ENST00000379651.7; ENSP00000368972.3; ENSG00000184368.16. DR Ensembl; ENST00000443379.7; ENSP00000388239.3; ENSG00000184368.16. [Q96T17-4] DR Ensembl; ENST00000452324.3; ENSP00000413301.3; ENSG00000184368.16. [Q96T17-5] DR GeneID; 256714; -. DR KEGG; hsa:256714; -. DR MANE-Select; ENST00000379643.10; ENSP00000368964.5; NM_001168465.2; NP_001161937.1. [Q96T17-2] DR UCSC; uc004czr.3; human. [Q96T17-1] DR CTD; 256714; -. DR DisGeNET; 256714; -. DR GeneCards; MAP7D2; -. DR HGNC; HGNC:25899; MAP7D2. DR HPA; ENSG00000184368; Tissue enhanced (brain, epididymis). DR neXtProt; NX_Q96T17; -. DR OpenTargets; ENSG00000184368; -. DR PharmGKB; PA162394971; -. DR VEuPathDB; HostDB:ENSG00000184368; -. DR eggNOG; ENOG502QTSG; Eukaryota. DR GeneTree; ENSGT00950000182941; -. DR HOGENOM; CLU_017315_1_0_1; -. DR InParanoid; Q96T17; -. DR OMA; LNTCQEI; -. DR OrthoDB; 265189at2759; -. DR PhylomeDB; Q96T17; -. DR TreeFam; TF332273; -. DR PathwayCommons; Q96T17; -. DR SignaLink; Q96T17; -. DR BioGRID-ORCS; 256714; 13 hits in 694 CRISPR screens. DR ChiTaRS; MAP7D2; human. DR GenomeRNAi; 256714; -. DR Pharos; Q96T17; Tdark. DR PRO; PR:Q96T17; -. DR Proteomes; UP000005640; Chromosome X. DR RNAct; Q96T17; protein. DR Bgee; ENSG00000184368; Expressed in frontal cortex and 153 other tissues. DR Genevisible; Q96T17; HS. DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central. DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central. DR InterPro; IPR008604; MAP7_fam. DR Pfam; PF05672; MAP7; 1. PE 1: Evidence at protein level; KW Acetylation; Alternative splicing; Coiled coil; Reference proteome. FT CHAIN 1..732 FT /note="MAP7 domain-containing protein 2" FT /id="PRO_0000306809" FT REGION 1..64 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 95..123 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 157..186 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 210..244 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 279..509 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 51..146 FT /evidence="ECO:0000255" FT COMPBIAS 47..64 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 165..186 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 214..239 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 291..305 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 329..344 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 359..375 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 401..509 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 1..44 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_044657" FT VAR_SEQ 161 FT /note="D -> DGESENTPPPPLGLAASTLPPDAGTTAAAAESTN (in isoform FT 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_028490" FT VAR_SEQ 162..206 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_043337" FT VAR_SEQ 198..201 FT /note="RVFH -> QAEG (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_028491" FT VAR_SEQ 198 FT /note="R -> RAHHMHLSPMEAILVSRLLTPTQSSLARSRASVMLSGQANDS (in FT isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_028492" FT VAR_SEQ 199..206 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_044658" FT VAR_SEQ 202..732 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_028493" FT VARIANT 32 FT /note="A -> P (in a breast cancer sample; somatic FT mutation)" FT /evidence="ECO:0000269|PubMed:16959974" FT /id="VAR_035450" FT VARIANT 182 FT /note="N -> S (in dbSNP:rs34519770)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_035313" FT CONFLICT 14 FT /note="P -> L (in Ref. 3; AAH89400)" FT /evidence="ECO:0000305" FT CONFLICT 423 FT /note="L -> V (in Ref. 1; BAB55093)" FT /evidence="ECO:0000305" FT CONFLICT 557 FT /note="S -> P (in Ref. 1; BAB55093)" FT /evidence="ECO:0000305" FT CONFLICT 590 FT /note="N -> S (in Ref. 1; BAH11884)" FT /evidence="ECO:0000305" FT MOD_RES Q96T17-5:1 FT /note="N-acetylmethionine" FT /evidence="ECO:0007744|PubMed:22814378" SQ SEQUENCE 732 AA; 81965 MW; 9F3C004D6942F08E CRC64; MERGGGGSGT GSRPEGTARG TSLPGKIAEP GAVRTSQPNY RPQGMEGFLK SDERQRLAKE RREEREKCLA AREQQILEKQ KRARLQYEKQ MEERWRKLEE QRQREDQKRA AVEEKRKQKL REEEERLEAM MRRSLERTQQ LELKKKYSWG APLAIGPGGH DACDKLSTST MSLPKPTEPP MNKRLSSSTV AISYSPDRVF HVCPRLAPLG PLNPSYKSSP TRNIEKKKAT STSTSGAGDV GKEALSGGEA SLVEKVKRGQ RTATSLPVVN FGSPLRRCEF SGGIPKRPSS PVISKTATKA YPQSPKTTKP PYPGSPVKYR LPALSGQDMP KRKAEKEKSN KEREGTLAQQ AAGPQGEEAL EKHVVDKHAS EKHAAAAGGK AENSAALGKP TAGTTDAGEA AKILAEKRRQ ARLQKEQEEQ ERLEKEEQDR LEREELKRKA EEERLRLEEE ARKQEEERKR QEEEKKKQEG EEKRKAGEEA KRKAEEELLL KEKQEQEKQE KAMIEKQKEA AETKAREVAE QMRLEREQIM LQIEQERLER KKRIDEIMKR TRKSDVSPQV KKEDPKVGVQ PAVCVEKKTK LVVPNKMEIN GLNTCQEVNG VDHAAPETYP QDIFSNGLKP AGGLIHLDAL DGKSNSLDDS TEEVQSMDVS PVSKEELISI PEFSPVSEMI PGVSLDQNGT GNARALQDLL DFTGPPTFPK RSSENLSLDD CNKNLIEGFN SPGQETPLNT FC //