ID   OR5BC_HUMAN             Reviewed;         314 AA.
AC   Q96R08; B2RNL2; Q6IEV5;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2002, sequence version 2.
DT   24-JUL-2024, entry version 166.
DE   RecName: Full=Olfactory receptor 5B12;
DE   AltName: Full=Olfactory receptor 5B16;
DE   AltName: Full=Olfactory receptor OR11-241;
GN   Name=OR5B12; Synonyms=OR5B12P, OR5B16;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-141.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-141.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5B12";
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DR   EMBL; AB065851; BAC06069.1; -; Genomic_DNA.
DR   EMBL; CH471076; EAW73806.1; -; Genomic_DNA.
DR   EMBL; BC136947; AAI36948.1; -; mRNA.
DR   EMBL; BC136948; AAI36949.1; -; mRNA.
DR   EMBL; AF399637; AAK95122.1; -; Genomic_DNA.
DR   EMBL; BK004507; DAA04905.1; -; Genomic_DNA.
DR   CCDS; CCDS31551.1; -.
DR   RefSeq; NP_001004733.1; NM_001004733.2.
DR   AlphaFoldDB; Q96R08; -.
DR   SMR; Q96R08; -.
DR   STRING; 9606.ENSP00000493263; -.
DR   GlyCosmos; Q96R08; 2 sites, No reported glycans.
DR   GlyGen; Q96R08; 2 sites.
DR   iPTMnet; Q96R08; -.
DR   PhosphoSitePlus; Q96R08; -.
DR   BioMuta; OR5B12; -.
DR   DMDM; 20532192; -.
DR   PaxDb; 9606-ENSP00000306657; -.
DR   Antibodypedia; 58770; 184 antibodies from 21 providers.
DR   DNASU; 390191; -.
DR   Ensembl; ENST00000302572.2; ENSP00000306657.2; ENSG00000172362.4.
DR   Ensembl; ENST00000641921.2; ENSP00000493263.1; ENSG00000172362.4.
DR   GeneID; 390191; -.
DR   KEGG; hsa:390191; -.
DR   MANE-Select; ENST00000641921.2; ENSP00000493263.1; NM_001004733.3; NP_001004733.1.
DR   UCSC; uc010rkh.2; human.
DR   AGR; HGNC:15432; -.
DR   CTD; 390191; -.
DR   DisGeNET; 390191; -.
DR   GeneCards; OR5B12; -.
DR   HGNC; HGNC:15432; OR5B12.
DR   HPA; ENSG00000172362; Not detected.
DR   neXtProt; NX_Q96R08; -.
DR   PharmGKB; PA32481; -.
DR   VEuPathDB; HostDB:ENSG00000172362; -.
DR   eggNOG; ENOG502SHXT; Eukaryota.
DR   GeneTree; ENSGT01110000267149; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q96R08; -.
DR   OMA; MGCYVCG; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q96R08; -.
DR   TreeFam; TF352753; -.
DR   PathwayCommons; Q96R08; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 390191; 8 hits in 736 CRISPR screens.
DR   GeneWiki; OR5B12; -.
DR   GenomeRNAi; 390191; -.
DR   Pharos; Q96R08; Tdark.
DR   PRO; PR:Q96R08; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q96R08; Protein.
DR   Bgee; ENSG00000172362; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 7 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15407; 7tmA_OR5B-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48018:SF51; OLFACTORY RECEPTOR 5B12; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Olfactory receptor 5B12"
FT                   /id="PRO_0000150587"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..269
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        261
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         141
FT                   /note="C -> R (in dbSNP:rs4938895)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT                   /id="VAR_053191"
FT   VARIANT         141
FT                   /note="C -> Y (in dbSNP:rs11229457)"
FT                   /id="VAR_053192"
SQ   SEQUENCE   314 AA;  35182 MW;  93BB84F1CACA68F1 CRC64;
     MENNTEVTEF ILVGLTDDPE LQIPLFIVFL FIYLITLVGN LGMIELILLD SCLHTPMYFF
     LSNLSLVDFG YSSAVTPKVM VGFLTGDKFI LYNACATQFF FFVAFITAES FLLASMAYDR
     YAALCKPLHY TTTMTTNVCA CLAIGSYICG FLNASIHTGN TFRLSFCRSN VVEHFFCDAP
     PLLTLSCSDN YISEMVIFFV VGFNDLFSIL VILISYLFIF ITIMKMRSPE GRQKAFSTCA
     SHLTAVSIFY GTGIFMYLRP NSSHFMGTDK MASVFYAIVI PMLNPLVYSL RNKEVKSAFK
     KTVGKAKASI GFIF
//