ID SC22A_HUMAN Reviewed; 307 AA. AC Q96IW7; B2RE26; Q9Y682; DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 07-OCT-2020, entry version 144. DE RecName: Full=Vesicle-trafficking protein SEC22a; DE AltName: Full=SEC22 vesicle-trafficking protein homolog A; DE AltName: Full=SEC22 vesicle-trafficking protein-like 2; GN Name=SEC22A; Synonyms=SEC22L2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] {ECO:0000312|EMBL:AAD43013.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Umbilical cord blood {ECO:0000312|EMBL:AAD43013.1}; RX PubMed=11042152; DOI=10.1101/gr.140200; RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.; RT "Cloning and functional analysis of cDNAs with open reading frames for 300 RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor RT cells."; RL Genome Res. 10:1546-1560(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Trachea; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000312|EMBL:AAH07122.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Cervix {ECO:0000312|EMBL:AAH07122.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-8, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [6] RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY RP [LARGE SCALE ANALYSIS]. RX PubMed=22814378; DOI=10.1073/pnas.1210303109; RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.; RT "N-terminal acetylome analyses and functional insights of the N-terminal RT acetyltransferase NatB."; RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012). CC -!- FUNCTION: May be involved in vesicle transport between the ER and the CC Golgi complex. {ECO:0000250|UniProtKB:Q642F4}. CC -!- INTERACTION: CC Q96IW7; Q86Y34: ADGRG3; NbExp=3; IntAct=EBI-8652744, EBI-17979264; CC Q96IW7; Q13520: AQP6; NbExp=3; IntAct=EBI-8652744, EBI-13059134; CC Q96IW7; P07307-3: ASGR2; NbExp=3; IntAct=EBI-8652744, EBI-12808270; CC Q96IW7; O75787: ATP6AP2; NbExp=3; IntAct=EBI-8652744, EBI-2512037; CC Q96IW7; Q13323: BIK; NbExp=3; IntAct=EBI-8652744, EBI-700794; CC Q96IW7; Q12983: BNIP3; NbExp=3; IntAct=EBI-8652744, EBI-749464; CC Q96IW7; Q8IYJ2-2: C10orf67; NbExp=3; IntAct=EBI-8652744, EBI-13381098; CC Q96IW7; Q6UWD8: C16orf54; NbExp=3; IntAct=EBI-8652744, EBI-18041102; CC Q96IW7; Q96LL3: C16orf92; NbExp=3; IntAct=EBI-8652744, EBI-12887376; CC Q96IW7; Q9BXU9: CALN1; NbExp=3; IntAct=EBI-8652744, EBI-12187137; CC Q96IW7; Q9UJ71: CD207; NbExp=3; IntAct=EBI-8652744, EBI-2873235; CC Q96IW7; Q9UGN4: CD300A; NbExp=3; IntAct=EBI-8652744, EBI-10320732; CC Q96IW7; P09564: CD7; NbExp=3; IntAct=EBI-8652744, EBI-2836587; CC Q96IW7; P04233-2: CD74; NbExp=3; IntAct=EBI-8652744, EBI-12222807; CC Q96IW7; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-8652744, EBI-1045797; CC Q96IW7; Q8IUN9: CLEC10A; NbExp=3; IntAct=EBI-8652744, EBI-2873246; CC Q96IW7; Q2HXU8-2: CLEC12B; NbExp=3; IntAct=EBI-8652744, EBI-12811991; CC Q96IW7; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-8652744, EBI-11749983; CC Q96IW7; Q9BXN2-6: CLEC7A; NbExp=3; IntAct=EBI-8652744, EBI-11989440; CC Q96IW7; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-8652744, EBI-6942903; CC Q96IW7; P49447: CYB561; NbExp=3; IntAct=EBI-8652744, EBI-8646596; CC Q96IW7; Q53TN4: CYBRD1; NbExp=3; IntAct=EBI-8652744, EBI-8637742; CC Q96IW7; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-8652744, EBI-742054; CC Q96IW7; Q9NR28: DIABLO; NbExp=3; IntAct=EBI-8652744, EBI-517508; CC Q96IW7; Q86UW9: DTX2; NbExp=10; IntAct=EBI-8652744, EBI-740376; CC Q96IW7; Q92838: EDA; NbExp=7; IntAct=EBI-8652744, EBI-529425; CC