ID   S45A3_HUMAN             Reviewed;         553 AA.
AC   Q96JT2;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   10-JUL-2007, entry version 29.
DE   Solute carrier family 45 member 3 (Prostate cancer-associated protein
DE   6) (Prostein).
GN   Name=SLC45A3; Synonyms=PCANAP6, PRST;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   TISSUE=Prostate;
RX   MEDLINE=21139094; PubMed=11245466;
RA   Xu J., Kalos M., Stolk J.A., Zasloff E.J., Zhang X., Houghton R.L.,
RA   Filho A.M., Nolasco M., Badaro R., Reed S.G.;
RT   "Identification and characterization of prostein, a novel prostate-
RT   specific protein.";
RL   Cancer Res. 61:1563-1568(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PNS;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=14997204; DOI=10.1038/sj.bjc.6601642;
RA   Kiessling A., Stevanovic S., Fuessel S., Weigle B., Rieger M.A.,
RA   Temme A., Rieber E.P., Schmitz M.;
RT   "Identification of an HLA-A(*)0201-restricted T-cell epitope derived
RT   from the prostate cancer-associated protein prostein.";
RL   Br. J. Cancer 90:1034-1040(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- TISSUE SPECIFICITY: Prostate-specific. Expressed in all prostatic
CC       glandular cells. Expressed both in normal and cancerous prostates.
CC   -!- INDUCTION: Up-regulated by androgens.
CC   -!- MISCELLANEOUS: Marker for prostate cells. May be used, in case of
CC       prostate cancers, as a target antigen for protate carcinomas-
CC       directed cytotoxic T-cell lymphocytes.
CC   -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH)
CC       cation symporter transporter (TC 2.A.2) family.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY033593; AAK54386.1; -; mRNA.
DR   EMBL; BC050416; AAH50416.1; -; mRNA.
DR   UniGene; Hs.278695; -.
DR   Ensembl; ENSG00000158715; Homo sapiens.
DR   KEGG; hsa:85414; -.
DR   HGNC; HGNC:8642; SLC45A3.
DR   MIM; 605097; gene.
DR   PharmGKB; PA32981; -.
DR   ArrayExpress; Q96JT2; -.
DR   GermOnline; ENSG00000158715; Homo sapiens.
DR   RZPD-ProtExp; IOH26726; -.
DR   RZPD-ProtExp; W2845; -.
DR   InterPro; IPR011701; MFS_1.
DR   Pfam; PF07690; MFS_1; 1.
KW   Membrane; Transmembrane; Transport.
FT   CHAIN         1    553       Solute carrier family 45 member 3.
FT                                /FTId=PRO_0000122519.
FT   TRANSMEM     19     39       1 (Potential).
FT   TRANSMEM     52     72       2 (Potential).
FT   TRANSMEM     88    108       3 (Potential).
FT   TRANSMEM    120    140       4 (Potential).
FT   TRANSMEM    161    181       5 (Potential).
FT   TRANSMEM    198    218       6 (Potential).
FT   TRANSMEM    275    295       7 (Potential).
FT   TRANSMEM    323    343       8 (Potential).
FT   TRANSMEM    353    373       9 (Potential).
FT   TRANSMEM    382    402       10 (Potential).
FT   TRANSMEM    522    542       11 (Potential).
FT   COMPBIAS    455    458       Poly-Pro.
SQ   SEQUENCE   553 AA;  59323 MW;  0AFA23FBC742A667 CRC64;
     MVQRLWVSRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE KFMTMVLGIG
     PVLGLVCVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL FLIPRAGWLA GLLCPDPRPL
     ELALLILGVG LLDFCGQVCF TPLEALLSDL FRDPDHCRQA YSVYAFMISL GGCLGYLLPA
     IDWDTSALAP YLGTQEECLF GLLTLIFLTC VAATLLVAEE AALGPTEPAE GLSAPSLSPH
     CCPCRARLAF RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL
     YQGVPRAEPG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG TRAVYLASVA
     AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA SLYHREKQVF LPKYRGDTGG
     ASSEDSLMTS FLPGPKPGAP FPNGHVGAGG SGLLPPPPAL CGASACDVSV RVVVGEPTEA
     RVVPGRGICL DLAILDSAFL LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ
     VVFDKSDLAK YSA
//