ID   OR2V2_HUMAN             Reviewed;         315 AA.
AC   Q96R30; Q6IFL6; Q8NGV1;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 3.
DT   12-OCT-2022, entry version 147.
DE   RecName: Full=Olfactory receptor 2V2;
DE   AltName: Full=Olfactory receptor 2V3;
DE   AltName: Full=Olfactory receptor OR5-3;
GN   Name=OR2V2; Synonyms=OR2V3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ARG-221.
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2V2";
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DR   EMBL; AB065675; BAC05900.1; -; Genomic_DNA.
DR   EMBL; AF399614; AAK95099.1; -; Genomic_DNA.
DR   EMBL; BK004246; DAA04644.1; -; Genomic_DNA.
DR   CCDS; CCDS4461.1; -.
DR   RefSeq; NP_996763.1; NM_206880.1.
DR   AlphaFoldDB; Q96R30; -.
DR   SMR; Q96R30; -.
DR   STRING; 9606.ENSP00000332185; -.
DR   GlyGen; Q96R30; 1 site.
DR   iPTMnet; Q96R30; -.
DR   PhosphoSitePlus; Q96R30; -.
DR   BioMuta; OR2V2; -.
DR   DMDM; 55977873; -.
DR   MassIVE; Q96R30; -.
DR   PaxDb; Q96R30; -.
DR   PeptideAtlas; Q96R30; -.
DR   PRIDE; Q96R30; -.
DR   Antibodypedia; 62268; 69 antibodies from 18 providers.
DR   DNASU; 285659; -.
DR   Ensembl; ENST00000641492.1; ENSP00000493207.1; ENSG00000182613.3.
DR   Ensembl; ENST00000641791.1; ENSP00000493017.1; ENSG00000182613.3.
DR   GeneID; 285659; -.
DR   KEGG; hsa:285659; -.
DR   MANE-Select; ENST00000641492.1; ENSP00000493207.1; NM_206880.2; NP_996763.1.
DR   UCSC; uc011dhj.2; human.
DR   CTD; 285659; -.
DR   DisGeNET; 285659; -.
DR   GeneCards; OR2V2; -.
DR   HGNC; HGNC:15341; OR2V2.
DR   HPA; ENSG00000182613; Not detected.
DR   neXtProt; NX_Q96R30; -.
DR   OpenTargets; ENSG00000182613; -.
DR   PharmGKB; PA32212; -.
DR   VEuPathDB; HostDB:ENSG00000182613; -.
DR   eggNOG; ENOG502SHXQ; Eukaryota.
DR   GeneTree; ENSGT01060000248540; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; Q96R30; -.
DR   OMA; METWANQ; -.
DR   OrthoDB; 905402at2759; -.
DR   PhylomeDB; Q96R30; -.
DR   TreeFam; TF337295; -.
DR   PathwayCommons; Q96R30; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 285659; 9 hits in 669 CRISPR screens.
DR   GeneWiki; OR2V2; -.
DR   GenomeRNAi; 285659; -.
DR   Pharos; Q96R30; Tdark.
DR   PRO; PR:Q96R30; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q96R30; protein.
DR   Bgee; ENSG00000182613; Expressed in right uterine tube.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Olfactory receptor 2V2"
FT                   /id="PRO_0000150510"
FT   TOPO_DOM        1..26
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..50
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..58
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..80
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..140
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..159
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..220
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..273
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..293
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..315
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        98..190
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         34
FT                   /note="A -> V (in dbSNP:rs17617270)"
FT                   /id="VAR_053160"
FT   VARIANT         221
FT                   /note="H -> R (in dbSNP:rs2546423)"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="VAR_053161"
SQ   SEQUENCE   315 AA;  35339 MW;  8D84C611F9D48B74 CRC64;
     METWVNQSYT DGFFLLGIFS HSTADLVLFS VVMAVFTVAL CGNVLLIFLI YMDPHLHTPM
     YFFLSQLSLM DLMLVCTNVP KMAANFLSGR KSISFVGCGI QIGLFVCLVG SEGLLLGLMA
     YDRYVAISHP LHYPILMNQR VCLQITGSSW AFGIIDGLIQ MVVVMNFPYC GLRKVNHFFC
     EMLSLLKLAC VDTSLFEKVI FACCVFMLLF PFSIIVASYA HILGTVLQMH SAQAWKKALA
     TCSSHLTAVT LFYGAAMFIY LRPRHYRAPS HDKVASIFYT VLTPMLNPLI YSLRNREVMG
     ALRKGLDRCR IGSQH
//