Q96IW7; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-8652744, EBI-18535450; CC Q96IW7; O75477: ERLIN1; NbExp=6; IntAct=EBI-8652744, EBI-359299; CC Q96IW7; P60508: ERVFRD-1; NbExp=3; IntAct=EBI-8652744, EBI-17973325; CC Q96IW7; Q8TBP5: FAM174A; NbExp=3; IntAct=EBI-8652744, EBI-18636064; CC Q96IW7; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-8652744, EBI-18304435; CC Q96IW7; Q969F0: FATE1; NbExp=6; IntAct=EBI-8652744, EBI-743099; CC Q96IW7; P21217: FUT3; NbExp=3; IntAct=EBI-8652744, EBI-12839380; CC Q96IW7; Q05329: GAD2; NbExp=3; IntAct=EBI-8652744, EBI-9304251; CC Q96IW7; Q6P531: GGT6; NbExp=3; IntAct=EBI-8652744, EBI-2868927; CC Q96IW7; O95377: GJB5; NbExp=3; IntAct=EBI-8652744, EBI-3909454; CC Q96IW7; O95452: GJB6; NbExp=3; IntAct=EBI-8652744, EBI-13345609; CC Q96IW7; O60883: GPR37L1; NbExp=3; IntAct=EBI-8652744, EBI-2927498; CC Q96IW7; Q96HH9: GRAMD2B; NbExp=3; IntAct=EBI-8652744, EBI-2832937; CC Q96IW7; Q8TDQ0: HAVCR2; NbExp=3; IntAct=EBI-8652744, EBI-11472922; CC Q96IW7; Q9UBK5: HCST; NbExp=3; IntAct=EBI-8652744, EBI-2801937; CC Q96IW7; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-8652744, EBI-1052304; CC Q96IW7; P32942: ICAM3; NbExp=3; IntAct=EBI-8652744, EBI-725421; CC Q96IW7; P63252: KCNJ2; NbExp=3; IntAct=EBI-8652744, EBI-703457; CC Q96IW7; Q5T700: LDLRAD1; NbExp=3; IntAct=EBI-8652744, EBI-10173166; CC Q96IW7; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-8652744, EBI-2820517; CC Q96IW7; P43657: LPAR6; NbExp=3; IntAct=EBI-8652744, EBI-2876949; CC Q96IW7; Q8N386: LRRC25; NbExp=3; IntAct=EBI-8652744, EBI-11304917; CC Q96IW7; Q8N112: LSMEM2; NbExp=3; IntAct=EBI-8652744, EBI-10264855; CC Q96IW7; Q9GZU1: MCOLN1; NbExp=3; IntAct=EBI-8652744, EBI-721209; CC Q96IW7; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-8652744, EBI-11956541; CC Q96IW7; Q99735: MGST2; NbExp=3; IntAct=EBI-8652744, EBI-11324706; CC Q96IW7; Q9UPX6: MINAR1; NbExp=3; IntAct=EBI-8652744, EBI-11977115; CC Q96IW7; Q96JA4: MS4A14; NbExp=3; IntAct=EBI-8652744, EBI-12839612; CC Q96IW7; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-8652744, EBI-12806656; CC Q96IW7; Q96JQ5: MS4A4A; NbExp=5; IntAct=EBI-8652744, EBI-12820341; CC Q96IW7; P21757: MSR1; NbExp=7; IntAct=EBI-8652744, EBI-1776976; CC Q96IW7; P35372-10: OPRM1; NbExp=3; IntAct=EBI-8652744, EBI-12807478; CC Q96IW7; Q9H813: PACC1; NbExp=3; IntAct=EBI-8652744, EBI-4319734; CC Q96IW7; O00623: PEX12; NbExp=3; IntAct=EBI-8652744, EBI-594836; CC Q96IW7; P35232: PHB; NbExp=3; IntAct=EBI-8652744, EBI-354213; CC Q96IW7; O14684: PTGES; NbExp=3; IntAct=EBI-8652744, EBI-11161398; CC Q96IW7; Q8TDF6-2: RASGRP4; NbExp=3; IntAct=EBI-8652744, EBI-12816371; CC Q96IW7; Q86VR2: RETREG3; NbExp=5; IntAct=EBI-8652744, EBI-10192441; CC Q96IW7; Q5EBL4-3: RILPL1; NbExp=3; IntAct=EBI-8652744, EBI-12072024; CC Q96IW7; Q6P5S7: RNASEK; NbExp=3; IntAct=EBI-8652744, EBI-18397230; CC Q96IW7; P50876: RNF144A; NbExp=3; IntAct=EBI-8652744, EBI-2340657; CC Q96IW7; Q6ZMZ0: RNF19B; NbExp=3; IntAct=EBI-8652744, EBI-2466594; CC Q96IW7; Q99942: RNF5; NbExp=3; IntAct=EBI-8652744, EBI-348482; CC Q96IW7; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-8652744, EBI-3920694; CC Q96IW7; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-8652744, EBI-17247926; CC Q96IW7; Q9NX18: SDHAF2; NbExp=3; IntAct=EBI-8652744, EBI-713250; CC Q96IW7; P11686: SFTPC; NbExp=6; IntAct=EBI-8652744, EBI-10197617; CC Q96IW7; Q15849: SLC14A2; NbExp=3; IntAct=EBI-8652744, EBI-1573290; CC Q96IW7; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-8652744, EBI-8644112; CC