ID HARB1_HUMAN Reviewed; 349 AA. AC Q96MB7; DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 16-DEC-2008, entry version 39. DE RecName: Full=Putative nuclease HARBI1; DE EC=3.1.-.-; DE AltName: Full=Harbinger transposase-derived nuclease; GN Name=HARBI1; Synonyms=C11orf77; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Pancreas; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP FUNCTION, COFACTOR, AND TISSUE SPECIFICITY. RX PubMed=15169610; DOI=10.1089/104454904323090949; RA Kapitonov V.V., Jurka J.; RT "Harbinger transposons and an ancient HARBI1 gene derived from a RT transposase."; RL DNA Cell Biol. 23:311-324(2004). RN [4] RP FUNCTION, INTERACTION WITH NAIF1, AND SUBCELLULAR LOCATION. RX PubMed=18339812; DOI=10.1073/pnas.0707746105; RA Sinzelle L., Kapitonov V.V., Grzela D.P., Jursch T., Jurka J., RA Izsvak Z., Ivics Z.; RT "Transposition of a reconstructed Harbinger element in human cells and RT functional homology with two transposon-derived cellular genes."; RL Proc. Natl. Acad. Sci. U.S.A. 105:4715-4720(2008). CC -!- FUNCTION: Transposase-derived protein that may have nuclease CC activity (Potential). Does not have transposase activity. CC -!- COFACTOR: Divalent metal cations (Potential). CC -!- SUBUNIT: Interacts with NAIF1. CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Interaction with CC NAIF1 promotes translocation to the nucleus. CC -!- TISSUE SPECIFICITY: Detected in brain, eye, nerve tissue, kidney CC and lung. CC -!- SIMILARITY: Belongs to the HARBI1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK057237; BAB71391.1; -; mRNA. DR EMBL; BC036925; AAH36925.1; -; mRNA. DR RefSeq; NP_776172.1; -. DR UniGene; Hs.127403; -. DR PRIDE; Q96MB7; -. DR Ensembl; ENSG00000180423; Homo sapiens. DR GeneID; 283254; -. DR KEGG; hsa:283254; -. DR GeneCards; GC11M046583; -. DR HGNC; HGNC:26522; HARBI1. DR HOVERGEN; Q96MB7; -. DR NextBio; 93767; -. DR ArrayExpress; Q96MB7; -. DR CleanEx; HS_HARBI1; -. DR GermOnline; ENSG00000180423; Homo sapiens. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW. PE 1: Evidence at protein level; KW Cytoplasm; Hydrolase; Metal-binding; Nuclease; Nucleus. FT CHAIN 1 349 Putative nuclease HARBI1. FT /FTId=PRO_0000263614. FT METAL 149 149 Divalent metal cation (Potential). FT METAL 199 199 Divalent metal cation (Potential). FT METAL 225 225 Divalent metal cation (Potential). FT METAL 261 261 Divalent metal cation (Potential). SQ SEQUENCE 349 AA; 39146 MW; C424FDE6825A69F2 CRC64; MAIPITVLDC DLLLYGRGHR TLDRFKLDDV TDEYLMSMYG FPRQFIYYLV ELLGANLSRP TQRSRAISPE TQVLAALGFY TSGSFQTRMG DAIGISQASM SRCVANVTEA LVERASQFIR FPADEASIQA LKDEFYGLAG MPGVMGVVDC IHVAIKAPNA EDLSYVNRKG LHSLNCLMVC DIRGTLMTVE TNWPGSLQDC AVLQQSSLSS QFEAGMHKDS WLLGDSSFFL RTWLMTPLHI PETPAEYRYN MAHSATHSVI EKTFRTLCSR FRCLDGSKGA LQYSPEKSSH IILACCVLHN ISLEHGMDVW SSPMTGPMEQ PPEEEYEHME SLDLEADRIR QELMLTHFS //