ID   BORC6_HUMAN             Reviewed;         357 AA.
AC   Q96GS4; Q53HS4; Q9NXW8;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   22-APR-2020, entry version 120.
DE   RecName: Full=BLOC-1-related complex subunit 6 {ECO:0000305};
DE   AltName: Full=Lysosome-dispersing protein {ECO:0000303|PubMed:25898167};
DE            Short=Lyspersin {ECO:0000303|PubMed:25898167};
GN   Name=BORCS6 {ECO:0000312|HGNC:HGNC:25939};
GN   Synonyms=C17orf59 {ECO:0000312|HGNC:HGNC:25939};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung, Ovary, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-357.
RC   TISSUE=Adipose tissue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 24-357.
RC   TISSUE=Adipose tissue;
RA   Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA   Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-196 AND SER-199, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; THR-196 AND SER-199, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma, and Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-196, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [9]
RP   FUNCTION, IDENTIFICATION OF THE BORC COMPLEX, AND SUBCELLULAR LOCATION.
RX   PubMed=25898167; DOI=10.1016/j.devcel.2015.02.011;
RA   Pu J., Schindler C., Jia R., Jarnik M., Backlund P., Bonifacino J.S.;
RT   "BORC, a multisubunit complex that regulates lysosome positioning.";
RL   Dev. Cell 33:176-188(2015).
CC   -!- FUNCTION: As part of the BORC complex may play a role in lysosomes
CC       movement and localization at the cell periphery. Associated with the
CC       cytosolic face of lysosomes, the BORC complex may recruit ARL8B and
CC       couple lysosomes to microtubule plus-end-directed kinesin motor.
CC       {ECO:0000269|PubMed:25898167}.
CC   -!- SUBUNIT: Component of the BLOC-one-related complex (BORC) which is
CC       composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and
CC       SNAPIN. {ECO:0000269|PubMed:25898167}.
CC   -!- INTERACTION:
CC       Q96GS4; Q96GS4; NbExp=3; IntAct=EBI-10193358, EBI-10193358;
CC       Q96GS4; Q9NYB9-2: ABI2; NbExp=5; IntAct=EBI-10193358, EBI-11096309;
CC       Q96GS4; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-10193358, EBI-745073;
CC       Q96GS4; Q9UFG5: C19orf25; NbExp=3; IntAct=EBI-10193358, EBI-741214;
CC       Q96GS4; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-10193358, EBI-8643161;
CC       Q96GS4; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-10193358, EBI-747505;
CC       Q96GS4; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-10193358, EBI-10175300;
CC       Q96GS4; Q13561: DCTN2; NbExp=3; IntAct=EBI-10193358, EBI-715074;
CC       Q96GS4; Q9NRI5-2: DISC1; NbExp=4; IntAct=EBI-10193358, EBI-11988027;
CC       Q96GS4; Q12929: EPS8; NbExp=3; IntAct=EBI-10193358, EBI-375576;
CC       Q96GS4; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-10193358, EBI-742102;
CC       Q96GS4; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-10193358, EBI-371876;
CC       Q96GS4; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-10193358, EBI-7225287;
CC       Q96GS4; Q8IZT9: FAM9C; NbExp=3; IntAct=EBI-10193358, EBI-2870039;
CC       Q96GS4; Q9H4M3: FBXO44; NbExp=4; IntAct=EBI-10193358, EBI-2322644;
CC       Q96GS4; Q9H4M3-2: FBXO44; NbExp=8; IntAct=EBI-10193358, EBI-12104696;
CC       Q96GS4; O94868-3: FCHSD2; NbExp=4; IntAct=EBI-10193358, EBI-11958845;
CC       Q96GS4; O95995: GAS8; NbExp=3; IntAct=EBI-10193358, EBI-1052570;
CC       Q96GS4; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-10193358, EBI-2514791;
CC       Q96GS4; O14964: HGS; NbExp=3; IntAct=EBI-10193358, EBI-740220;
CC       Q96GS4; Q2T9L4: INSYN1; NbExp=3; IntAct=EBI-10193358, EBI-4311436;
CC       Q96GS4; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-10193358, EBI-2556193;
CC       Q96GS4; Q9BQD3: KXD1; NbExp=4; IntAct=EBI-10193358, EBI-739657;
CC       Q96GS4; Q9Y2Q5: LAMTOR2; NbExp=4; IntAct=EBI-10193358, EBI-2643704;
CC       Q96GS4; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-10193358, EBI-739832;
CC       Q96GS4; Q13503: MED21; NbExp=3; IntAct=EBI-10193358, EBI-394678;
CC       Q96GS4; P00540: MOS; NbExp=4; IntAct=EBI-10193358, EBI-1757866;
CC       Q96GS4; Q9GZM8: NDEL1; NbExp=3; IntAct=EBI-10193358, EBI-928842;
CC       Q96GS4; P55347: PKNOX1; NbExp=4; IntAct=EBI-10193358, EBI-1373569;
CC       Q96GS4; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-10193358, EBI-1504830;
CC       Q96GS4; Q8N443: RIBC1; NbExp=3; IntAct=EBI-10193358, EBI-10265323;
CC       Q96GS4; Q149N8: SHPRH; NbExp=3; IntAct=EBI-10193358, EBI-714105;
CC       Q96GS4; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-10193358, EBI-742688;
CC       Q96GS4; B2RWP4: TACC2; NbExp=6; IntAct=EBI-10193358, EBI-14211313;
CC       Q96GS4; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-10193358, EBI-739895;
CC       Q96GS4; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-10193358, EBI-2799833;
CC       Q96GS4; Q96HA8: WDYHV1; NbExp=3; IntAct=EBI-10193358, EBI-741158;
CC       Q96GS4; Q8N720: ZNF655; NbExp=3; IntAct=EBI-10193358, EBI-625509;
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000305|PubMed:25898167}.
