ID MA7D2_HUMAN Reviewed; 732 AA. AC Q96T17; B7Z2J8; B7Z3S7; B9EGC7; C9JMA4; C9JYW0; Q5EBN1; Q5JPS7; AC Q6PIC7; Q8N792; DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot. DT 18-MAY-2010, sequence version 2. DT 13-FEB-2019, entry version 111. DE RecName: Full=MAP7 domain-containing protein 2; GN Name=MAP7D2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5), AND RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 67-732 (ISOFORM 3). RC TISSUE=Brain, Teratocarcinoma, and Thalamus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., RA Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., RA Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S., RA Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., RA Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., RA Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., RA Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., RA Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., RA Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., RA Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., RA Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., RA Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., RA Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., RA Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., RA Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., RA Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., RA Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., RA Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., RA Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., RA Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., RA Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., RA Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., RA Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., RA Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., RA de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., RA Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., RA Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., RA Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., RA Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., RA Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., RA Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., RA Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., RA Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., RA Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., RA Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., RA Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., RA Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., RA Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., RA Williams G., Williams L., Williamson A., Williamson H., Wilming L., RA Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., RA Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., RA Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., RA Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., RA Gibbs R.A., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT RP SER-182. RC TISSUE=Liver, Lymph, and Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19608861; DOI=10.1126/science.1175371; RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., RA Walther T.C., Olsen J.V., Mann M.; RT "Lysine acetylation targets protein complexes and co-regulates major RT cellular functions."; RL Science 325:834-840(2009). RN [6] RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 (ISOFORM 5), AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22814378; DOI=10.1073/pnas.1210303109; RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., RA Aldabe R.; RT "N-terminal acetylome analyses and functional insights of the N- RT terminal acetyltransferase NatB."; RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012). RN [7] RP VARIANT [LARGE SCALE ANALYSIS] PRO-32. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., RA Vogelstein B., Kinzler K.W., Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal RT cancers."; RL Science 314:268-274(2006). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Name=1; CC IsoId=Q96T17-1; Sequence=Displayed; CC Name=2; CC IsoId=Q96T17-2; Sequence=VSP_028492; CC Name=3; CC IsoId=Q96T17-3; Sequence=VSP_028490, VSP_028491, VSP_028493; CC Note=No experimental confirmation available.; CC Name=4; CC IsoId=Q96T17-4; Sequence=VSP_043337; CC Note=No experimental confirmation available.; CC Name=5; CC IsoId=Q96T17-5; Sequence=VSP_044657, VSP_044658; CC Note=No experimental confirmation available. Contains a CC N-acetylmethionine at position 1. {ECO:0000244|PubMed:22814378}; CC -!- SIMILARITY: Belongs to the MAP7 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAC05407.