ID OR4CC_HUMAN Reviewed; 309 AA. AC Q96R67; B2RNF0; Q6IF49; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 10-OCT-2003, sequence version 2. DT 30-NOV-2010, entry version 73. DE RecName: Full=Olfactory receptor 4C12; DE AltName: Full=Olfactory receptor OR11-259; GN Name=OR4C12; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-283. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-278. RX MEDLINE=22202146; PubMed=12213199; DOI=10.1006/geno.2002.6830; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). RN [3] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [4] RP ERRATUM. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). CC -!- FUNCTION: Odorant receptor (Potential). CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium CC (HORDE); CC URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR4C12"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC136850; AAI36851.1; -; mRNA. DR EMBL; BC136851; AAI36852.1; -; mRNA. DR EMBL; AF399576; AAK95061.1; -; Genomic_DNA. DR EMBL; BK004413; DAA04811.1; -; Genomic_DNA. DR IPI; IPI00913994; -. DR RefSeq; NP_001005270.1; NM_001005270.2. DR UniGene; Hs.553669; -. DR ProteinModelPortal; Q96R67; -. DR IntAct; Q96R67; 1. DR STRING; Q96R67; -. DR PRIDE; Q96R67; -. DR Ensembl; ENST00000335238; ENSP00000334418; ENSG00000221954. DR GeneID; 283093; -. DR KEGG; hsa:283093; -. DR UCSC; uc001nhc.1; human. DR CTD; 283093; -. DR GeneCards; GC11M049959; -. DR H-InvDB; HIX0036635; -. DR HGNC; HGNC:15168; OR4C12. DR PharmGKB; PA32254; -. DR eggNOG; prNOG18659; -. DR HOGENOM; HBG755317; -. DR HOVERGEN; HBG017625; -. DR InParanoid; Q96R67; -. DR OMA; WRKKVTS; -. DR OrthoDB; EOG993631; -. DR Reactome; REACT_14797; Signaling by GPCR. DR NextBio; 93610; -. DR CleanEx; HS_OR4C12; -. DR Genevestigator; Q96R67; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro. DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW. DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW. DR InterPro; IPR000276; 7TM_GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_supfam. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR11398; Olfact_rcpt; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Complete proteome; Disulfide bond; KW G-protein coupled receptor; Glycoprotein; Membrane; Olfaction; KW Polymorphism; Receptor; Sensory transduction; Transducer; KW Transmembrane; Transmembrane helix. FT CHAIN 1 309 Olfactory receptor 4C12. FT /FTId=PRO_0000150533. FT TOPO_DOM 1 23 Extracellular (Potential). FT TRANSMEM 24 47 Helical; Name=1; (Potential). FT TOPO_DOM 48 55 Cytoplasmic (Potential). FT TRANSMEM 56 77 Helical; Name=2; (Potential). FT TOPO_DOM 78 98 Extracellular (Potential). FT TRANSMEM 99 118 Helical; Name=3; (Potential). FT TOPO_DOM 119 137 Cytoplasmic (Potential). FT TRANSMEM 138 156 Helical; Name=4; (Potential). FT TOPO_DOM 157 193 Extracellular (Potential). FT TRANSMEM 194 217 Helical; Name=5; (Potential). FT TOPO_DOM 218 233 Cytoplasmic (Potential). FT TRANSMEM 234 256 Helical; Name=6; (Potential). FT TOPO_DOM 257 267 Extracellular (Potential). FT TRANSMEM 268 287 Helical; Name=7; (Potential). FT TOPO_DOM 288 309 Cytoplasmic (Potential). FT CARBOHYD 6 6 N-linked (GlcNAc...) (Potential). FT DISULFID 95 187 By similarity. FT VARIANT 283 283 V -> L (in dbSNP:rs4598671). FT /FTId=VAR_034192. SQ SEQUENCE 309 AA; 34491 MW; 3C6AD9FA309457C9 CRC64; MEKKKNVTEF ILIGLTQNPI MEKVTFVVFL VLYMITLSGN LLIVVTITTS QALSSPMYFF LTHLSLIDTV YSSSSAPKLI VDSFQEKKII SFNGCMAQAY AEHIFGATEI ILLTVMACDC YVAICKPLNY TTIMSHSLCI LLVAVAWVGG FLHATIQILF TVWLPFCGPN VIGHFMCDLY PLLKLVCIDT HTLGLFVAVN SGFICLLNFL ILVVSYVIIL RSLKNNSLEG RCKALSTCIS HIIVVVLFFV PCIFVYLRSV TTLPIDKAVA VFYTMVVPML NPVVYTLRNA EVKSAIRKLW RKKVTSDND //