ID   OR6C1_HUMAN             Reviewed;         312 AA.
AC   Q96RD1; B2RNM0;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 2.
DT   25-MAY-2022, entry version 151.
DE   RecName: Full=Olfactory receptor 6C1;
DE   AltName: Full=OST267;
GN   Name=OR6C1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281, AND VARIANTS TYR-130; ASP-165
RP   AND ILE-246.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- INTERACTION:
CC       Q96RD1; P32243-2: OTX2; NbExp=3; IntAct=EBI-12905112, EBI-9087860;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6C1";
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DR   EMBL; AC122684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471054; EAW96806.1; -; Genomic_DNA.
DR   EMBL; BC136957; AAI36958.1; -; mRNA.
DR   EMBL; BC136965; AAI36966.1; -; mRNA.
DR   EMBL; AF399506; AAK94991.1; -; Genomic_DNA.
DR   CCDS; CCDS31818.1; -.
DR   RefSeq; NP_001005182.1; NM_001005182.1.
DR   AlphaFoldDB; Q96RD1; -.
DR   SMR; Q96RD1; -.
DR   BioGRID; 133512; 1.
DR   IntAct; Q96RD1; 1.
DR   STRING; 9606.ENSP00000368990; -.
DR   GlyGen; Q96RD1; 1 site.
DR   iPTMnet; Q96RD1; -.
DR   PhosphoSitePlus; Q96RD1; -.
DR   BioMuta; OR6C1; -.
DR   DMDM; 85541046; -.
DR   PaxDb; Q96RD1; -.
DR   PeptideAtlas; Q96RD1; -.
DR   PRIDE; Q96RD1; -.
DR   Antibodypedia; 68584; 26 antibodies from 15 providers.
DR   DNASU; 390321; -.
DR   Ensembl; ENST00000379668.3; ENSP00000368990.2; ENSG00000205330.4.
DR   Ensembl; ENST00000642104.1; ENSP00000492978.1; ENSG00000205330.4.
DR   GeneID; 390321; -.
DR   KEGG; hsa:390321; -.
DR   MANE-Select; ENST00000642104.1; ENSP00000492978.1; NM_001005182.2; NP_001005182.1.
DR   UCSC; uc010spi.3; human.
DR   CTD; 390321; -.
DR   DisGeNET; 390321; -.
DR   GeneCards; OR6C1; -.
DR   HGNC; HGNC:8355; OR6C1.
DR   HPA; ENSG00000205330; Not detected.
DR   neXtProt; NX_Q96RD1; -.
DR   OpenTargets; ENSG00000205330; -.
DR   PharmGKB; PA32579; -.
DR   VEuPathDB; HostDB:ENSG00000205330; -.
DR   eggNOG; ENOG502SI9E; Eukaryota.
DR   GeneTree; ENSGT01040000240512; -.
DR   HOGENOM; CLU_012526_1_1_1; -.
DR   InParanoid; Q96RD1; -.
DR   OMA; ITFNDCI; -.
DR   OrthoDB; 955774at2759; -.
DR   PhylomeDB; Q96RD1; -.
DR   TreeFam; TF336833; -.
DR   PathwayCommons; Q96RD1; -.
DR   BioGRID-ORCS; 390321; 12 hits in 669 CRISPR screens.
DR   GeneWiki; OR6C1; -.
DR   GenomeRNAi; 390321; -.
DR   Pharos; Q96RD1; Tdark.
DR   PRO; PR:Q96RD1; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q96RD1; protein.
DR   Bgee; ENSG00000205330; Expressed in monocyte and 1 other tissue.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 6C1"
FT                   /id="PRO_0000150623"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..215
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..269
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         130
FT                   /note="C -> Y (in dbSNP:rs7132431)"
FT                   /evidence="ECO:0000269|PubMed:12213199"
FT                   /id="VAR_034239"
FT   VARIANT         165
FT                   /note="H -> D (in dbSNP:rs7132347)"
FT                   /evidence="ECO:0000269|PubMed:12213199"
FT                   /id="VAR_034240"
FT   VARIANT         222
FT                   /note="T -> I (in dbSNP:rs7132600)"
FT                   /id="VAR_034241"
FT   VARIANT         246
FT                   /note="V -> I (in dbSNP:rs7132916)"
FT                   /evidence="ECO:0000269|PubMed:12213199"
FT                   /id="VAR_034242"
SQ   SEQUENCE   312 AA;  35660 MW;  350BD3CD9A91B60E CRC64;
     MRNHTEITEF ILLGLTDDPN FQVVIFVFLL ITYMLSITGN LTLITITLLD SHLQTPMYFF
     LRNFSILEIS FTTVSIPKFL GNIISGDKTI SFNNCIVQLF FFILLGVTEF YLLAAMSYDR
     YVAICKPLHC LSIMNRRVCT LLVFTSWLVS FLIIFPALML LLKLHYCRSN IIDHFTCDYF
     PLLQLACSDT KFLEVMGFSC AAFTLMFTLA LIFLSYIYII RTILRIPSTS QRTKAFSTCS
     SHMVVVSISY GSCIFMYIKP SAKDRVSLSK GVAILNTSVA PMMNPFIYSL RNQQVKQAFI
     NMARKTVFFT ST
//