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK027409; BAB55093.1; -; mRNA. DR EMBL; AK098768; BAC05407.1; ALT_INIT; mRNA. DR EMBL; AK294788; BAH11884.1; -; mRNA. DR EMBL; AK296319; BAH12313.1; -; mRNA. DR EMBL; AL732366; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC037165; AAH37165.1; -; mRNA. DR EMBL; BC089400; AAH89400.1; -; mRNA. DR EMBL; BC136379; AAI36380.1; -; mRNA. DR CCDS; CCDS14195.1; -. [Q96T17-1] DR CCDS; CCDS55384.1; -. [Q96T17-5] DR CCDS; CCDS55385.1; -. [Q96T17-4] DR CCDS; CCDS55386.1; -. [Q96T17-2] DR RefSeq; NP_001161937.1; NM_001168465.1. [Q96T17-2] DR RefSeq; NP_001161938.1; NM_001168466.1. [Q96T17-4] DR RefSeq; NP_001161939.1; NM_001168467.1. [Q96T17-5] DR RefSeq; NP_689993.2; NM_152780.3. [Q96T17-1] DR UniGene; Hs.127951; -. DR ProteinModelPortal; Q96T17; -. DR BioGrid; 129178; 30. DR IntAct; Q96T17; 11. DR MINT; Q96T17; -. DR iPTMnet; Q96T17; -. DR PhosphoSitePlus; Q96T17; -. DR BioMuta; MAP7D2; -. DR DMDM; 296434580; -. DR jPOST; Q96T17; -. DR MaxQB; Q96T17; -. DR PeptideAtlas; Q96T17; -. DR PRIDE; Q96T17; -. DR ProteomicsDB; 78169; -. DR ProteomicsDB; 78170; -. [Q96T17-2] DR ProteomicsDB; 78171; -. [Q96T17-3] DR ProteomicsDB; 78172; -. [Q96T17-4] DR Ensembl; ENST00000379643; ENSP00000368964; ENSG00000184368. [Q96T17-2] DR Ensembl; ENST00000379651; ENSP00000368972; ENSG00000184368. [Q96T17-1] DR Ensembl; ENST00000443379; ENSP00000388239; ENSG00000184368. [Q96T17-4] DR Ensembl; ENST00000452324; ENSP00000413301; ENSG00000184368. [Q96T17-5] DR GeneID; 256714; -. DR KEGG; hsa:256714; -. DR UCSC; uc004czr.3; human. [Q96T17-1] DR CTD; 256714; -. DR EuPathDB; HostDB:ENSG00000184368.15; -. DR GeneCards; MAP7D2; -. DR H-InvDB; HIX0016691; -. DR HGNC; HGNC:25899; MAP7D2. DR HPA; HPA051508; -. DR HPA; HPA059537; -. DR neXtProt; NX_Q96T17; -. DR OpenTargets; ENSG00000184368; -. DR PharmGKB; PA162394971; -. DR GeneTree; ENSGT00940000153775; -. DR HOGENOM; HOG000232157; -. DR HOVERGEN; HBG055348; -. DR InParanoid; Q96T17; -. DR OMA; GQENTLN; -. DR OrthoDB; 265189at2759; -. DR PhylomeDB; Q96T17; -. DR TreeFam; TF332273; -. DR ChiTaRS; MAP7D2; human. DR GenomeRNAi; 256714; -. DR PRO; PR:Q96T17; -. DR Proteomes; UP000005640; Chromosome X. DR Bgee; ENSG00000184368; Expressed in 128 organ(s), highest expression level in frontal cortex. DR Genevisible; Q96T17; HS. DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central. DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central. DR InterPro; IPR008604; MAP7_fam. DR PANTHER; PTHR15073; PTHR15073; 1. DR Pfam; PF05672; MAP7; 1. PE 1: Evidence at protein level; KW Acetylation; Alternative splicing; Coiled coil; Complete proteome; KW Polymorphism; Reference proteome. FT CHAIN 1 732 MAP7 domain-containing protein 2. FT /FTId=PRO_0000306809. FT COILED 51 146 {ECO:0000255}. FT VAR_SEQ 1 44 Missing (in isoform 5). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_044657. FT VAR_SEQ 161 161 D -> DGESENTPPPPLGLAASTLPPDAGTTAAAAESTN FT (in isoform 3). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_028490. FT VAR_SEQ 162 206 Missing (in isoform 4). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_043337. FT VAR_SEQ 198 201 RVFH -> QAEG (in isoform 3). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_028491. FT VAR_SEQ 198 198 R -> RAHHMHLSPMEAILVSRLLTPTQSSLARSRASVMLS FT GQANDS (in isoform 2). FT {ECO:0000303|PubMed:15489334}. FT /FTId=VSP_028492. FT VAR_SEQ 199 206 Missing (in isoform 5). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_044658. FT VAR_SEQ 202 732 Missing (in isoform 3). FT {ECO:0000303|PubMed:14702039}. FT /FTId=VSP_028493. FT VARIANT 32 32 A -> P (in a breast cancer sample; FT somatic mutation). FT {ECO:0000269|PubMed:16959974}. FT /FTId=VAR_035450. FT VARIANT 182 182 N -> S (in dbSNP:rs34519770). FT {ECO:0000269|PubMed:15489334}. FT /FTId=VAR_035313. FT CONFLICT 14 14 P -> L (in Ref. 3; AAH89400). FT {ECO:0000305}. FT CONFLICT 423 423 L -> V (in Ref. 1; BAB55093). FT {ECO:0000305}. FT CONFLICT 557 557 S -> P (in Ref. 1; BAB55093). FT {ECO:0000305}. FT CONFLICT 590 590 N -> S (in Ref. 1; BAH11884). FT {ECO:0000305}. SQ SEQUENCE 732 AA; 81965 MW; 9F3C004D6942F08E CRC64; MERGGGGSGT GSRPEGTARG TSLPGKIAEP GAVRTSQPNY RPQGMEGFLK SDERQRLAKE RREEREKCLA AREQQILEKQ KRARLQYEKQ MEERWRKLEE QRQREDQKRA AVEEKRKQKL REEEERLEAM MRRSLERTQQ LELKKKYSWG APLAIGPGGH DACDKLSTST MSLPKPTEPP MNKRLSSSTV AISYSPDRVF HVCPRLAPLG PLNPSYKSSP TRNIEKKKAT STSTSGAGDV GKEALSGGEA SLVEKVKRGQ RTATSLPVVN FGSPLRRCEF SGGIPKRPSS PVISKTATKA YPQSPKTTKP PYPGSPVKYR LPALSGQDMP KRKAEKEKSN KEREGTLAQQ AAGPQGEEAL EKHVVDKHAS EKHAAAAGGK AENSAALGKP TAGTTDAGEA AKILAEKRRQ ARLQKEQEEQ ERLEKEEQDR LEREELKRKA EEERLRLEEE ARKQEEERKR QEEEKKKQEG EEKRKAGEEA KRKAEEELLL KEKQEQEKQE KAMIEKQKEA AETKAREVAE QMRLEREQIM LQIEQERLER KKRIDEIMKR TRKSDVSPQV KKEDPKVGVQ PAVCVEKKTK LVVPNKMEIN GLNTCQEVNG VDHAAPETYP QDIFSNGLKP AGGLIHLDAL DGKSNSLDDS TEEVQSMDVS PVSKEELISI PEFSPVSEMI PGVSLDQNGT GNARALQDLL DFTGPPTFPK RSSENLSLDD CNKNLIEGFN SPGQETPLNT FC //