ID O52B2_HUMAN Reviewed; 323 AA. AC Q96RD2; Q8NGM7; DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot. DT 20-JAN-2009, sequence version 3. DT 27-NOV-2024, entry version 167. DE RecName: Full=Olfactory receptor 52B2; DE AltName: Full=Olfactory receptor OR11-70; GN Name=OR52B2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-287. RX PubMed=12213199; DOI=10.1006/geno.2002.6830; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). RN [5] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [6] RP ERRATUM OF PUBMED:14983052. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR52B2"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB065763; BAC05983.1; -; Genomic_DNA. DR EMBL; CH471064; EAW68744.1; -; Genomic_DNA. DR EMBL; BC136732; AAI36733.1; -; mRNA. DR EMBL; BC136733; AAI36734.1; -; mRNA. DR EMBL; AF399505; AAK94990.1; -; Genomic_DNA. DR EMBL; BK004324; DAA04722.1; -; Genomic_DNA. DR CCDS; CCDS53598.1; -. DR RefSeq; NP_001004052.1; NM_001004052.1. DR AlphaFoldDB; Q96RD2; -. DR SMR; Q96RD2; -. DR BioGRID; 129115; 20. DR IntAct; Q96RD2; 18. DR STRING; 9606.ENSP00000432011; -. DR GlyCosmos; Q96RD2; 1 site, No reported glycans. DR GlyGen; Q96RD2; 1 site. DR iPTMnet; Q96RD2; -. DR PhosphoSitePlus; Q96RD2; -. DR BioMuta; OR52B2; -. DR DMDM; 221222519; -. DR MassIVE; Q96RD2; -. DR PaxDb; 9606-ENSP00000432011; -. DR PeptideAtlas; Q96RD2; -. DR Antibodypedia; 57973; 61 antibodies from 18 providers. DR DNASU; 255725; -. DR Ensembl; ENST00000530810.2; ENSP00000432011.1; ENSG00000255307.2. DR GeneID; 255725; -. DR KEGG; hsa:255725; -. DR MANE-Select; ENST00000530810.2; ENSP00000432011.1; NM_001004052.1; NP_001004052.1. DR UCSC; uc010qzy.3; human. DR AGR; HGNC:15207; -. DR CTD; 255725; -. DR GeneCards; OR52B2; -. DR HGNC; HGNC:15207; OR52B2. DR HPA; ENSG00000255307; Not detected. DR neXtProt; NX_Q96RD2; -. DR PharmGKB; PA32396; -. DR VEuPathDB; HostDB:ENSG00000255307; -. DR eggNOG; ENOG502QV28; Eukaryota. DR GeneTree; ENSGT01090000260043; -. DR HOGENOM; CLU_012526_0_0_1; -. DR InParanoid; Q96RD2; -. DR OMA; CIMTHTN; -. DR OrthoDB; 4578140at2759; -. DR PhylomeDB; Q96RD2; -. DR TreeFam; TF343679; -. DR PathwayCommons; Q96RD2; -. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR BioGRID-ORCS; 255725; 15 hits in 756 CRISPR screens. DR GeneWiki; OR52B2; -. DR GenomeRNAi; 255725; -. DR Pharos; Q96RD2; Tdark. DR PRO; PR:Q96RD2; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; Q96RD2; protein. DR Bgee; ENSG00000255307; Expressed in primordial germ cell in gonad and 1 other cell type or tissue. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR CDD; cd15221; 7tmA_OR52B-like; 1. DR FunFam; 1.20.1070.10:FF:000006; Olfactory receptor; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR InterPro; IPR050402; Olfactory_rcpt. DR PANTHER; PTHR26450:SF151; OLFACTORY RECEPTOR 52B2; 1. DR PANTHER; PTHR26450; OLFACTORY RECEPTOR 56B1-RELATED; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..323 FT /note="Olfactory receptor 52B2" FT /id="PRO_0000150767" FT TOPO_DOM 1..27 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 28..48 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 49..56 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 57..77 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 78..101 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 102..122 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 123..141 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 142..162 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 163..198 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 199..219 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 220..239 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 240..260 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 261..275 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 276..296 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 297..323 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 5 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 99..191 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 105 FT /note="F -> Y (in dbSNP:rs16909422)" FT /id="VAR_054126" SQ SEQUENCE 323 AA; 36185 MW; D7C9A5138AB6AB17 CRC64; MSHTNVTIFH PAVFVLPGIP GLEAYHIWLS IPLCLIYITA VLGNSILIVV IVMERNLHVP MYFFLSMLAV MDILLSTTTV PKALAIFWLQ AHNIAFDACV TQGFFVHMMF VGESAILLAM AFDRFVAICA PLRYTTVLTW PVVGRIALAV ITRSFCIIFP VIFLLKRLPF CLTNIVPHSY CEHIGVARLA CADITVNIWY GFSVPIVMVI LDVILIAVSY SLILRAVFRL PSQDARHKAL STCGSHLCVI LMFYVPSFFT LLTHHFGRNI PQHVHILLAN LYVAVPPMLN PIVYGVKTKQ IREGVAHRFF DIKTWCCTSP LGS //