Q96IW7; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-8652744, EBI-17295964; CC Q96IW7; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-8652744, EBI-12898013; CC Q96IW7; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-8652744, EBI-741850; CC Q96IW7; Q9NPE6: SPAG4; NbExp=3; IntAct=EBI-8652744, EBI-10819434; CC Q96IW7; Q9H169-2: STMN4; NbExp=3; IntAct=EBI-8652744, EBI-20117546; CC Q96IW7; Q8TAV4: STOML3; NbExp=3; IntAct=EBI-8652744, EBI-12900395; CC Q96IW7; Q16623: STX1A; NbExp=3; IntAct=EBI-8652744, EBI-712466; CC Q96IW7; P32856-2: STX2; NbExp=3; IntAct=EBI-8652744, EBI-11956649; CC Q96IW7; Q12846: STX4; NbExp=6; IntAct=EBI-8652744, EBI-744942; CC Q96IW7; Q96L08: SUSD3; NbExp=3; IntAct=EBI-8652744, EBI-18194029; CC Q96IW7; Q8N205: SYNE4; NbExp=3; IntAct=EBI-8652744, EBI-7131783; CC Q96IW7; Q9UP52: TFR2; NbExp=3; IntAct=EBI-8652744, EBI-3934135; CC Q96IW7; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-8652744, EBI-12947623; CC Q96IW7; Q9BVK6: TMED9; NbExp=3; IntAct=EBI-8652744, EBI-1056827; CC Q96IW7; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-8652744, EBI-2821497; CC Q96IW7; Q96B96: TMEM159; NbExp=3; IntAct=EBI-8652744, EBI-7055862; CC Q96IW7; Q8WUU8: TMEM174; NbExp=3; IntAct=EBI-8652744, EBI-10276729; CC Q96IW7; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-8652744, EBI-10982110; CC Q96IW7; Q96B21: TMEM45B; NbExp=3; IntAct=EBI-8652744, EBI-3923061; CC Q96IW7; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-8652744, EBI-18178701; CC Q96IW7; Q6P5X7-2: TMEM71; NbExp=3; IntAct=EBI-8652744, EBI-12886878; CC Q96IW7; Q9BSE2: TMEM79; NbExp=7; IntAct=EBI-8652744, EBI-8649725; CC Q96IW7; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-8652744, EBI-12345267; CC Q96IW7; O43557: TNFSF14; NbExp=3; IntAct=EBI-8652744, EBI-524131; CC Q96IW7; Q96A56: TP53INP1; NbExp=3; IntAct=EBI-8652744, EBI-9986117; CC Q96IW7; Q6PIZ9: TRAT1; NbExp=3; IntAct=EBI-8652744, EBI-17710254; CC Q96IW7; Q8IWR1: TRIM59; NbExp=5; IntAct=EBI-8652744, EBI-10262539; CC Q96IW7; P17643: TYRP1; NbExp=3; IntAct=EBI-8652744, EBI-7900408; CC Q96IW7; Q5T4F4: ZFYVE27; NbExp=3; IntAct=EBI-8652744, EBI-3892947; CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; CC Multi-pass membrane protein {ECO:0000250}. CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAD43013.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF100749; AAD43013.1; ALT_FRAME; mRNA. DR EMBL; AK315771; BAG38123.1; -; mRNA. DR EMBL; CH471052; EAW79451.1; -; Genomic_DNA. DR EMBL; BC007122; AAH07122.1; -; mRNA. DR CCDS; CCDS3021.1; -. DR RefSeq; NP_036562.2; NM_012430.4. DR RefSeq; XP_011510975.1; XM_011512673.2. DR RefSeq; XP_011510977.1; XM_011512675.2. DR RefSeq; XP_011510978.1; XM_011512676.2. DR SMR; Q96IW7; -. DR BioGRID; 117937; 117. DR IntAct; Q96IW7; 104. DR MINT; Q96IW7; -. DR STRING; 9606.ENSP00000310521; -. DR iPTMnet; Q96IW7; -. DR PhosphoSitePlus; Q96IW7; -. DR SwissPalm; Q96IW7; -. DR BioMuta; SEC22A; -. DR DMDM; 74732111; -. DR EPD; Q96IW7; -. DR jPOST; Q96IW7; -. DR MassIVE; Q96IW7; -. DR MaxQB; Q96IW7; -. DR PaxDb; Q96IW7; -. DR PeptideAtlas; Q96IW7; -. DR PRIDE; Q96IW7; -. DR ProteomicsDB; 76864; -. DR Antibodypedia; 32946; 31 antibodies. DR DNASU; 26984; -. DR Ensembl; ENST00000309934; ENSP00000310521; ENSG00000121542. DR Ensembl; ENST00000492595; ENSP00000417972; ENSG00000121542. DR GeneID; 26984; -. DR KEGG; hsa:26984; -. DR UCSC; uc003ege.4; human. DR CTD; 26984; -. DR DisGeNET; 26984; -. DR EuPathDB; HostDB:ENSG00000121542.11; -. DR GeneCards; SEC22A; -. DR HGNC; HGNC:20260; SEC22A. DR