ID Q96MN8_HUMAN Unreviewed; 942 AA. AC Q96MN8; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 27-NOV-2024, entry version 97. DE SubName: Full=cDNA FLJ32105 fis, clone OCBBF2001402, moderately similar to Mus musculus NSD1 protein mRNA {ECO:0000313|EMBL:BAB71247.1}; DE Flags: Fragment; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAB71247.1}; RN [1] {ECO:0000313|EMBL:BAB71247.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain {ECO:0000313|EMBL:BAB71247.1}; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., RA Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., RA Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., RA Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., RA Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., RA Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., RA Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., RA Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., RA Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., RA Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., RA Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., RA Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., RA Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., RA Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., RA Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK056667; BAB71247.1; -; mRNA. DR RefSeq; NP_758859.1; NM_172349.2. DR AlphaFoldDB; Q96MN8; -. DR PeptideAtlas; Q96MN8; -. DR DNASU; 64324; -. DR GeneID; 64324; -. DR CTD; 64324; -. DR DisGeNET; 64324; -. DR PharmGKB; PA31790; -. DR OrthoDB; 950362at2759; -. DR BioGRID-ORCS; 64324; 108 hits in 1183 CRISPR screens. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR InterPro; IPR050777; SET2_Histone-Lys_MeTrsfase. DR PANTHER; PTHR22884:SF312; HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-36 SPECIFIC; 1. DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1. PE 2: Evidence at transcript level; KW Chromosome {ECO:0000256|ARBA:ARBA00022454}; KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603}; KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}; KW Transferase {ECO:0000256|ARBA:ARBA00022603}. FT REGION 135..162 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 520..539 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 584..683 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 715..741 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 760..782 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 891..918 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 522..539 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 584..636 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 724..738 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 942 FT /evidence="ECO:0000313|EMBL:BAB71247.1" SQ SEQUENCE 942 AA; 103771 MW; 43C0991BD30CC527 CRC64; MKVSNRRPYR QYYVEAFGDP SERAWVAGKA IVMFEGRHQF EELPVLRRRG KQKEKGYRHK VPQKILSKWE ASVGLAEQYD VPKGSKNRKC IPGSIKLDSE EDMPFEDCTN DPESEHDLLL NGCLKSLAFD SEHSADEKEK PCAKSRARKS SDNPKRTSVK KGHIQFEAHK DERRGKIPEN LGLNFISGDI SDTQASNELS RIANSLTGSN TAPGSFLFSS CGKNTAKKEF ETSNGDSLLG LPEGALISKC SREKNKPQRS LVCGSKVKLC YIGAGDEEKR SDSISICTTS DDGSSDLDPI EHSSESDNSV LEIPDAFDRT ENMLSMQKNE KIKYSRFAAT NTRVKAKQKP LISNSHTDHL MGCTKSAEPG TETSQVNLSD LKASTLVHKP QSDFTNDALS PKFNLSSSIS SENSLIKGGA ANQALLHSKS KQPKFRSIKC KHKENPVMAE PPVINEECSL KCCSSDTKGS PLASISKSGK VDGLKLLNNM HEKTRDSSDI ETAVVKHVLS ELKELSYRSL GEDVSDSGTS KPSKPLLFSS ASSQNHIPIE PDYKFSTLLM MLKDMHDSKT KEQRLMTAQN LVSYRSPGRG DCSTNSPVGV SKVLVSGGST HNSEKKGDGT QNSANPSPSG GDSALSGELS ASLPGLLSDK RDLPASGKSR SDCVTRRNCG RSKPSSKLRD AFSAQMVKNT VNRKALKTER KRKLNQLPSV TLDAVLQGDR ERGGSLRGGA EDPSKEDPLQ IMGHLTSEDG DHFSDVHFDS KVKQSDPGKI SEKGLSFENG KGPELDSVMN SENDELNGVN QVVPKKRWQR LNQRRTKPRK RMNRFKEKEN SECAFRVLLP SDPVQEGRDE FPEHRTPSAS ILEEPLTEQN HADCLDSAGP RLNVCDKSSA SIGDMEKEPG IPSLTPQAEL PEPAVRSEKK RLRKPSKWLL EYTEEYDQIF AP //