ID OR4CC_HUMAN Reviewed; 309 AA. AC Q96R67; B2RNF0; Q6IF49; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 10-OCT-2003, sequence version 2. DT 02-OCT-2024, entry version 165. DE RecName: Full=Olfactory receptor 4C12; DE AltName: Full=Olfactory receptor OR11-259; GN Name=OR4C12; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-283. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-278. RX PubMed=12213199; DOI=10.1006/geno.2002.6830; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). RN [3] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [4] RP ERRATUM OF PUBMED:14983052. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C12"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC136850; AAI36851.1; -; mRNA. DR EMBL; BC136851; AAI36852.1; -; mRNA. DR EMBL; AF399576; AAK95061.1; -; Genomic_DNA. DR EMBL; BK004413; DAA04811.1; -; Genomic_DNA. DR CCDS; CCDS31496.1; -. DR RefSeq; NP_001005270.3; NM_001005270.4. DR AlphaFoldDB; Q96R67; -. DR SMR; Q96R67; -. DR STRING; 9606.ENSP00000334418; -. DR GlyCosmos; Q96R67; 1 site, No reported glycans. DR GlyGen; Q96R67; 1 site. DR iPTMnet; Q96R67; -. DR PhosphoSitePlus; Q96R67; -. DR BioMuta; OR4C12; -. DR DMDM; 38372848; -. DR PaxDb; 9606-ENSP00000334418; -. DR TopDownProteomics; Q96R67; -. DR Antibodypedia; 58926; 99 antibodies from 20 providers. DR DNASU; 283093; -. DR Ensembl; ENST00000335238.4; ENSP00000334418.4; ENSG00000221954.2. DR Ensembl; ENST00000639310.1; ENSP00000491819.1; ENSG00000284255.1. DR GeneID; 283093; -. DR KEGG; hsa:283093; -. DR MANE-Select; ENST00000335238.4; ENSP00000334418.4; NM_001005270.4; NP_001005270.3. DR UCSC; uc010ria.2; human. DR AGR; HGNC:15168; -. DR CTD; 283093; -. DR DisGeNET; 283093; -. DR GeneCards; OR4C12; -. DR HGNC; HGNC:15168; OR4C12. DR HPA; ENSG00000221954; Not detected. DR neXtProt; NX_Q96R67; -. DR OpenTargets; ENSG00000221954; -. DR PharmGKB; PA32254; -. DR VEuPathDB; HostDB:ENSG00000221954; -. DR eggNOG; ENOG502SHUM; Eukaryota. DR GeneTree; ENSGT00940000162374; -. DR HOGENOM; CLU_012526_5_5_1; -. DR InParanoid; Q96R67; -. DR OMA; AYAEHIF; -. DR OrthoDB; 4052270at2759; -. DR PhylomeDB; Q96R67; -. DR TreeFam; TF337350; -. DR PathwayCommons; Q96R67; -. DR Reactome; R-HSA-381753; Olfactory Signaling Pathway. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR BioGRID-ORCS; 283093; 9 hits in 695 CRISPR screens. DR GeneWiki; OR4C12; -. DR GenomeRNAi; 283093; -. DR Pharos; Q96R67; Tdark. DR PRO; PR:Q96R67; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; Q96R67; protein. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR CDD; cd15939; 7tmA_OR4A-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR InterPro; IPR050427; Olfactory_Receptors. DR PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR48002:SF105; OLFACTORY RECEPTOR 4C12; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..309 FT /note="Olfactory receptor 4C12" FT /id="PRO_0000150533" FT TOPO_DOM 1..23 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 24..47 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 48..55 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 56..77 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 78..98 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 99..118 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 119..137 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 138..156 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 157..193 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 194..217 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 218..233 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 234..256 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 257..267 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 268..287 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 288..309 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 6 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 95..187 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 283 FT /note="V -> L (in dbSNP:rs4598671)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_034192" SQ SEQUENCE 309 AA; 34491 MW; 3C6AD9FA309457C9 CRC64; MEKKKNVTEF ILIGLTQNPI MEKVTFVVFL VLYMITLSGN LLIVVTITTS QALSSPMYFF LTHLSLIDTV YSSSSAPKLI VDSFQEKKII SFNGCMAQAY AEHIFGATEI ILLTVMACDC YVAICKPLNY TTIMSHSLCI LLVAVAWVGG FLHATIQILF TVWLPFCGPN VIGHFMCDLY PLLKLVCIDT HTLGLFVAVN SGFICLLNFL ILVVSYVIIL RSLKNNSLEG RCKALSTCIS HIIVVVLFFV PCIFVYLRSV TTLPIDKAVA VFYTMVVPML NPVVYTLRNA EVKSAIRKLW RKKVTSDND //