ID   ABHD8_HUMAN             Reviewed;         439 AA.
AC   Q96I13; Q9HAE9;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   07-JUL-2009, entry version 52.
DE   RecName: Full=Abhydrolase domain-containing protein 8;
DE            EC=3.-.-.-;
GN   Name=ABHD8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, Lymph, and Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily.
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DR   EMBL; AK021805; BAB13900.1; -; mRNA.
DR   EMBL; BC007895; AAH07895.1; -; mRNA.
DR   EMBL; BC020173; AAH20173.1; -; mRNA.
DR   EMBL; BC039087; AAH39087.1; -; mRNA.
DR   IPI; IPI00101651; -.
DR   RefSeq; NP_078803.4; -.
DR   UniGene; Hs.515664; -.
DR   MEROPS; S33.011; -.
DR   PRIDE; Q96I13; -.
DR   Ensembl; ENSG00000127220; Homo sapiens.
DR   GeneID; 79575; -.
DR   KEGG; hsa:79575; -.
DR   UCSC; uc002ngb.2; human.
DR   GeneCards; GC19M017263; -.
DR   HGNC; HGNC:23759; ABHD8.
DR   PharmGKB; PA134994313; -.
DR   HOVERGEN; Q96I13; -.
DR   OMA; Q96I13; RITSCKG.
DR   NextBio; 68554; -.
DR   ArrayExpress; Q96I13; -.
DR   Bgee; Q96I13; -.
DR   CleanEx; HS_ABHD8; -.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    439       Abhydrolase domain-containing protein 8.
FT                                /FTId=PRO_0000281382.
FT   ACT_SITE    252    252       Charge relay system (By similarity).
FT   ACT_SITE    370    370       Charge relay system (By similarity).
FT   ACT_SITE    398    398       Charge relay system (By similarity).
FT   CONFLICT    103    103       L -> P (in Ref. 1; BAB13900).
SQ   SEQUENCE   439 AA;  47331 MW;  5D6DBB7BDD4A87C3 CRC64;
     MLTGVTDGIF CCLLGTPPNA VGPLESVESS DGYTFVEVKP GRVLRVKHAG PAPAAAPPPP
     SSASSDAAQG DLSGLVRCQR RITVYRNGRL LVENLGRAPR ADLLHGQNGS GEPPAALEVE
     LADPAGSDGR LAPGSAGSGS GSGSGGRRRR ARRPKRTIHI DCEKRITSCK GAQADVVLFF
     IHGVGGSLAI WKEQLDFFVR LGYEVVAPDL AGHGASSAPQ VAAAYTFYAL AEDMRAIFKR
     YAKKRNVLIG HSYGVSFCTF LAHEYPDLVH KVIMINGGGP TALEPSFCSI FNMPTCVLHC
     LSPCLAWSFL KAGFARQGAK EKQLLKEGNA FNVSSFVLRA MMSGQYWPEG DEVYHAELTV
     PVLLVHGMHD KFVPVEEDQR MAEILLLAFL KLIDEGSHMV MLECPETVNT LLHEFLLWEP
     EPSPKALPEP LPAPPEDKK
//