ID   INT15_HUMAN             Reviewed;         449 AA.
AC   Q96N11; Q9BQ43;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   13-SEP-2023, entry version 130.
DE   RecName: Full=Integrator complex subunit 15 {ECO:0000312|HGNC:HGNC:21702};
GN   Name=INTS15 {ECO:0000312|HGNC:HGNC:21702}; Synonyms=C7orf26;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION AS PART OF THE INTEGRATOR COMPLEX, FUNCTION, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=33973408; DOI=10.15252/msb.202010016;
RA   Drew K., Wallingford J.B., Marcotte E.M.;
RT   "hu.MAP 2.0: integration of over 15,000 proteomic experiments builds a
RT   global compendium of human multiprotein assemblies.";
RL   Mol. Syst. Biol. 17:e10016-e10016(2021).
CC   -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. {ECO:0000305|PubMed:33973408}.
CC   -!- SUBUNIT: Probable component of the multiprotein Integrator (INT)
CC       complex. {ECO:0000269|PubMed:33973408}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:33973408}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q96N11-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96N11-2; Sequence=VSP_007907, VSP_007908;
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DR   EMBL; AK056149; BAB71104.1; -; mRNA.
DR   EMBL; BC005121; AAH05121.1; -; mRNA.
DR   EMBL; BC001076; AAH01076.1; -; mRNA.
DR   CCDS; CCDS5353.1; -. [Q96N11-1]
DR   CCDS; CCDS78206.1; -. [Q96N11-2]
DR   AlphaFoldDB; Q96N11; -.
DR   BioGRID; 122499; 33.
DR   IntAct; Q96N11; 8.
DR   MINT; Q96N11; -.
DR   STRING; 9606.ENSP00000340220; -.
DR   iPTMnet; Q96N11; -.
DR   PhosphoSitePlus; Q96N11; -.
DR   BioMuta; C7orf26; -.
DR   DMDM; 33301033; -.
DR   EPD; Q96N11; -.
DR   jPOST; Q96N11; -.
DR   MassIVE; Q96N11; -.
DR   MaxQB; Q96N11; -.
DR   PaxDb; Q96N11; -.
DR   PeptideAtlas; Q96N11; -.
DR   ProteomicsDB; 77440; -. [Q96N11-1]
DR   ProteomicsDB; 77441; -. [Q96N11-2]
DR   Antibodypedia; 64371; 40 antibodies from 12 providers.
DR   DNASU; 79034; -.
DR   Ensembl; ENST00000344417.10; ENSP00000340220.5; ENSG00000146576.13. [Q96N11-1]
DR   Ensembl; ENST00000359073.9; ENSP00000351974.5; ENSG00000146576.13. [Q96N11-2]
DR   KEGG; hsa:79034; -.
DR   MANE-Select; ENST00000344417.10; ENSP00000340220.5; NM_024067.4; NP_076972.2.
DR   UCSC; uc003sqo.2; human. [Q96N11-1]
DR   AGR; HGNC:21702; -.
DR   CTD; 79034; -.
DR   GeneCards; INTS15; -.
DR   HGNC; HGNC:21702; INTS15.
DR   HPA; ENSG00000146576; Low tissue specificity.
DR   neXtProt; NX_Q96N11; -.
DR   OpenTargets; ENSG00000146576; -.
DR   VEuPathDB; HostDB:ENSG00000146576; -.
DR   eggNOG; ENOG502QW9D; Eukaryota.
DR   GeneTree; ENSGT00390000011370; -.
DR   HOGENOM; CLU_045490_1_0_1; -.
DR   InParanoid; Q96N11; -.
DR   OMA; DDGDCHQ; -.
DR   OrthoDB; 2915665at2759; -.
DR   PhylomeDB; Q96N11; -.
DR   TreeFam; TF324587; -.
DR   PathwayCommons; Q96N11; -.
DR   SignaLink; Q96N11; -.
DR   BioGRID-ORCS; 79034; 445 hits in 1137 CRISPR screens.
DR   ChiTaRS; C7orf26; human.
DR   GenomeRNAi; 79034; -.
DR   Pharos; Q96N11; Tdark.
DR   PRO; PR:Q96N11; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q96N11; Protein.
DR   Bgee; ENSG00000146576; Expressed in granulocyte and 179 other tissues.
DR   ExpressionAtlas; Q96N11; baseline and differential.
DR   Genevisible; Q96N11; HS.
DR   GO; GO:0032039; C:integrator complex; IDA:UniProtKB.
DR   InterPro; IPR027844; INTS15.
DR   PANTHER; PTHR14540:SF2; SIMILAR TO PROTEIN C7ORF26 HOMOLOG; 1.
DR   PANTHER; PTHR14540; UNCHARACTERIZED; 1.
DR   Pfam; PF14964; DUF4507; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Nucleus; Reference proteome.
FT   CHAIN           1..449
FT                   /note="Integrator complex subunit 15"
FT                   /id="PRO_0000089582"
FT   VAR_SEQ         65..83
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_007907"
FT   VAR_SEQ         215..292
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_007908"
FT   VARIANT         245
FT                   /note="R -> C (in dbSNP:rs35534502)"
FT                   /id="VAR_061593"
SQ   SEQUENCE   449 AA;  50047 MW;  CECD14EB3E97A6BA CRC64;
     MSDIRHSLLR RDALSAAKEV LYHLDIYFSS QLQSAPLPIV DKGPVELLEE FVFQVPKERS
     AQPKRLNSLQ ELQLLEIMCN YFQEQTKDSV RQIIFSSLFS PQGNKADDSR MSLLGKLVSM
     AVAVCRIPVL ECAASWLQRT PVVYCVRLAK ALVDDYCCLV PGSIQTLKQI FSASPRFCCQ
     FITSVTALYD LSSDDLIPPM DLLEMIVTWI FEDPRLILIT FLNTPIAANL PIGFLELTPL
     VGLIRWCVKA PLAYKRKKKP PLSNGHVSNK VTKDPGVGMD RDSHLLYSKL HLSVLQVLMT
     LQLHLTEKNL YGRLGLILFD HMVPLVEEIN RLADELNPLN ASQEIELSLD RLAQALQVAM
     ASGALLCTRD DLRTLCSRLP HNNLLQLVIS GPVQQSPHAA LPPGFYPHIH TPPLGYGAVP
     AHPAAHPALP THPGHTFISG VTFPFRPIR
//