HPA; ENSG00000121542; Low tissue specificity. DR MIM; 612442; gene. DR neXtProt; NX_Q96IW7; -. DR OpenTargets; ENSG00000121542; -. DR PharmGKB; PA134921956; -. DR eggNOG; KOG0862; Eukaryota. DR GeneTree; ENSGT00940000158470; -. DR InParanoid; Q96IW7; -. DR KO; K08520; -. DR OMA; QCYLFVY; -. DR OrthoDB; 903466at2759; -. DR PhylomeDB; Q96IW7; -. DR TreeFam; TF105933; -. DR PathwayCommons; Q96IW7; -. DR Reactome; R-HSA-204005; COPII-mediated vesicle transport. DR BioGRID-ORCS; 26984; 9 hits in 877 CRISPR screens. DR ChiTaRS; SEC22A; human. DR GeneWiki; SEC22A; -. DR GenomeRNAi; 26984; -. DR Pharos; Q96IW7; Tdark. DR PRO; PR:Q96IW7; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; Q96IW7; protein. DR Bgee; ENSG00000121542; Expressed in calcaneal tendon and 210 other tissues. DR ExpressionAtlas; Q96IW7; baseline and differential. DR Genevisible; Q96IW7; HS. DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:ProtInc. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005215; F:transporter activity; TAS:ProtInc. DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; TAS:ProtInc. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW. DR InterPro; IPR011012; Longin-like_dom_sf. DR InterPro; IPR010908; Longin_dom. DR InterPro; IPR027152; Sec22a. DR InterPro; IPR043546; Sec22a/c. DR PANTHER; PTHR46258; PTHR46258; 1. DR PANTHER; PTHR46258:SF3; PTHR46258:SF3; 1. DR Pfam; PF13774; Longin; 1. DR SMART; SM01270; Longin; 1. DR SUPFAM; SSF64356; SSF64356; 1. DR PROSITE; PS50859; LONGIN; 1. PE 1: Evidence at protein level; KW Acetylation; Coiled coil; Endoplasmic reticulum; ER-Golgi transport; KW Membrane; Phosphoprotein; Protein transport; Reference proteome; KW Transmembrane; Transmembrane helix; Transport. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0000244|PubMed:22814378" FT CHAIN 2..307 FT /note="Vesicle-trafficking protein SEC22a" FT /id="PRO_0000253043" FT TOPO_DOM 2..187 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 188..208 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 209..226 FT /note="Lumenal" FT /evidence="ECO:0000255" FT TRANSMEM 227..247 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 248..253 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 254..271 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 272..274 FT /note="Lumenal" FT /evidence="ECO:0000255" FT TRANSMEM 275..295 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 296..307 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT DOMAIN 8..119 FT /note="Longin" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231" FT MOD_RES 2 FT /note="N-acetylserine" FT /evidence="ECO:0000244|PubMed:22814378" FT MOD_RES 6 FT /note="Phosphoserine" FT /evidence="ECO:0000244|PubMed:18669648" FT MOD_RES 8 FT /note="Phosphoserine" FT /evidence="ECO:0000244|PubMed:18669648" FT CONFLICT 61 FT /note="N -> K (in Ref. 1; AAD43013)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="D -> N (in Ref. 1; AAD43013)" FT /evidence="ECO:0000305" FT CONFLICT 295 FT /note="L -> V (in Ref. 1)" FT /evidence="ECO:0000305" FT CONFLICT 303..304 FT /note="PD -> SR (in Ref. 1)" FT /evidence="ECO:0000305" SQ SEQUENCE 307 AA; 34948 MW; 227A7F6944EC621F CRC64; MSMILSASVI RVRDGLPLSA STDYEQSTGM QECRKYFKML SRKLAQLPDR CTLKTGHYNI NFISSLGVSY MMLCTENYPN VLAFSFLDEL QKEFITTYNM MKTNTAVRPY CFIEFDNFIQ RTKQRYNNPR SLSTKINLSD MQTEIKLRPP YQISMCELGS ANGVTSAFSV DCKGAGKISS AHQRLEPATL SGIVGFILSL LCGALNLIRG FHAIESLLQS DGDDFNYIIA FFLGTAACLY QCYLLVYYTG WRNVKSFLTF GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG KAPDYDV //