CC   -!- SIMILARITY: Belongs to the BORCS6 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH09261.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH18880.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH70272.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAA90889.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAD96226.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC129492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC009261; AAH09261.1; ALT_INIT; mRNA.
DR   EMBL; BC018880; AAH18880.1; ALT_INIT; mRNA.
DR   EMBL; BC070272; AAH70272.1; ALT_INIT; mRNA.
DR   EMBL; AK000021; BAA90889.1; ALT_INIT; mRNA.
DR   EMBL; AK222506; BAD96226.1; ALT_INIT; mRNA.
DR   CCDS; CCDS11133.2; -.
DR   RefSeq; NP_060092.2; NM_017622.2.
DR   SMR; Q96GS4; -.
DR   BioGrid; 120149; 60.
DR   ComplexPortal; CPX-5029; BORC complex.
DR   CORUM; Q96GS4; -.
DR   DIP; DIP-29465N; -.
DR   IntAct; Q96GS4; 77.
DR   STRING; 9606.ENSP00000373669; -.
DR   iPTMnet; Q96GS4; -.
DR   MetOSite; Q96GS4; -.
DR   PhosphoSitePlus; Q96GS4; -.
DR   BioMuta; BORCS6; -.
DR   DMDM; 296434462; -.
DR   EPD; Q96GS4; -.
DR   jPOST; Q96GS4; -.
DR   MassIVE; Q96GS4; -.
DR   MaxQB; Q96GS4; -.
DR   PaxDb; Q96GS4; -.
DR   PeptideAtlas; Q96GS4; -.
DR   PRIDE; Q96GS4; -.
DR   ProteomicsDB; 76660; -.
DR   Antibodypedia; 47971; 109 antibodies.
DR   Ensembl; ENST00000389017; ENSP00000373669; ENSG00000196544.
DR   GeneID; 54785; -.
DR   KEGG; hsa:54785; -.
DR   UCSC; uc010vut.3; human.
DR   CTD; 54785; -.
DR   GeneCards; BORCS6; -.
DR   HGNC; HGNC:25939; BORCS6.
DR   HPA; ENSG00000196544; Tissue enhanced (blood).
DR   MIM; 616599; gene.
DR   neXtProt; NX_Q96GS4; -.
DR   OpenTargets; ENSG00000196544; -.
DR   PharmGKB; PA142672242; -.
DR   eggNOG; KOG4514; Eukaryota.
DR   eggNOG; ENOG4111TSS; LUCA.
DR   GeneTree; ENSGT00490000043453; -.
DR   HOGENOM; CLU_782948_0_0_1; -.
DR   InParanoid; Q96GS4; -.
DR   KO; K20820; -.
DR   OMA; RHKDPAP; -.
DR   OrthoDB; 1229804at2759; -.
DR   PhylomeDB; Q96GS4; -.
DR   ChiTaRS; BORCS6; human.
DR   GenomeRNAi; 54785; -.
DR   Pharos; Q96GS4; Tdark.
DR   PRO; PR:Q96GS4; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q96GS4; protein.
DR   Bgee; ENSG00000196544; Expressed in deltoid and 190 other tissues.
DR   Genevisible; Q96GS4; HS.
DR   GO; GO:0099078; C:BORC complex; IDA:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032418; P:lysosome localization; IMP:UniProtKB.
DR   InterPro; IPR019314; BORCS6.
DR   PANTHER; PTHR13440; PTHR13440; 1.
DR   Pfam; PF10157; BORCS6; 1.
PE   1: Evidence at protein level;
KW   Lysosome; Membrane; Phosphoprotein; Reference proteome.
FT   CHAIN           1..357
FT                   /note="BLOC-1-related complex subunit 6"
FT                   /id="PRO_0000286827"
FT   COMPBIAS        231..258
FT                   /note="Pro-rich"
FT   MOD_RES         168
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:23186163"
FT   MOD_RES         196
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000244|PubMed:18669648,
FT                   ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569"
FT   MOD_RES         199
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:18669648,
FT                   ECO:0000244|PubMed:23186163"
FT   CONFLICT        202
FT                   /note="E -> K (in Ref. 3; BAA90889)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        336
FT                   /note="Q -> R (in Ref. 3; BAA90889 and 4; BAD96226)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   357 AA;  37226 MW;  BBA89770528FA9E9 CRC64;
     MESSRGRPGP ETDLLAVAEH QALVFGGGPG RTSSEPPAGL RVSGEEETEN VGGANRHPRT
     SPKTSSCGVV HRPEREALEN EPGPQGTLSG AGSRRGAPGA EHEPSLSSRH KNPAPPEGKP
     SSGRDCRRGG PGGGMDVEQQ EEEDNDEEAA AGSRAGRSFS SRLQDSRSLD GLSEACGGAG
     SSGSAESGAG GGRRATISSP LELEGTVSRH GDLTHFVANN LQLKIRLSGA PPPPPSAPAR
     PCPAPAPTPT PAIPPIDPEV LRDLERLSRE LGGRVDRLLR GLGGAVQELT ALSVGCIQTY
     RDAVDSLGEA VDMSIKGMYT LLARCEELER ALQPVQGLAR QVRDIRRTLE VLEALCK
//